Application of double-layer composite sustained-release microspheres in the preparation of drugs for the prevention and treatment of osteoporosis, arthritis and cartilage restoration
A double-layer composite, sustained-release microsphere technology, applied in the field of preparation of prevention and treatment of osteoporosis, sustained-release microspheres, can solve the problems of low drug effectiveness, low safety, low patient compliance, etc., to prevent osteoporosis Risk of looseness, improved treatment effect, effect of avoiding arthritis
Inactive Publication Date: 2020-02-04
青岛市中医医院
View PDF2 Cites 0 Cited by
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Traditional methods of drug administration also have problems such as drug effectiveness, low safety, and low patient compliance. Therefore, research on drug delivery systems is more urgent
Method used
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View moreImage
Smart Image Click on the blue labels to locate them in the text.
Smart ImageViewing Examples
Examples
Experimental program
Comparison scheme
Effect test
Embodiment 1
[0037] 1) All the raw materials and auxiliary materials used in the production and preparation of double-layer composite slow-release microspheres are inspected and weighed according to the corresponding quality standards, and they meet the specified quality standards.
[0038] 2) Prepare a mixed solution of sodium carboxymethyl alginate, chondroitin and collagen peptide.
[0039] 2.1 Weigh carboxymethyl sodium alginate, chondroitin, and collagen peptide in the homogenizer according to the mass ratio of 3:1:2.
[0040] 2.2 Measure an appropriate amount of 500ml of dichloromethane and pour it into the homogenizer in 2.1.
[0041] 2.3 Under the microwave condition of 50℃, the homogenizer starts shearing and stirring, the stirring rate is 70-110rpm, the shearing and stirring time is 1-2h, and a uniformly mixed solution is formed, and the dispersed solute content in the solution is 500μg / ml. Store in the refrigerator at low temperature for later use and use within 12 hours.
[0...
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More PUM
| Property | Measurement | Unit |
|---|---|---|
| particle size | aaaaa | aaaaa |
| particle size | aaaaa | aaaaa |
Login to View More
Abstract
The invention belongs to medical clinical medication and relates to a sustained release drug applicable to treatment and prevention of osteoporosis and arthritis and recovering cartilage. A PLGA-PCL-MPEG block copolymer is used for preparing the sustained release drug for the first time, has good histocompatibility and a certain anti-inflammation function, is remarkably improved in the aspect of sustained-release drugs as compared with a traditional MPEG-PCL block polymer as a carrier and can effectively improve the treatment effect. Application of carboxymethyl sodium alginate can effectivelypromote generation of BMP (bone morphogenetic protein), collagen peptide interacts with chondroitin, cartilage buffer can be improved, arthritis can be avoided, the anti-pressure capacity required byjoints can be provided, calcium can be kept from losing, and the risk of osteoporosis can be prevented. Double-layer sustained release microspheres are prepared according to the need of drug sustained release, the mechanical strength performance of the microspheres is improved, slow release and digestion in the body are facilitated, and the treatment effect is improved.
Description
technical field [0001] The invention belongs to the field of pharmaceutical engineering. Specifically, it relates to the application of slow-release microspheres in the preparation of medicines for preventing and treating osteoporosis, arthritis and cartilage restoration. Background technique [0002] At present, joint degeneration and arthritis have become an issue of great concern that seriously affects the quality of life of the elderly population. Studies have found that the prevalence of knee arthritis in people over 65 years old is 10-20%, and the severity of knee arthritis worsens with age. The report of the World Health Organization also shows that since 2003, the population over the age of 60 suffering from arthritis has been increasing worldwide, which shows that the problem of arthritis needs to be solved urgently. [0003] The cartilage in the joints will be lost with age, and will also wear out due to frequent joint activities such as walking, running, and jum...
Claims
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More Application Information
Patent Timeline
Login to View More Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/50A61K9/52A61K47/36A61K47/34A61K47/10A61K47/04A61K38/39A61P19/10A61P19/02A61P29/00A61P19/04A61K31/734A61K31/737
CPCA61K9/501A61K9/5031A61K9/5036A61K31/734A61K31/737A61K38/39A61K2300/00
Inventor 张茂全刘宝龙张鸣然
Owner 青岛市中医医院