A kind of preparation method of solid dispersion with whitening and anti-aging effect

A technology of solid dispersion and efficacy, which is applied in skin care preparations, pharmaceutical formulas, and cosmetic preparations, etc. It can solve the problems of decreased bioavailability, decreased solubility, recrystallization, etc., to prevent skin aging and improve stability performance, and the effect of improving the degree of dispersion

Active Publication Date: 2019-09-20
PROYA COSMETICS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the amorphous state (amorphous state) is a metastable state, which is prone to recrystallization and agglomeration during storage, resulting in a decrease in solubility and bioavailability. This phenomenon is called solid dispersion aging, so it is necessary to select appropriate materials to improve the stability of solid dispersions

Method used

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  • A kind of preparation method of solid dispersion with whitening and anti-aging effect
  • A kind of preparation method of solid dispersion with whitening and anti-aging effect
  • A kind of preparation method of solid dispersion with whitening and anti-aging effect

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0061] A preparation method of a solid dispersion with whitening and anti-aging effect, the following steps are adopted:

[0062] A: Weigh 8% ferulic acid, 4% resveratrol, 4% ellagic acid, 8% Burnet saponin II, 6% nordihydroguaiaretic acid, 70% water-soluble polymer by mass percentage carrier, they are mixed and passed through a 60-120 mesh sieve 3-5 times to obtain a physical mixture; the water-soluble polymer carrier is composed of copovidone, polyethylene glycol-vinyl caprolactam-vinyl acetate copolymer, succinate acetate Hypromellose is mixed according to the mass ratio of 3:1:0.1;

[0063] B: Put the physical mixture obtained in step A into the feed port of the hot-melt extruder, set the extrusion temperature to 85-120°C, and after melting and twin-screw extrusion, collect the solid strips at the discharge port;

[0064] C: Pulverize the solid strips obtained in step B, and pass through a 40-80 mesh sieve to obtain a solid dispersion with whitening and anti-aging effects...

Embodiment 2

[0066] A preparation method of a solid dispersion with whitening and anti-aging effect, the following steps are adopted:

[0067] A: Weigh 10% ferulic acid, 8% resveratrol, 6% ellagic acid, 6% Burnet saponin II, 5% nordihydroguaiaretic acid, 65% water-soluble polymer by mass percentage carrier, they are mixed and passed through a 60-120 mesh sieve 3-5 times to obtain a physical mixture; the water-soluble polymer carrier is composed of copovidone, polyethylene glycol-vinyl caprolactam-vinyl acetate copolymer, acid acetic acid Succinic hypromellose is mixed according to the mass ratio of 3:1:0.1;

[0068] B: Put the physical mixture obtained in step A into the feed port of the hot-melt extruder, set the extrusion temperature to 85-120°C, and collect the solid strips at the discharge port after melting and twin-screw extrusion;

[0069] C: Pulverize the solid strips obtained in step B, and pass through a 40-80 mesh sieve to obtain a solid dispersion with whitening and anti-aging...

Embodiment 3

[0071] A preparation method of a solid dispersion with whitening and anti-aging effect, the following steps are adopted:

[0072] A: Weigh 6% ferulic acid, 7% resveratrol, 3% ellagic acid, 6% Burnet saponin II, 2% nordihydroguaiaretic acid, 76% water-soluble polymer by mass percentage carrier, they are mixed and passed through a 60-120 mesh sieve 3-5 times to obtain a physical mixture; the water-soluble polymer carrier is composed of copovidone, polyethylene glycol-vinyl caprolactam-vinyl acetate copolymer, succinate acetate Hypromellose is mixed according to the mass ratio of 3:1:0.1;

[0073] B: Put the physical mixture obtained in step A into the feed port of the hot-melt extruder, set the extrusion temperature to 85-120°C, and collect the solid strips at the discharge port after melting and twin-screw extrusion;

[0074] C: Pulverize the solid strips obtained in step B, and pass through a 40-80 mesh sieve to obtain a solid dispersion with whitening and anti-aging effects....

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Abstract

The invention relates to a preparation method of a solid dispersion with the whitening and anti-aging efficacy. The method is characterized by comprising the following steps that A, through being metered in percentage by mass, 5 to 10 percent of ferulic acid, 4 to 8 percent of resveratrol, 3 to 7 percent of ellagic acid, 4 to 8 percent of ziyuglycoside II, 2 to 6 percent of nordihydroguaiaretic acid and 65 to 80 percent of water-soluble polymer carrier are weighed; after the mixing, the mixture passes through a 60 to 120-mesh sieve for 3 to 5 times to obtain a physical mixture; the water-soluble polymer carrier is formed by mixing copovidone, polyethylene glycol-Vinyl-epsilon-caprolactam-vinyl acetate polymers and hypromellose acetate succinate according to a mass ratio of 3 to 1 to 0.1; B, the physical mixture is fed into a feeding opening of a hot melt extruder; the extrusion temperature is set to be 85 to 120 DEG C; through fusion and twin-screw extrusion, segment cutting is performed at a discharging opening; solid strip-shaped substances are collected; C, the solid strip-shaped substances are crushed and pass through a 40 to 80-mesh sieve; the solid dispersion with the whitening and anti-aging efficacy is obtained. The preparation method has the beneficial effects that four kinds of active substances can be simultaneously loaded; the solubility of the active substances inwater is improved.

Description

technical field [0001] The invention relates to the technical field of cosmetic carrier preparation, in particular to a preparation method of a solid dispersion with whitening and anti-aging effects. Background technique [0002] With the intensification of the aging process of society, anti-aging will become the main demand of consumers for skin care, and the main manifestations of skin aging are collagen loss leading to skin relaxation, wrinkles, facial pigmentation, chloasma, age spots, etc., so Whitening and anti-aging must be combined in order to truly meet the public's anti-aging needs. [0003] Ferulic acid is a derivative of cinnamic acid, which has anti-inflammatory, anti-oxidation and whitening effects, and can effectively inhibit the proliferation of melanocytes, melanin synthesis and tyrosinase activity; resveratrol is a polyphenolic compound with multiple It has the functions of anti-oxidation and anti-aging by scavenging free radicals and preventing oxidative ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/91A61K8/81A61K8/73A61K8/63A61K8/49A61K8/365A61Q19/02A61Q19/08
Inventor 王晗宁蒋丽刚毕永贤黄洁芳王丽娜席长洪
Owner PROYA COSMETICS
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