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Synthesis process of methylprednisolone

A technology of methylprednisolone and synthesis process, which is applied in the field of methylprednisolone synthesis process, can solve the problems of slow onset of action, and achieve the effects of reducing production cost and improving yield and purity

Inactive Publication Date: 2018-07-20
YUEYANG HUANYU PHARMA
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  • Abstract
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  • Claims
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Problems solved by technology

Acetate is a suspension, and the onset of action is slow after injection, and the effect is long-lasting

Method used

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  • Synthesis process of methylprednisolone
  • Synthesis process of methylprednisolone
  • Synthesis process of methylprednisolone

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Embodiment Construction

[0017] The present invention is further described below through specific examples, but the present invention is not limited only to the following examples. Within the scope of the present invention or without departing from the content, spirit and scope of the present invention, changes, combinations or substitutions to the present invention are obvious to those skilled in the art and are included in the scope of the present invention Inside.

[0018] A kind of synthesis process of methylprednisolone, take ethylene glycol, triethyl orthoformate, Platt's debrominated product, PTS as raw material, at first through ketal reaction, centrifuge dry, dry to obtain ketal product, then reduction reaction, Water analysis, centrifugation, drying, and drying to obtain the reduced product, then epoxy reaction, centrifugation, and drying to obtain the epoxy product, after gravitational reaction, adding water, water analysis, centrifugation, drying, upper drying, and drying to obtain the Gri...

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Abstract

The invention provides a synthesis process of methylprednisolone. According to the process, glycol, triethyl orthoformate, 21-deoxy cortisone and PTS are used as raw materials; firstly, through ketalreaction, centrifugation, spin-drying and baking, ketal materials are obtained; then, reduction reaction is performed; water is added for water separation; centrifugation, spin-drying and drying are performed to obtain reduzates; next, epoxy reaction, centrifugation and drying are performed to obtain epoxides; through Grignard reaction, water addition for water separation, centrifugation, spin-drying, baking and drying, Grignard materials are obtained; then, through biological fermentation, iodination reaction, centrifugation, filtering, spin-drying, replacement reaction, centrifugation, and spin-drying, a refined product is obtained; finally, through hydrolysis reaction, centrifugation, spin-drying and baking to the constant weight, a finished product is obtained. The synthesis process has the advantages that the yield and the purity of the product are improved; the production cost is reduced.

Description

technical field [0001] The invention relates to the field of medicine preparation, in particular to a synthesis process of methylprednisolone. Background technique [0002] Methylprednisolone has strong anti-inflammatory effect and weak sodium retention effect, and its anti-inflammatory effect is 7 times that of cortisone; methylprednisolone sodium succinate is a water-soluble derivative of prednisolone, which is transformed into It is methylprednisolone, which can be injected. It has a quick-acting effect and a medium maintenance time. It is the preferred drug for treating inflammation and allergy. Acetate is a suspension, with slow onset and long-lasting effects after injection. Methylprednisolone is an intermediate-acting glucocorticoid. The effect is the same as that of prednisolone, its anti-inflammatory effect is 3 times that of the latter, its glucose metabolism effect is 10 times stronger than that of hydrocortisone, its water and sodium retention effect is weak, a...

Claims

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Application Information

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IPC IPC(8): C07J5/00
CPCC07J5/0053
Inventor 徐润星
Owner YUEYANG HUANYU PHARMA
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