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Atomizing preparation method of micro-particle drug and manufacturing device

A technology of ultra-fine particles and preparation device, which is applied in the fields of drug devices, atomizers for treatment, and other medical devices, etc., can solve the problems of inability to process and obtain ultra-fine drug particles in large quantities, affecting drug efficacy, and high cost , to achieve the effect of being suitable for large-scale industrial application, ensuring the drug delivery effect, and reducing the production cost

Active Publication Date: 2018-05-18
SOUTH CHINA AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] However, the existing commonly used aerosols use carbon dioxide as a carrier, which is costly, and the use of carbon dioxide is likely to inhibit respiration, which in turn affects the efficacy of the drug.
Moreover, the existing technology generally adopts supercritical fluid technology to prepare ultrafine particles. When this method cannot carry out long-lasting mass processing and acquisition of ultrafine drug particles, it cannot be industrialized in large quantities.

Method used

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  • Atomizing preparation method of micro-particle drug and manufacturing device
  • Atomizing preparation method of micro-particle drug and manufacturing device
  • Atomizing preparation method of micro-particle drug and manufacturing device

Examples

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preparation example Construction

[0021] The present invention specifically describes the atomization preparation method of ultrafine particle medicine, and the atomization preparation method of ultrafine particle drug comprises the following steps:

[0022] The aerosol carrier is water, and the existing aerosol carrier often uses carbon dioxide, but carbon dioxide has an inhibitory effect on respiration, and the cost of carbon dioxide is relatively high, and using water as an aerosol carrier can reduce production costs on the one hand, and on the other hand Can reduce CO 2 It has a respiratory inhibitory effect on livestock and poultry, and at the same time, uses the respiratory mucosa of livestock and poultry to increase the absorption of drugs and improve the efficacy of the drug.

[0023] First, the mixed solution obtained by mixing the active ingredient with the solvent is the drug. The active ingredient used is a drug with low or extremely low solubility in ethanol, but has water-soluble cephalosporins, ...

no. 1 example

[0034] The invention provides an atomization preparation method of ultrafine particle medicine, comprising the following steps:

[0035] The mixed solution obtained after mixing the active ingredient with the solvent is the drug, wherein the solvent is 70% ethanol aqueous solution, and the concentration of the active ingredient in the drug is 40 mg / mL.

[0036] Distribution The aerosol carrier and the drug are kept warm at a temperature of 30°C.

[0037] The medicine is mixed with the aerosol carrier, and the mixture of the medicine and the aerosol carrier is insulated during mixing, and the temperature of the heat preservation is 30°C. When the drug and the aerosol carrier are mixed, the flow ratio of the aerosol carrier to the drug is 0.7, and the mixing pressure is 10Mpa.

[0038] Then, the first cavitation, the second cavitation and ultrasonic atomization are performed in sequence, and the frequency of ultrasonic atomization is 1.5 MHz. At this time, the moisture content...

no. 2 example

[0040] The method for preparing an atomized medicine with ultrafine particles provided by the present invention is basically the same as the method for preparing an atomized medicine with ultrafine particles provided in the first embodiment, except that the operating conditions are changed.

[0041] The solvent is 65% ethanol aqueous solution, the concentration of the active ingredient in the drug is 70mg / mL, the temperature of the heat preservation is 90°C, the flow ratio of the aerosol carrier and the drug is 1.3, and the mixing pressure is 25Mpa. The frequency of ultrasonic atomization is 3MHz. Then it is dried, and the moisture content in the aerosol is 40%.

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Abstract

The invention relates to the field of drug preparation, in particular to an atomizing preparation method of a micro-particle drug and a manufacturing device. The atomizing preparation method of the micro-particle drug comprises the following steps that medicines and an aerosol carrier are mixed, subjected to cavitation at least two times and then subjected to ultrasonic atomization. Compared withan existing method, the preparation method has the advantages that the operation is simple, large-scale production can be achieved, requirements for instruments are low, through two-time cavitation and atomization, all the medicines can be turned into micro particles with the particle diameter of 1-3 micrometers, and then the drug delivery effect of the drug is ensured.

Description

technical field [0001] The invention relates to the field of medicine preparation, in particular to an atomization preparation method and a manufacturing device of ultrafine particle medicine. Background technique [0002] The aerosol delivery formulation (ADF) is that after the drug is ultrafinely processed into aerosol particles, the surface area is greatly increased, and the surface energy is significantly changed. With the increase of solubility, the adhesion is enhanced, which can be passed Respiration is sent directly into the deep lungs, resulting in higher potency and lower drug usage. Studies have shown that the drug particle size (particle size, PS) should be between 1 and 5 μm, and the particle size distribution (particle size distribution, PSD) has certain requirements. If the particle is smaller than 1 μm, it will be suspended in the bronchi, forming Brownian motion and cannot be directly sent to the lungs; if the particle is larger than 5 μm, it is easy to col...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M11/00A61M31/00
CPCA61M11/003A61M11/005A61M31/00A61M2210/1025A61M2210/005B05B17/0607
Inventor 孙永学王晓俊逸刘雅红王勉之
Owner SOUTH CHINA AGRI UNIV
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