Application of bacterial strain in preparation for preventing and treating mycotic and bacterial vaginitis

A technology for fungal vaginitis and vaginitis, applied in the field of microorganisms, can solve the problems of poor digestion resistance of strains, unable to play a probiotic effect, weak bacteriostatic effect, etc., to achieve strong bacteriostatic effect, good regulation of vaginal flora, effects that are not easy to repeat

Active Publication Date: 2018-07-20
天津科睿恒生物科技有限公司
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  • Abstract
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  • Application Information

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Problems solved by technology

However, the current products have: the strains have poor digestion resistance, only a small amount survives after oral administration, and the number of viable bacteria is low, so they cannot play a probiotic effect; the colonization ab

Method used

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  • Application of bacterial strain in preparation for preventing and treating mycotic and bacterial vaginitis
  • Application of bacterial strain in preparation for preventing and treating mycotic and bacterial vaginitis
  • Application of bacterial strain in preparation for preventing and treating mycotic and bacterial vaginitis

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Embodiment Construction

[0021] Below in conjunction with the examples, the present invention is further described, the following examples are illustrative, not limiting, and the protection scope of the present invention cannot be limited by the following examples.

[0022] The invention provides a screening of Lactobacillus plantarum LP-A3 and its application in the prevention and treatment of mycotic and bacterial vaginosis by regulating vaginal flora, wherein the name of Lactobacillus plantarum is LP-A3, and the depository unit is: China Microbiology General Microbiology Center of the Culture Collection Management Committee, the preservation address is: No. 3, No. 1, Beichen West Road, Chaoyang District, Beijing, the preservation number is: CGMCC No.14570, the preservation date is: August 29, 2017, and the classification is named: Lactobacillus plantarum.

[0023] The strain LP-A3 was isolated from healthy unmarried female athletes aged 18-22 (Beijing, China). It has excellent acid and bile salt re...

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Abstract

The invention provides a strain(lactobacillus plantarum LP-A3), a screening method, and an application of the strain in the prevention and treatment of mycotic and bacterial vaginitis by regulating the floras in vaginas. The strain is saved in China General Microbiological Culture Collection Center, CGMCC. The address of CGMCC is No.3 building, No.1 yard, Beichen west road, Chaoyang district, Beijing. The preservation number is CGMCC No. 14570. The preservation date is 29th, August, 2017. LP-A3 is separated from secretion of vaginas of strictly selected females; and the research results show that LP-A3 adapts to the environment of vaginas, can reach vaginas through oral administration, has high activity and a strong colonization performance in vaginas, can better adjust the floras in vaginas, and is capable of co-existing with and mutually benefiting other probiotics. The provided bacterial strain can obviously prevent and relieve vaginitis and has a wider application range.

Description

technical field [0001] The invention belongs to the technical field of microbes, and more specifically relates to the application of bacterial strains in preparations for preventing and treating mycotic and bacterial vaginitis. Background technique [0002] Vaginitis is an inflammation of the vaginal mucosa and submucosal connective tissue, and is a common disease in gynecological clinics. Common vaginitis includes bacterial vaginosis, fungal vaginitis, trichomonas vaginitis, senile vaginitis, etc. In recent years, the incidence of bacterial vaginosis and fungal vaginitis has been on the rise. The common pathogens of bacterial infection are mixed pathogenic bacteria, such as: Gardnerella vaginalis, Escherichia coli [0003] (Escherichia coli), Pseudomonas aeruginosa, Staphylococcus aureus [0004] (Staphylococcus aureus) and Streptococcus (Streptococcus), mixed type of pathogenic bacteria are suitable for growth in an alkaline environment (pH>4.5); the more common patho...

Claims

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Application Information

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IPC IPC(8): A61K35/747A61P15/02A61P31/10
CPCA61K35/747
Inventor 杨华曹琬宜陈莎张凡奇马晴晴周马溶
Owner 天津科睿恒生物科技有限公司
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