Benzylisoquinoline compound, preparation method and application
A technology of benzylisoquinolines and compounds, applied in the fields of active ingredients of heterocyclic compounds, organic chemistry, drug combination, etc., can solve severe allergies and other problems, and achieve the effect of short duration of muscle relaxation and rapid disappearance of muscle relaxation
Inactive Publication Date: 2018-07-06
SICHUAN DAOZHEN TECH CO LTD
0 Cites 11 Cited by
AI-Extracted Technical Summary
Problems solved by technology
View more
Abstract
The structural formula is shown in the description, wherein Ar1, Ar2, Ar3 and Ar4 are non-substituted or substituted aryl groups; R is H or C1-5 alkyl group; R1, R2, R3 and R4 can be independent H orC1-5 alkyl groups; in addition, R1 and R2 can form C2-5 ene groups commonly, and R3 and R4 can form C2-5 ene groups commonly; B1 is C1-9 substituted or non-substituted, saturated or unsaturated alkylene groups, and the skeleton of B1 can contain heteroatoms such as O; B2 is C1-8 substituted or non-substituted, saturated or unsaturated alkylene groups, and the skeleton of B2 can contain heteroatomssuch as O; X is O or CH2 or NR5, wherein R5 is H or C1-5 alkyl groups; Y is O or CH2 or C(O)O; S is pharmaceutically-acceptable anions such as bromide ions, sulfonate ions. A stereoisomer with a structure shown in a formula (I), a stereoisomer mixture or pharmaceutically-acceptable salts and a pharmaceutical composition formed by the pharmaceutically-acceptable salts and pharmaceutically-acceptable carriers can generate a neuromuscular junction blocking effect and can be applied in the field of preparation of medicines for muscular relaxation.
Application Domain
Organic chemistryMuscular disorder +3
Technology Topic
Block effectBromide ions +6
Image
Examples
- Experimental program(4)
Example Embodiment
Example Embodiment
Example Embodiment
PUM


Description & Claims & Application Information
We can also present the details of the Description, Claims and Application information to help users get a comprehensive understanding of the technical details of the patent, such as background art, summary of invention, brief description of drawings, description of embodiments, and other original content. On the other hand, users can also determine the specific scope of protection of the technology through the list of claims; as well as understand the changes in the life cycle of the technology with the presentation of the patent timeline. Login to view more.