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Combined compositions for controlling blood sugar levels, hepatoprotection, and for prevention and treatment of related medical conditions

A technology of blood sugar level and composition, applied in the directions of drug combination, medical preparations containing active ingredients, application, etc., can solve the problems of hindering liver cell regeneration, aggravating alcoholic liver damage, malnutrition, etc.

Inactive Publication Date: 2018-07-31
NATURAL SHIELD ISRAEL 2016 LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although genetic factors may contribute to alcoholism and alcoholic liver disease, malnutrition, especially vitamin A and E deficiencies, can exacerbate alcohol-induced liver injury by hindering hepatocyte regeneration [8]

Method used

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  • Combined compositions for controlling blood sugar levels, hepatoprotection, and for prevention and treatment of related medical conditions
  • Combined compositions for controlling blood sugar levels, hepatoprotection, and for prevention and treatment of related medical conditions
  • Combined compositions for controlling blood sugar levels, hepatoprotection, and for prevention and treatment of related medical conditions

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0164] The term BCD denotes the preparation of BCD in ethanol (1:1 v / v), which when emulsified in PBS represents 30% v / v. According to some specific embodiments, BCD can be dissolved in EtOH or combined with EtOH. More specifically, the ratio of BCD to E(EtOH) may range between about 1:0 to 1:999999, more specifically, 1:1 to 1:99999, 1:1 to 1:9999, 1:1 to 1:999, 1:1 to 1:99, 1:1 to 1:9. However, it should be understood that the BCD of the present invention may be prepared or dissolved in any other solvent.

[0165] It should be noted that the compositions of the present invention may comprise any combination, including partial combinations, of the aforementioned components.

[0166] As mentioned above, the combined composition of the present invention comprises at least two active agents, in particular at least one of natural or synthetic phytosterols, lunasin peptides and extracts from Moringa plants or any combination thereof, and any Selected at least one SE, β-glycolip...

Embodiment 1

[0611] Effects of phytosterol (CardioAid) and lunasin on HFD mice

[0612] A high-fat diet (HFD) is widely used to produce hepatic steatosis and nonalcoholic steatohepatitis (NASH) in experimental animals. NASH was induced by feeding mice with HFD starting from 10 weeks of age as described above. Additionally, CardioAid and Lunasin were administered to mice as described above.

[0613] Briefly, three groups of mice (n=6 in each group) were examined. Mice were fed orally by gavage (except HFD) three times a week for 25 weeks as follows: Group A received no treatment and was used as a control; Group B received CardioAid (3 mg / mouse / feed) and Group C received Lunasin (LunaRichX, 3 mg / mouse / feed). The effect of treatment on the systemic immune system was determined by FACS analysis and by measuring the levels of serum cytokines. In addition, liver enzyme levels, liver histology, total body fat, liver triglycerides and glucose levels were analyzed as described above.

[0614] ...

Embodiment 2

[0627] Administration of CardioAid prevents rise in blood sugar levels when added to high-sugar drinks

[0628] chocolate drink

[0629] As detailed above, the effect of CardioAid on blood glucose levels was examined in mice administered a high-sugar soft drink. Briefly, male C57Bl / 6 mice (11-12 weeks old) were obtained from Harlan Laboratories (Jerusalem, Israel) and given standard laboratory chow and water ad libitum.

[0630] Divide the mice into the following experimental and control groups:

[0631] Table 1: Experimental groups

[0632] Group

treat

Quantity / mouse

A

Chocolate drink + DDW 1:1

250μl

B

Choco-DDW+CardioAid

250μl+1mg

[0633] Mice were administered a chocolate drink prepared as described above with or without CardioAid, followed by an overnight fast. All animals were followed for 3 hours by measuring serum blood glucose at the following time points: 0, 15, 30, 60, 90, 120, 180 min.

[0634] Such as Figure...

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Abstract

The invention relates to compositions and methods using various combinations of at least one of phytosterols, lunasin peptide and plant extracts, optionally in combination with at least one of, soy extracts, beta-glycolipides and different adjuvants such as, castor oil, polyethylene glycol, or beta-cyclo dextrin, for controlling blood sugar levels, altered insulin resistance and / or hepatic function in a subject, treating an immune related disorder, treating liver damage and restoring liver function, treating, preventing, ameliorating, reducing or delaying the onset of acute or chronic toxic effect of a drug, and for enhancing the therapeutic effect of a therapeutic agent in a subject.

Description

field of invention [0001] The present invention relates to therapeutic compositions, beverages and food supplements having a combination of enhanced ability to control blood glucose levels, altered insulin resistance and protect and restore liver function. Compositions of the invention are particularly useful for a range of diseases including pre-diabetes, diabetes and related conditions. [0002] background reference [0003] 1. Rippe JM, Angelopoulos TJ. Sugars, obesity, and cardiovascular disease: results from recent randomized control trials. Eur J Nutr. 2016Jul 14 [0004] 2.Hamel C, Do sugar-sweetened beverages cause adverse health outcomes in adults? A systematic review protocol. Syst Rev. 2014 Sep 23; 3:108. [0005] 3. Ludwig DS et al. Relation between consumption of sugar-sweetened drinks and childhood obesity: a prospective, observational analysis. The Lancet, Vol. 357, No. 9255, pp. 505–508 (2001). [0006] 4. Schulze MB et al. Sugar-sweetened beverages, weight...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L33/11A61K31/575A61P3/08A61K31/7028A61P3/10A61P1/16A61P37/00A61K36/48A61K31/685
CPCA61K31/575A61K31/685A61K31/7028A61K36/48A61K2236/00A23L33/11A61K45/06A61K38/168A61K36/185A23L33/18A23L33/105A61P1/16A61P3/10A23L2/52A23V2002/00A61K2300/00A23V2200/328A23V2250/20A23V2250/2136A23V2250/55A23L33/40A61K38/02
Inventor Y·伊兰
Owner NATURAL SHIELD ISRAEL 2016 LTD
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