Epoxy-containing skeleton nitrile compound and synthesis method thereof
A synthesis method and technology for nitrile compounds, applied in the direction of organic chemistry, etc., can solve the problems such as furan compounds that have not yet been found
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Embodiment 1
[0076] The reaction route is:
[0077]
[0078] Specific steps are as follows:
[0079] S1: At room temperature, add 100mmol of the compound of the above formula (1), 150mmol of the compound of the above formula (2), 10mmol of palladium acetate, 5mmol of 2,2'-bipyridine, 250mmol of silver acetate and 600mmol of trifluoro to an appropriate amount of organic solvent tetrahydrofuran (THF) Acetic acid, then stirred and warmed up to 70 ° C, and stirred and reacted at this temperature for 40 hours;
[0080] After the reaction was finished, the reaction mixture was poured into a sufficient amount of ethyl acetate, then washed with saturated brine, and the organic layer and the water layer were separated. After the water layer was fully extracted with ethyl acetate, the organic layers were combined (after washing with saturated brine). The organic layer and the organic layer obtained by ethyl acetate extraction), with anhydrous Na 2 SO 4 Drying, distillation under reduced pressu...
Embodiment 2
[0086] The reaction route is:
[0087]
[0088] Specific steps are as follows:
[0089]S1: At room temperature, add 100mmol of the compound of the above formula (1), 250mmol of the compound of the above formula (2), 3mmol of palladium acetate, 15mmol of 2,2'-bipyridine, 150mmol of silver acetate and 1000mmol of trifluoro to an appropriate amount of organic solvent tetrahydrofuran (THF) Acetic acid, then stirred and warmed up to 100 ° C, and stirred and reacted at this temperature for 20 hours;
[0090] After the reaction was finished, the reaction mixture was poured into a sufficient amount of ethyl acetate, then washed with saturated brine, and the organic layer and the water layer were separated. After the water layer was fully extracted with ethyl acetate, the organic layers were combined (after washing with saturated brine). The organic layer and the organic layer obtained by ethyl acetate extraction), with anhydrous Na 2 SO 4 Drying, distillation under reduced press...
Embodiment 3
[0096] The reaction route is:
[0097]
[0098] Specific steps are as follows:
[0099] S1: At room temperature, add 100mmol of the compound of the above formula (1), 200mmol of the compound of the above formula (2), 6.5mmol of palladium acetate, 10mmol of 2,2'-bipyridyl, 200mmol of silver acetate and 800mmol of three Fluoroacetic acid, then stirred and heated to 85 ° C, and stirred and reacted at this temperature for 30 hours;
[0100] After the reaction was finished, the reaction mixture was poured into a sufficient amount of ethyl acetate, then washed with saturated brine, and the organic layer and the water layer were separated. After the water layer was fully extracted with ethyl acetate, the organic layers were combined (after washing with saturated brine). The organic layer and the organic layer obtained by ethyl acetate extraction), with anhydrous Na 2 SO 4 Drying, distillation under reduced pressure, the residue is eluted by flash column chromatography (with a m...
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