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Pharmaceutical composition for preventing and treating femoral head necrosis and preparation method thereof

A technology of femoral head necrosis and composition, which is applied in the field of pharmaceutical composition for preventing and treating femoral head necrosis and its preparation, which can solve the problems of low active ingredient content, rough preparation process, and complicated medicinal ingredients, and achieve short treatment cycle and effective treatment of femoral head. Bone necrosis, the effect of reducing the risk of contamination

Active Publication Date: 2021-01-29
GUANGDONG ANNOL PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the Western medicine methods for the treatment of femoral head necrosis mostly adopt drilling decompression, blood vessel grafting, free bone grafting, osteotomy, artificial joint replacement and other methods. Great pain for patients, often unsatisfactory results
However, for different syndromes of femoral head necrosis and different periods of disease progression, better therapeutic effect can be obtained by using syndrome differentiation and medication, such as publication numbers CN 104257953 A, CN 104274606 A, CN 104274640 A, CN104257851 A, CN 104306689 The Chinese patent application of A discloses respectively the traditional Chinese medicine composition for treating femoral head necrosis of wind-cold-damp arthralgia type, qi and blood deficiency type, qi stagnation and blood stasis type, kidney deficiency and blood stasis type, and phlegm-damp blocking collateral type. It is made of more than a dozen medicinal materials, and at most it is made of more than 20 or 30 medicinal materials. The medicinal ingredients are complex, the preparation process is rough, and the content of active ingredients is low. It is only effective for a certain syndrome. The effect is relatively simple

Method used

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  • Pharmaceutical composition for preventing and treating femoral head necrosis and preparation method thereof
  • Pharmaceutical composition for preventing and treating femoral head necrosis and preparation method thereof
  • Pharmaceutical composition for preventing and treating femoral head necrosis and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Embodiment 1 Bozi kernel pretreatment

[0042] (1) After mixing the cypress kernels and the porous starch in a weight ratio of 1:0.4, place them in a pressure alternation generator, and continuously feed the mixed liquid steam. The mixed liquid contains 75% v / v of absolute ethanol, Water 10% v / v, phytic acid ester 15% v / v, and the ratio of the mixed liquid to the cypress kernel is 1g / 40mL, then apply an alternating pressure of 0-15MP, treat for 25min, the pressure The increasing or decreasing frequency is 3MP / 5min, and then dried at a low temperature of 50°C to obtain material A, which is set aside;

[0043] (2) Put the material A treated in step (1) under an ultraviolet lamp for irradiating treatment for 30 minutes, then wash with alcohol and water in sequence, repeat this 4 times, and dry at a low temperature at 50°C to obtain Baiziren .

Embodiment 2

[0052] Example 2 Evaluation of the Degradation Effect of Aflatoxin in Baiziren

[0053] The aflatoxin and fat content of the Baizi kernels treated by the methods of Example 1 and Comparative Examples 1 and 2 were tested respectively, and the results are shown in Table 1 below.

[0054] Table 1 The effect of pretreatment on the degradation of aflatoxin and fat level in Baiziren

[0055]

[0056] It can be seen from Example 1 that the pretreatment step of the cypress kernels provided by the present invention can effectively degrade aflatoxins B1 and B2, so that the treated cypress kernels are almost free of aflatoxins B1 and B2, and the degradation rate reaches more than 99.69%. And it has little effect on the fat level of Baiziren, and does not affect the nutrients of Baiziren.

Embodiment 3

[0057] Embodiment 3 is used for preventing and treating the preparation of the pharmaceutical composition of femoral head necrosis

[0058] Formula: 400 parts of rehmannia glutinosa, 450 parts of yam, 450 parts of Baiziren, 300 parts of tortoise shell, 250 parts of Polygonum multiflorum and 150 parts of angelica.

[0059] Preparation:

[0060] (1) Take by weighing the Chinese yam of prescription 1 / 3 amount, be ground into fine powder, set aside;

[0061] (2) Mix the remaining 2 / 3 of yam with Rehmannia glutinosa, Boziren, Guijia, Radix Polygoni Multiflori and Angelica, then put it in a multi-functional extraction tank and add water to decoct twice, adding 6 times the amount of water for the first time , for the second time, add 5 times the amount of water of the medicinal materials, decoct for 2 hours each time, and collect volatile oil at the same time;

[0062] (3) Filter the two decoctions, combine the decoctions, concentrate the filtrate to a relative density of 1.10 at 7...

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Abstract

The invention relates to the technical field of traditional Chinese medicines, in particular to a pharmaceutical composition for preventing and treating femoral head necrosis and a preparation method thereof. The pharmaceutical composition comprises the following preparation raw materials: Rehmannia glutinosa, Chinese yam, Baiziren, tortoise shell, Polygonum multiflorum and Angelica sinensis. Further, the preparation raw materials of the pharmaceutical composition also include Epimedium, Eucommia, Morinda officinalis, Dipsacus and Drynaria. The pharmaceutical composition provided by the invention has reasonable prescriptions, scientific proportioning, each component complements each other, has a better synergistic gain effect, has a significant effect on preventing and treating femoral head necrosis, and has a fast curative effect. The total effective rate for treating femoral head necrosis reaches 97.5%. The rate reaches 87.5%, and has the advantages of definite curative effect, no toxic and side effects, and high cure rate.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicines, in particular to a pharmaceutical composition for preventing and treating necrosis of the femoral head and a preparation method thereof. Background technique [0002] The full name of femoral necrosis is aseptic femoral head necrosis or ischemic femoral head necrosis. Femoral head necrosis is caused by a variety of causes of poor local blood supply of the femoral head, resulting in further bone cell ischemia, necrosis, trabecular fracture, A lesion in which the femoral head collapses. Femoral head necrosis is a common clinical orthopedic disease with high disability rate. Necrosis of the femoral head is divided into two categories: traumatic and non-traumatic. The former is mainly caused by hip trauma such as femoral neck fracture and hip dislocation. The latter is mainly caused by the application of corticosteroids and alcoholism in my country. At present, research result...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8945A61P19/08A61K35/586
CPCA61K35/586A61K36/126A61K36/14A61K36/185A61K36/232A61K36/296A61K36/46A61K36/704A61K36/746A61K36/804A61K36/8945A61K2236/331A61K2236/39A61K2236/51A61K2300/00
Inventor 潘翠萍曹祺侯木燕陈锐东
Owner GUANGDONG ANNOL PHARM CO LTD