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Preparation technology for high-purity medicinal soyabean lecithin

A soybean phospholipid and preparation technology, which is applied in the direction of medical preparations and pharmaceutical formulas of non-active ingredients, can solve the problems of large amount of solvent usage, low purity and yield of phosphatidylcholine and phosphatidylethanolamine, and long product preparation cycle, etc. problems, to achieve low impurity and microbial content, high yield, and overall high effect

Active Publication Date: 2018-05-25
JIANGSU MANSHI BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The research on phospholipids began in Germany in the 1930s, and industrialized in developed countries in the 1960s. The research on phospholipids in my country started relatively late, starting in the 1950s and the 21st century. Afterwards, some progress has been made in the extraction technology of soybean medicinal phospholipids, but the purity and yield of the products phosphatidylcholine (PC) and phosphatidylethanolamine (PE) are still low, and the physical and chemical indicators such as the peroxide value of the product are difficult to meet. National pharmacopoeia standards, large amount of solvent used, long product preparation cycle, etc.

Method used

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Examples

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Comparison scheme
Effect test

preparation example Construction

[0033] The preparation technology of described high-purity medicinal soybean lecithin comprises the following steps:

[0034] a. Solvent degreasing:

[0035] Described solvent degreasing is carried out through the following steps:

[0036] a1: adding the first solvent to the concentrated soybean lecithin, extracting, and obtaining the first residue;

[0037] a2: centrifuging, granulating, and drying the first residue to obtain defatted soybean lecithin.

[0038] Wherein, step a1 is repeated several times before step a2, so that lipid substances in the first residue are removed as much as possible, and more preferably, step a1 is repeated at least twice. After the above steps are taken, the yield of the defatted soybean lecithin is 57.0-65.0%. The yield of defatted soybean lecithin refers to the ratio of defatted soybean lecithin to concentrated soybean lecithin.

[0039] Preferably, the extraction is shear extraction, the shear extraction time is greater than or equal to 1...

Embodiment 1

[0069] S01. Weigh 100 g of concentrated soybean lecithin, add 1000 ml of acetone, shear and extract for 60 min, then stop shearing, settle naturally for 1.5 h, pour off the supernatant and obtain the first residue.

[0070] S02. Add acetone submerged in the first residue to the first residue, shear and extract, repeat the operation 4 times until the solvent acetone upper layer solution is basically colorless, centrifuge the residue, granulate, and dry under low-temperature vacuum for 3 hours to obtain a powder The shape of defatted soybean lecithin is about 60g. The oily acetone is recovered and reused.

[0071] S03. Add ethanol to the powdered soybean lecithin, stir for 60 minutes, then stop stirring, settle naturally for 1.5 hours, and obtain the upper layer solution and the second residue.

[0072] S04. Continue adding ethanol to submerge the second residue into the second residue, repeat the operation 3 times, obtain the upper layer solution, and combine the upper layer s...

Embodiment 2

[0078] S11. Weigh 200 g of concentrated soybean lecithin, add 2000 ml of acetone, shear and extract for 60 min, then stop shearing, settle naturally for 1.5 h, pour off the supernatant and obtain the first residue.

[0079] S12. Add acetone submerged in the first residue to the first residue, shear and extract, repeat the operation 5 times until the solvent acetone upper layer solution is basically colorless, centrifuge the residue, granulate, and dry under low-temperature vacuum for 3 hours to obtain a powder The shape of defatted soybean lecithin is about 120g. The oily acetone is recovered and reused.

[0080] S13. Add ethanol to the powdered soybean lecithin, stir for 60 minutes, then stop stirring, settle naturally for 1.5 hrs, and obtain the upper layer solution and the second residue.

[0081] S14. Continue adding ethanol to submerge the second residue into the second residue, repeat the operation 4 times, obtain the upper layer solution, and combine the upper layer so...

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Abstract

Different from the prior art, a preparation process for high-purity medicinal soyabean lecithin comprises the steps of solvent degreasing, solvent extracting, precipitating, filtering, low-temperaturevacuum desolventizing and drying, wherein purity of phosphatidylcholine in soyabean lecithin is greatly improved through a first solvent extraction process, a second solvent extraction process and asettling process; microorganisms are filtered through a micromembrane, so that the integral yield of high-purity medicinal soyabean lecithin is high, impurity and microorganism content is extremely low, and pharmacopeia standards are met; besides, processes such as adsorbent adsorption purification and adsorbent discoloring can be flexibly added, so that injection-grade high-purity soyabean lecithin is produced.

Description

technical field [0001] The invention relates to a preparation process of high-purity medicinal soybean lecithin. Background technique [0002] Soy lecithin is non-toxic and non-polluting. It is a good natural amphoteric surface active substance. It has the functions of emulsification, dispersion, wetting, demoulding, separation, etc. Refined natural soybean lecithin can be used as an emulsifier as an auxiliary material for the preparation of various pharmaceutical preparations , or for the release of medicines and foods, and sometimes as an auxiliary material for the preparation of drug coatings. [0003] The research on phospholipids began in Germany in the 1930s, and industrialized in developed countries in the 1960s. The research on phospholipids in my country started relatively late, starting in the 1950s and the 21st century. Afterwards, some progress has been made in the extraction technology of soybean medicinal phospholipids, but the purity and yield of the products ...

Claims

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Application Information

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IPC IPC(8): A61K47/24
CPCA61K47/24
Inventor 邓紫新张海燕朱宁
Owner JIANGSU MANSHI BIOTECH
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