Benzylisoquinoline compound, preparation method and application
A technology of benzylisoquinolines and compounds, applied in the fields of active ingredients of heterocyclic compounds, organic chemistry, drug combination, etc., can solve severe allergies and other problems, and achieve the effect of short duration of muscle relaxation and rapid disappearance of muscle relaxation
Inactive Publication Date: 2018-07-06
SICHUAN DAOZHEN TECH CO LTD
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The structural formula is shown in the description, wherein Ar1, Ar2, Ar3 and Ar4 are non-substituted or substituted aryl groups; R is H or C1-5 alkyl group; R1, R2, R3 and R4 can be independent H orC1-5 alkyl groups; in addition, R1 and R2 can form C2-5 ene groups commonly, and R3 and R4 can form C2-5 ene groups commonly; B1 is C1-9 substituted or non-substituted, saturated or unsaturated alkylene groups, and the skeleton of B1 can contain heteroatoms such as O; B2 is C1-8 substituted or non-substituted, saturated or unsaturated alkylene groups, and the skeleton of B2 can contain heteroatomssuch as O; X is O or CH2 or NR5, wherein R5 is H or C1-5 alkyl groups; Y is O or CH2 or C(O)O; S is pharmaceutically-acceptable anions such as bromide ions, sulfonate ions. A stereoisomer with a structure shown in a formula (I), a stereoisomer mixture or pharmaceutically-acceptable salts and a pharmaceutical composition formed by the pharmaceutically-acceptable salts and pharmaceutically-acceptable carriers can generate a neuromuscular junction blocking effect and can be applied in the field of preparation of medicines for muscular relaxation.
Organic chemistryMuscular disorder +3
Block effectBromide ions +6
- Experimental program(4)
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