Method for recycling cefalexin from enzyme synthesis type cefalexin mother liquor

A technology for cephalexin mother liquor and cephalexin, which is applied in the field of recycling cephalexin, can solve the problems of difficulty in treating waste water to discharge standards, increase the production cost of cephalexin, and large loss of cephalexin, and achieves reduction of related equipment and materials and degradation of degradation. rate and impurity content, reducing the effect of damage and deactivation

Inactive Publication Date: 2018-05-29
SHANXI WEIQIDA PHARMA IND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the high solubility of cephalexin in water, the cephalexin is hydrolyzed and recovered separately, which will cause a large loss in the production of cephalexin, as well as the loss of power and other materials in the early stage of production
Two, use β-naphthol and cephalexin to carry out the method for complexing solids and reclaiming again, because this method uses toxic substances such as β-naphthol and organic solvent, it is more harmful to the human body in actual operation, and contains The waste water of this kind of material is also difficult to handle to discharge standard, has increased the production cost of cephalexin; Three, use macroporous resin adsorption column to carry out recovery and purification to cephalexin, although this method has avoided the use of toxic substances and the hydrolysis of cephalexin Recycling, but the amount of waste liquid to be treated is low. In addition, the method of using macroporous adsorption resin is relatively expensive and the process is relatively cumbersome

Method used

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  • Method for recycling cefalexin from enzyme synthesis type cefalexin mother liquor
  • Method for recycling cefalexin from enzyme synthesis type cefalexin mother liquor
  • Method for recycling cefalexin from enzyme synthesis type cefalexin mother liquor

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] This example is used to illustrate the method for recovering cephalexin from the enzymatic synthesis of cephalexin mother liquor provided by the present invention

[0054] 1) Measure 10L of the cefalexin crystalline mother liquor, and detect in liquid phase that the cephalexin content is 13.4mg / ml, and the temperature of the mother liquor is controlled to be 10.5-11.5°C.

[0055] 2) Start stirring, set the rotating speed to 300rpm, and start to slowly adjust the pH of the feed solution to 1.5 by adding 3M hydrochloric acid dropwise.

[0056] 3) Use the pump to inject the feed into the 230 molecular weight nanofiltration membrane, and adjust the concentration pressure to 3MPa.

[0057] 4) Turn on the temperature control equipment and control the temperature of the membrane at 14.5-15.5°C.

[0058] 5) The concentrated solution is returned to the storage tank, the filtrate is collected in the filtrate collection tank, and concentrated to 8 times the concentration of the c...

Embodiment 2

[0064] This example is used to illustrate the method for recovering cephalexin from the enzymatic synthesis of cephalexin mother liquor provided by the present invention

[0065] 1) Take the same cefalexin crystallization mother liquor as in Example 1, and control the temperature of the mother liquor to be 15.5-16 °C.

[0066] 2) Start stirring, set the rotating speed to 250rpm, and start to slowly adjust the pH of the feed solution to 1.3 by adding 3M hydrochloric acid dropwise.

[0067] 3) Use a pump to inject the feed into the 160 molecular weight nanofiltration membrane, and adjust the concentration pressure to 2.5MPa.

[0068] 4) Turn on the temperature control equipment and control the temperature of the membrane at 10.5-11.5°C.

[0069] 5) The concentrated solution is returned to the storage tank, the filtrate is collected in the filtrate collection tank, and concentrated to 7 times the concentration of the cefalexin crystallization mother liquor.

[0070] 6) Transfer...

Embodiment 3

[0075] This example is used to illustrate the method for recovering cephalexin from the enzymatic synthesis of cephalexin mother liquor provided by the present invention

[0076] 1) Take the same cefalexin crystallization mother liquor as in Example 1, and control the temperature of the mother liquor to be 12.5-13.5°C.

[0077] 2) Start stirring, set the rotating speed to 300 rpm, and start adding 3M hydrochloric acid dropwise to slowly adjust the pH of the feed liquid to 1.8.

[0078] 3) Use a pump to inject the material into the 130 molecular weight nanofiltration membrane, and adjust the concentration pressure to 2MPa.

[0079] 4) Turn on the temperature control equipment and control the temperature of the membrane at 8.5-9.5°C.

[0080] 5) The concentrated solution is returned to the storage tank, the filtrate is collected in the filtrate collection tank, and concentrated to 6 times the concentration of the cephalexin crystalline mother liquor.

[0081] 6) Transfer the c...

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Abstract

The invention relates to the field of recycling of cefalexin, in particular to a method for recycling cefalexin from an enzyme synthesis type cefalexin mother liquor. The method comprises the following steps of (1) separating the acidified cefalexin mother liquor by a film, so as to obtain a concentrated solution of the cefalexin; (2) enabling the obtained concentrated solution of the cefalexin instep (1) to be in contact with an alkaline regulator, and crystallizing, so as to obtain a crystal slurry of the cefalexin. The cefalexin obtained by the method has the characteristics that the purity is high, and the recycling rate is high; the preparation technology is simple, the cost is lower, and more environment-friendly effect is realized; under more preferable conditions, such as the stirring condition, the crystal is separated out, and the stirring phase is set to the phase 2 or phase 3, so that the granularity of the obtained cefalexin crystal is more uniform.

Description

technical field [0001] The invention relates to the field of cephalexin recovery, in particular to a method for recovering cephalexin from an enzymatically synthesized cephalexin mother liquor. Background technique [0002] Cephalexin is a cephalosporin antibiotic that inhibits the synthesis of the cell wall, causing the cell contents to swell to rupture, killing bacteria. [0003] At present, there are three processing methods for the cephalexin mother liquor: 1. Using hydrolase to hydrolyze cephalexin into 7-ADCA and phenylglycine, which are then recovered respectively. Due to the high solubility of cephalexin in water, the hydrolyzed cephalexin is recovered separately, and the loss for the production of cephalexin is relatively large, as well as the loss of power and other materials in the early stage of production. 2. The method of using β-naphthol and cephalexin to be complexed into solid and reclaimed again, this method is harmful to human body in actual operation due...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D501/12C07D501/22
CPCC07D501/12C07D501/22
Inventor 王启斌田伟侯瑞峰陈琪路锐张华秀
Owner SHANXI WEIQIDA PHARMA IND
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