Application of bacterial strain in preparation for preventing and treating mycotic and bacterial vaginitis

Abstract

The invention provides a strain(lactobacillus plantarum LP-A3), a screening method, and an application of the strain in the prevention and treatment of mycotic and bacterial vaginitis by regulating the floras in vaginas. The strain is saved in China General Microbiological Culture Collection Center, CGMCC. The address of CGMCC is No.3 building, No.1 yard, Beichen west road, Chaoyang district, Beijing. The preservation number is CGMCC No. 14570. The preservation date is 29th, August, 2017. LP-A3 is separated from secretion of vaginas of strictly selected females; and the research results show that LP-A3 adapts to the environment of vaginas, can reach vaginas through oral administration, has high activity and a strong colonization performance in vaginas, can better adjust the floras in vaginas, and is capable of co-existing with and mutually benefiting other probiotics. The provided bacterial strain can obviously prevent and relieve vaginitis and has a wider application range.

Description

technical field [0001] The invention belongs to the technical field of microbes, and more specifically relates to the application of bacterial strains in preparations for preventing and treating mycotic and bacterial vaginitis. Background technique [0002] Vaginitis is an inflammation of the vaginal mucosa and submucosal connective tissue, and is a common disease in gynecological clinics. Common vaginitis includes bacterial vaginosis, fungal vaginitis, trichomonas vaginitis, senile vaginitis, etc. In recent years, the incidence of bacterial vaginosis and fungal vaginitis has been on the rise. The common pathogens of bacterial infection are mixed pathogenic bacteria, such as: Gardnerella vaginalis, Escherichia coli [0003] (Escherichia coli), Pseudomonas aeruginosa, Staphylococcus aureus [0004] (Staphylococcus aureus) and Streptococcus (Streptococcus), mixed type of pathogenic bacteria are suitable for growth in an alkaline environment (pH>4.5); the more common patho...

AI Technical Summary

Problems solved by technology

However, the current products have: the strains have poor digestion resistance, only a small amount survives after oral administration, and the number of viable bacteria is low, so they cannot play a probiotic effect; the colonization ability is poor, and they are quickly metabolized by the human body after reaching the target site, and the effect is not long-lasting; antibacterial effect Weak, it only works against certain bacteria, and the effect is not obvious, etc.

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