Redox-response microsphere and preparing and degradation methods

Abstract

The invention belongs to the technical field of organosilicone hybrid materials, and discloses a redox-response microsphere and preparing and degradation methods. The preparing method includes the steps that octavinyl-polyhedral oligomeric silsesquioxane, elemental sulfur / alicyclic olefin copolymer and a stabilizer are dissolved in an organic solvent to form an organic phase; a surfactant is dissolved in water to form a water phase; the organic phase and the water phase are mixed and emulsified, and emulsion is obtained; the obtained emulsion is reacted under the stirring and uv-irradiation conditions, a product is dried, and the redox-response microsphere is obtained. The redox-response microsphere and 30% by weight of a H2O2 solution are dispersed in water and stirred, and degradation ofthe redox-response microsphere is completed. According to the redox-response microsphere and the preparing and degradation methods, the microsphere is obtained in a polymerization mode with a photo-initiation miniemulsion mercaptan-alkene clicking method, and the microsphere prepared with the method has the advantages of being even in distribution, free of by-product and free of radical initiator, and is degradable, environmentally friendly and harmless.

Description

technical field [0001] The invention belongs to the field of organosilicon hybrid materials, and in particular relates to a redox responsive microsphere and a preparation and degradation method. Background technique [0002] Due to the high mechanical strength, good chemical stability and adjustable size of silica microspheres, they are often used to prepare some composite materials available in the field of therapeutics and imaging. In a large number of studies, researchers loaded drugs or imaging agents inside or on the surface of porous microspheres, and used the microspheres to deliver drugs or imaging agents to target tissues. Usually, the controllable release of the microspheres to the load can be achieved by means of pH response or light stimulus response. [0003] The commonly used preparation method of microspheres is the soft template method to prepare silicon microspheres. Soft templates include surfactants and amphiphilic block copolymers. Due to the large mol...

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Problems solved by technology

However, due to the limitation of molecular weight in the process of preparing microspheres, the pore size and wall thickness of the obtained materials are relatively small, which limits the application of the obtained microspheres

At the same time, due to the high stability of the silicon microspheres prepared by using template polymers, they will continue to deposit after long-term use, which brings certain difficulties to subsequent processing.

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