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A method for improving the antioxidant capacity of compound Chinese herbal medicine ferulic acid extract

A technology of anti-oxidation ability and Chinese herbal medicine, applied in the separation/purification of carboxylic acid compounds, food ingredients containing natural extracts, anti-toxic agents, etc., can solve the problems of low utilization efficiency, small ferulic acid, difficult extraction, etc., and achieve reduction Waste, significant difference, effect of enhancing drug efficacy

Active Publication Date: 2020-11-24
广州康麦谷医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the content of ferulic acid in herbal medicinal materials is small, and there are problems such as difficult extraction and low utilization efficiency.

Method used

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  • A method for improving the antioxidant capacity of compound Chinese herbal medicine ferulic acid extract
  • A method for improving the antioxidant capacity of compound Chinese herbal medicine ferulic acid extract

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Effect test

Embodiment 1

[0027] A method for improving the antioxidant capacity of the compound Chinese herbal medicine ferulic acid extract. The specific process steps include:

[0028] (1) Chinese herbal medicine compatibility: accurate compatibility according to the quality compatibility ratio of Angelica and Chuanxiong 3:1.6;

[0029] (2) Pretreatment of Chinese herbal medicine: After removing impurities from the raw materials of Angelica sinensis and Chuanxiong, crush them, pass through an 80-150 mesh sieve, and then add pure water 10 times the mass of the raw materials of Chinese herbal medicines, and soak for 40-60 minutes at 40-60℃; add Chinese herbal medicines Cellulase with a raw material mass ratio of 1.5% is extracted with microwave assisted extraction for 2 minutes at a microwave power of 250-400W, and then left to stand for more than 30 minutes;

[0030] (3) Fermentation culture preparation: Add 90 times pure water to the pre-extracted Chinese herbal medicine, and then add 4% glucose, 0.45% amm...

Embodiment 2

[0038] A method for improving the antioxidant capacity of the compound Chinese herbal medicine ferulic acid extract. The specific process steps include:

[0039] (1) Compatibility of Chinese herbal medicine: Accurate compatibility according to the quality compatibility ratio of Angelica and Chuanxiong 3:2;

[0040] (2) Pretreatment of Chinese herbal medicine: After removing impurities from the raw materials of Angelica sinensis and Chuanxiong, crushed, sieved through 80-150 mesh, and then added with pure water 10 times the mass of the raw materials of Chinese herbal medicine, soaked for 40-60 minutes at 40-60℃; adding Chinese herbal medicine Cellulase with a raw material mass ratio of 2% is extracted with microwave assisted extraction for 2 minutes at a microwave power of 250-400W, and then left to stand for more than 30 minutes;

[0041] (3) Fermentation culture preparation: add 90 times pure water to the pre-extracted Chinese herbal medicine, and then add 5% glucose, 0.5% ammonium ...

Embodiment 3

[0049] A method for improving the antioxidant capacity of the compound Chinese herbal medicine ferulic acid extract. The specific process steps include:

[0050] (1) Compatibility of Chinese herbal medicine: Accurate compatibility according to the quality compatibility ratio of Angelica and Chuanxiong at 3:1;

[0051] (2) Pretreatment of Chinese herbal medicine: After removing impurities from the raw materials of Angelica sinensis and Chuanxiong, crush them, pass through an 80-150 mesh sieve, and then add pure water 10 times the mass of the raw materials of Chinese herbal medicines, and soak them at 40-60℃ for 40-60 minutes; Cellulase with a raw material mass ratio of 1% is extracted with microwave assisted extraction for 2 minutes, with a microwave power of 250-400W, and then stand for more than 30 minutes;

[0052] (3) Fermentation culture preparation: Add 90 times pure water to the pre-extracted Chinese herbal medicine, and then add 3% glucose, 0.3% ammonium sulfate, 0.1% potassiu...

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Abstract

The invention discloses a method for improving the oxidation resistance of a ferulic acid extracting solution of a compound Chinese herbal medicine. The angelica sinensis and the ligusticum wallichiiare taken as the raw materials, the modern bioseparation technology, the biological enzymolysis technology, the mixed microbial fermentation technology and the Chinese herbal medicine compatibility application technology are integrated, the ferulic acid extracting solution having high in vitro oxidation resistance is researched and developed, wherein the mixed microbial aerobic fermentation strainmainly comprises thermophilic sporotrichum, saccharomyces cerevisiae and bacillus subtilis; the method provided by the application fully utilizes the ingredient of the ferulic acid in the medicine ofangelica sinensis, the effect of the medicine is strengthened, the waste of the medicine is reduced, the treatment effect of the medicine is improved; the oxidation resistance of the ferulic acid extracting solution is obviously improved through the synergistic effect of the Chinese herbal medicine and the mixed microbial microorganism, the application requirements of the fields like healthcare,medical treatment and foods on the ferulic acid are met, the fermentation process of the technology is simple and efficient, the oxidation resistance and the free radical scavenging capacity of an obtained product are strong, the production cost is low, and the method is easy to implement in the industrial large-scale production.

Description

Technical field [0001] The invention relates to a method for improving the antioxidant capacity of a compound Chinese herbal medicine ferulic acid extract, in particular to a method for preparing a ferulic acid extract with high antioxidant capacity by synergistic fermentation of microorganisms, belonging to the field of biotechnology. Background technique [0002] Ferulic acid (FA for short) has a phenolic acid structure containing unsaturated double bonds and hydroxyl groups. It is one of the effective ingredients in many traditional Chinese medicines such as ferulic acid, chuanxiong, angelica, cohosh, horsetail, etc., and is used For the treatment of cardiovascular and cerebrovascular diseases. Kawabata et al. and Ogiwara et al. reported that ferulic acid can scavenge free radicals, promote the production of free radical scavenging enzymes, increase the activities of glutathione transferase and quinone reductase, and inhibit tyrosinase activity to regulate the human body Phys...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C51/42C07C59/64A61K36/236A61P39/06A23L33/105
CPCA23L33/105A23V2002/00A61K36/232A61K36/236A61K2236/19A61K2236/331C07C51/42C07C59/64A61K2300/00A23V2200/30A23V2250/02A23V2250/21
Inventor 张顺涛李云孙强董书阁
Owner 广州康麦谷医药科技有限公司