Method for highly selectively extracting solanesol

A high-selectivity, solanesol technology, applied in the field of separation and purification of plant active ingredients, can solve the problems of complicated extraction process, large-scale production difficulty, and low product purity, so as to achieve high product purity and improve comprehensive utilization rate , The effect of simple process

Active Publication Date: 2018-05-18
GUANGDONG BRANCH OF CHINA TOBACCO GENERAL +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Two, the extraction rate of the product is low and the yield is low, and the product purity is not high simultaneously;
[0008] 3. There are many extraction processes and large-scale production is difficult
At present, there is no report on the application of silver ion complex extraction method to extract solanesol from tobacco

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] Collect waste tobacco leaves, remove moldy tobacco leaves and impurities, add tobacco leaves and water according to the weight ratio of tobacco leaves: water = 1:10, soak at 40°C for 2 hours, filter, and wash the filter residue with water several times until the filtrate is colorless. Collect the filter residue, put it in an oven and bake at 80° C. for 4 hours, and pulverize the filter residue to obtain 20-40 mesh tobacco leaf coarse powder.

[0049] Take 10 g of the tobacco leaves obtained above, add 100 ml of ammonia water with a concentration of 15%, seal it and heat it in a water bath at 40° C. for 2 hours, then filter under reduced pressure, discard the filtrate, and keep the filter residue.

[0050] Add 150ml of extraction solvent (volume ratio: 40:60) consisting of 95% methanol and n-hexane to the above filter residue, the ratio of filter residue to extraction solvent (weight: volume) is 1:10, reflux and stir for 3 hours, cool and filter, The filtrate was obtaine...

Embodiment 2

[0055] Collect waste tobacco leaves, remove moldy tobacco leaves and impurities, add tobacco leaves and water according to the weight ratio of tobacco leaves: water = 1:20, soak at 60°C for 2 hours, filter, and wash the filter residue with water several times until the filtrate is colorless. Collect the filter residue, put it in an oven and bake at 60° C. for 4 hours, and pulverize the filter residue to obtain 20-40 mesh tobacco powder.

[0056] Take 10 g of the tobacco leaves obtained above, add 100 ml of ammonia water with a concentration of 10%, place in a water bath at 60°C after sealing, heat for 2 hours, then filter under reduced pressure, discard the filtrate, and keep the filter residue.

[0057] Add 150ml of extraction solvent composed of 95% methanol and n-hexane to the above filter residue, the volume ratio of the two is 50:50, the ratio of filter residue to extraction solvent is 1:20, reflux and stir for 5 hours, cool and filter to obtain the filtrate, repeat Extra...

Embodiment 3

[0062] Collect waste tobacco leaves, remove moldy tobacco leaves and impurities, add tobacco leaves and water according to the weight ratio of tobacco leaves: water = 1:8, soak at 40°C for 2 hours, filter, and wash the filter residue with water several times until the filtrate is colorless. Collect the filter residue, put it in an oven and bake at 80° C. for 4 hours, and pulverize the filter residue to obtain 20-40 mesh tobacco leaf coarse powder.

[0063] Take 10 g of the tobacco leaves obtained above, add 100 ml of ammonia water with a concentration of 20%, place in a 60° C. water bath after sealing, heat for 2 hours, then filter under reduced pressure, discard the filtrate, and keep the filter residue.

[0064] Add 150ml of extraction solvent consisting of 95% methanol and n-hexane to the above filter residue, the mixing volume ratio is 50:50, the ratio of filter residue to extraction solvent (weight:volume) is 1:10, reflux and stir for 3 hours, cool and filter, The filtrat...

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PUM

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Abstract

The invention relates to a method for highly selectively extracting solanesol. The method comprises the following specific processes: soaking and boiling tobacco leaves with deionized water, filtering, baking filtered residue, and crushing to obtain coarse tobacco leaf powder; adding ammonia water into the coarse tobacco leaf powder, performing ammonolysis, and extracting to obtain paste; adding ethyl alcohol into the paste, extracting to obtain a coarse product, and performing post-processing to obtain coarse solanesol; after the coarse solanesol is dissolved, complexing with metal ions in ametal ion aqueous solution to obtain precipitate; and drying the precipitate under reduced pressure, adding a mixed solution of n-hexane and water, oscillating in water bath, separating liquid to obtain an upper organic phase, and drying to obtain white solid, namely, the solanesol, under the reduced pressure. Compared with the conventional process, repeated column chromatography elution is not required to be performed with a large number of organic solvents by the method provided by the invention; high-purity solanesol is obtained by selectively complexing with the solanesol by utilizing silver ions; the process is simple; the product purity is high; the cost is low; and the energy consumption is low.

Description

technical field [0001] The invention relates to a method for extracting solanesol with high selectivity, and belongs to the technical field of separation and purification of effective plant components. Background technique [0002] Solanesol is an unsaturated polyprenyl alcohol, because it contains multiple non-conjugated double bonds, it has a very strong ability to absorb free radicals, and it has antibacterial, anti-inflammatory and hemostatic effects, which are important Pharmaceutical intermediates are an irreplaceable component of ubiquinone drug intermediates, an irreplaceable natural raw material for the synthesis of vitamin K side chains and coenzyme Q10, anti-ulcer drugs, and anti-cancer drugs, as well as synthetic vitamin K2 and anti-cancer drugs. , anti-ulcer drugs, cardiovascular disease and anti-aging drugs coenzyme Q10 raw materials, which is particularly important as the main raw material for the production of coenzyme Q10. Coenzyme Q10 is most commonly used...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C29/74C07C33/02
CPCC07C29/74C07C33/02
Inventor 陈桢禄郑荣豪颜文忠李正勇陈泽鹏
Owner GUANGDONG BRANCH OF CHINA TOBACCO GENERAL
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