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Electrostatic spinning receiving device for preparing axial orientation tubular tissue engineering material

A receiving device, electrospinning technology, applied in textile and papermaking, filament/thread forming, fiber processing, etc., to achieve the effects of controllable thickness, regular surface, and uniform coating

Pending Publication Date: 2018-06-01
ZHENGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, the problem of fiber delamination still exists in the tissue engineering blood vessels of the prior art and cannot be solved.

Method used

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  • Electrostatic spinning receiving device for preparing axial orientation tubular tissue engineering material
  • Electrostatic spinning receiving device for preparing axial orientation tubular tissue engineering material
  • Electrostatic spinning receiving device for preparing axial orientation tubular tissue engineering material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] An electrospinning receiving device for preparing axially oriented tubular tissue engineering materials, such as Figure 1-4 As shown, it includes a propeller, the propeller is connected with a spinneret 20, an electrostatic high voltage application device is provided at the spinneret 20, the needle of the spinneret 20 is connected to the positive electrode of the electrostatic high voltage application device, and a receiving device is provided below the spinneret 20 . The receiving device includes a pair of receiving pole plates 10 and a reel 13 arranged vertically and parallel to each other. The receiving pole plate 10 is connected to the negative pole of the electrostatic high voltage application device and grounded. The two ends of the receiving pole plate 10 are installed on the bracket 14. It is arranged on the two receiving pole plates 10 and placed on the upper edge of the two receiving pole plates 10 . The distance between two receiving pole plates 10 is 40 mm...

Embodiment 2

[0051] An electrospinning receiving device for preparing axially oriented tubular tissue engineering materials, the structure is the same as that of Example 1, the difference is that: the distance between the two receiving plates 10 is 30 mm; the spinneret 20 to the receiving plate 10 has a distance of 140mm. The cycle of reciprocating motion of the reel 13 is 5 s, the effective stroke is 150 mm, the linear velocity of the reel 13 is 60 mm / s; the rotational angular velocity of the reel 13 is 10 rad / s.

[0052] The surface of the reel 13 is coated with PEO (polyethylene oxide).

[0053] The spinning solution is a polycaprolactone solution with dichloromethane and dimethylformamide as solvents, and the concentration is 16w / v%.

[0054] The parameters of the electrospinning process are set as follows: the propeller propulsion rate is 2.5ml / h, and the electrostatic high voltage is 10kV.

Embodiment 3

[0056] An electrospinning receiving device for preparing axially oriented tubular tissue engineering materials, the structure is the same as that of Example 1, the difference is that: the distance between the two receiving plates 10 is 60mm; the spinneret 20 to the receiving plate The distance of 10 is 200mm. The period of reciprocating motion of the reel 13 is 20s, the effective stroke is 400mm, the linear velocity of the reel 13 is 20mm / s; the rotational angular velocity of the reel 13 is 1rad / s.

[0057] The surface of the reel 13 is coated with PVA (polyvinyl alcohol).

[0058] The spinning solution is a solution of L-polylactic acid with dichloromethane and dimethylformamide as solvents, and the concentration is 10w / v%.

[0059] The parameters of the electrospinning process are set as follows: the propulsion rate of the propeller is 1ml / h, and the electrostatic high voltage is 15kV.

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PUM

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Abstract

The invention discloses an electrostatic spinning receiving device for preparing an axial orientation tubular tissue engineering material, and belongs to the field of tissue engineering material preparation. The electrostatic spinning receiving device comprises an electrostatic spinning spinneret, wherein the receiving device is arranged below the spinneret; the receiving device comprises one pairof receiving polar plates which are vertically arranged and are mutually in parallel, and a scroll; the scroll is vertical to the two receiving polar plates and is overlapped on the upper edges of the two receiving polar plates; the receiving device also comprises a pushing mechanism which pushes the scroll to carry out back and forth movement along the horizontal direction of the scroll; the scroll is also connected with a rotation mechanism. A nanometer fiber tubular tissue engineering material prepared with the device is high in a fiber axial orientation degree, and is used as an artificial blood vessel to be favorable for endothelial cells to grow along the axial orientation and form endothelial tissues which are the same with a true blood vessel.

Description

technical field [0001] The invention belongs to the field of preparation of tissue engineering materials, and in particular relates to an electrospinning receiving device for preparing tubular tissue engineering materials with an axially oriented structure. Background technique [0002] Cardiovascular disease is a serious threat to human health. At present, interventional therapy and vascular bypass surgery are mainly used as treatment methods in clinical practice; because interventional therapy cannot completely avoid the occurrence of restenosis, vascular bypass surgery is still the best choice, but often due to autologous vascular Insufficient sources or certain complex vascular lesions cannot be performed. Therefore, the development of artificial blood vessels or tubular tissue engineering scaffolds that can replace autologous blood vessels has gradually become a research hotspot. [0003] Electrospinning technology has been developed rapidly in the past ten years, ...

Claims

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Application Information

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IPC IPC(8): D01D5/00
CPCD01D5/0061D01D5/0076
Inventor 李倩王小峰孟鑫牛宗武徐轶洋李旭燕蒋晶侯建华江永超马雷郭欣
Owner ZHENGZHOU UNIV
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