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Vaccine composition for porcine PRV (pseudorabies virus) and PEDV (porcine epidemic diarrhea virus), preparation method and application of vaccine composition

A technology of porcine epidemic diarrhea and porcine pseudorabies virus, applied in the field of animal virology, can solve the problems of general curative effect, high cost, and many medicinal materials, and achieve the effect of high promotion value, low cost, and simple ingredients

Inactive Publication Date: 2018-06-01
熊波
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these therapeutic prescriptions involve many medicinal materials, the cost is high, and the curative effect is general.

Method used

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  • Vaccine composition for porcine PRV (pseudorabies virus) and PEDV (porcine epidemic diarrhea virus), preparation method and application of vaccine composition
  • Vaccine composition for porcine PRV (pseudorabies virus) and PEDV (porcine epidemic diarrhea virus), preparation method and application of vaccine composition
  • Vaccine composition for porcine PRV (pseudorabies virus) and PEDV (porcine epidemic diarrhea virus), preparation method and application of vaccine composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Embodiment 1 (challenge 5 days old young; Symptoms are obvious on the 6th, start to implement treatment):

[0024] (1) Preparation of vaccine solution: Weigh 8g of Caulis Spatholobus, 10g of Lycium barbarum, and 3g of Codonopsis pilosula, add 40mL of distilled water and cook for 20 minutes. After the supernatant is cooled, filter it with a 0.4μm filter membrane to prepare the vaccine solution.

[0025] (2) Preparation of vaccine composition: the preparation method of the composition is: dissolve 2 doses of PRV inactivated vaccine, 2 doses of PRV attenuated live vaccine, and 2 doses of PEDV inactivated vaccine with 2 mL of vaccine solution, and mix them well .

[0026] (3) Application of the vaccine composition: 0.5 mL of the composition was injected subcutaneously and intramuscularly into the piglet's neck, respectively.

Embodiment 2

[0030] Embodiment 2 (challenge 15 days old young; Symptoms are obvious on the 17th, begin to implement treatment):

[0031] (1) Preparation of vaccine solution: Weigh 8g of Caulis Spatholobus, 10g of Lycium barbarum, and 3g of Codonopsis pilosula, add 40mL of distilled water and cook for 20 minutes. After the supernatant is cooled, filter it with a 0.4μm filter membrane to prepare the vaccine solution.

[0032] (2) Preparation of vaccine composition: the preparation method of the composition is: dissolve 2 doses of PRV inactivated vaccine, 2 doses of PRV attenuated live vaccine, and 2 doses of PEDV inactivated vaccine with 2 mL of vaccine solution, and mix them well .

[0033] (3) Application of the vaccine composition: 1.0 mL of the composition was injected subcutaneously and intramuscularly into the piglet's neck, respectively.

Embodiment 3

[0037] Embodiment 3 (25-day-old baby after attacking the virus; symptoms were obvious on the 29th, and treatment was started):

[0038] (1) Preparation of vaccine solution: Weigh 8g of Caulis Spatholobus, 10g of Lycium barbarum, and 3g of Codonopsis pilosula, add 40mL of distilled water and cook for 20 minutes. After the supernatant is cooled, filter it with a 0.4μm filter membrane to prepare the vaccine solution.

[0039] (2) Preparation of vaccine composition: the preparation method of the composition is: dissolve 4 doses of PRV inactivated vaccine, 4 doses of PRV attenuated live vaccine, and 3 doses of PEDV inactivated vaccine with 3 mL of vaccine solution, and mix them well .

[0040] (3) Application of the vaccine composition: 1.5 mL of the composition was injected subcutaneously and intramuscularly into the piglet's neck, respectively.

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Abstract

The invention relates to vaccine composition for a porcine PRV (pseudorabiesvirus) and a PEDV (porcine epidemic diarrhea virus). The vaccine composition comprises 2-4 porcine immunizing doses of PRV inactivated vaccines and attenuated live vaccines and 1-2 porcine immunizing doses of PEDV inactivated vaccines. The invention further provides a preparation method and an application of the vaccine composition in treating PED (porcine epidemic diarrhea). The vaccine composition can effectively induce natural immunity, has obvious effect in treating PED, and has low treatment cost and simple program.

Description

technical field [0001] The invention belongs to the field of animal virology, and relates to a vaccine composition of porcine pseudorabies virus and porcine epidemic diarrhea virus and its application in treating porcine epidemic diarrhea. Background technique [0002] Porcine Epidemic Diarrhea (PED) is an important intestinal disease that endangers the pig industry at present, and is a contagious enteric disease caused by porcine epidemic diarrhea virus (PEDV). Sick pigs are the main source of infection. Pigs of all ages can be infected and the main clinical symptom is watery diarrhea, or diarrhea accompanied by vomiting and dehydration. The severity of symptoms varies with age, and the younger the age, the heavier the symptoms. The sickness rate of suckling pig is very high, 3-4 days after diarrhea occurs in the newborn piglet within one week of age, presents severe dehydration and dies, and the mortality rate can reach 50%, and the highest mortality rate reaches 100%, a...

Claims

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Application Information

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IPC IPC(8): A61K39/245A61K39/215A61K47/46A61P1/12
CPCA61K39/12A61K47/46A61K2039/5252A61K2039/5254A61K2039/54C12N2710/16634C12N2770/20034A61K2300/00
Inventor 熊波胡勇樊力
Owner 熊波