A kind of double-layer composite slow-release microsphere loaded with bone formation promoting protein and medicine for eliminating arthritis symptoms and its preparation method
A technology of double-layer composite and sustained-release microspheres, which is applied in the directions of non-active ingredient medical preparations, medical preparations containing active ingredients, and drug combinations, etc., can solve the problem of drug effectiveness, low safety and low patient compliance To prevent the risk of osteoporosis, improve the treatment effect, and reduce the probability of occurrence
Inactive Publication Date: 2020-01-31
青岛市中医医院
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Problems solved by technology
Traditional methods of drug administration also have problems such as drug effectiveness, low safety, and low patient compliance. Therefore, research on drug delivery systems is more urgent
Method used
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Embodiment 1
[0037] A method for preparing double-layer composite slow-release microspheres loaded with bone formation-promoting protein and medicine for eliminating arthritis symptoms, the steps are as follows:
[0038] 1) All raw materials and auxiliary materials used in the production and preparation of double-layer composite slow-release microspheres are inspected and weighed according to the corresponding quality standards, and they meet the specified quality standards.
[0039] 2) Prepare a mixed solution of sodium carboxymethyl alginate, chondroitin and collagen peptide.
[0040] 2.1 Weigh carboxymethyl sodium alginate, chondroitin, and collagen peptide in the homogenizer according to the mass ratio of 3:1:2.
[0041] 2.2 Measure an appropriate amount of 500ml of dichloromethane and pour it into the homogenizer in 2.1.
[0042] 2.3 Under the microwave condition of 50℃, the homogenizer starts to shear and stir, the stirring speed is 70-110rpm, the shearing and stirring time is 1-2h,...
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Abstract
The invention relates to double-layer composite slow-release microspheres loaded with a medicine for promoting bone morphogenetic protein and eliminating arthritis symptoms and a preparation method thereof. PLGA-PCL-MPEG is used as a medicine carrier for the first time, a block copolymer is non-toxic and free of heat sensitivity, has good histocompatibility and has a certain anti-inflammatory effect, and compared with the conventional MPEG-PCL block polymer as a carrier, the PLGA-PCL-MPEG significantly improves convenience of the slow-release medicine and significantly improves the therapeuticeffect. Carboxymethyl alginate can effectively promote formation of BMP (bone morphogenetic protein) and interaction between collagen peptide and chondroitin, not only can improve cartilage buffer toavoid arthritis, but also can avoid calcium loss to prevent osteoporosis risks; moreover, the mechanical strength performance of the prepared double-layer slow-release microspheres is improved, slowrelease and digestion thereof in a body are facilitated, and the coverage rate of inner medicine-loaded microspheres is changed through the adjustment of the pressure, therefore, the medicine releaserate is adjusted.
Description
technical field [0001] The technical field of preparation of the articular cartilage repair material of the present invention. Specifically, it relates to a double-layer composite sustained-release microsphere loaded with bone-forming protein and medicine for eliminating arthritis symptoms and a preparation method thereof. Background technique [0002] At present, joint degeneration and arthritis have become an issue of great concern that seriously affects the quality of life of the elderly population. Studies have found that the prevalence of knee arthritis in people over 65 years old is 10-20%, and the severity of knee arthritis worsens with age. The report of the World Health Organization also shows that since 2003, the population over the age of 60 suffering from arthritis has been increasing worldwide, which shows that the problem of arthritis needs to be solved urgently. [0003] The cartilage in the joints will be lost with age, and will also wear out due to frequen...
Claims
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IPC IPC(8): A61K9/52A61K47/36A61K47/34A61K47/04A61K47/10A61K38/39A61P19/02A61P29/00A61K31/726A61K31/737A61K31/734
CPCA61K9/501A61K9/5031A61K9/5036A61K31/726A61K31/734A61K31/737A61K38/39A61K47/34A61K2300/00
Inventor 刘宝龙张茂全张明珠
Owner 青岛市中医医院