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Method of preparing nucleus pulposus replantation body in combination with three-dimensional printing technology

A technology of three-dimensional printing and nucleus pulposus, which is applied in prosthetics, medical science, tissue regeneration, etc., to achieve good mechanical properties, long shelf life, and good biocompatibility

Pending Publication Date: 2018-08-03
SHANGHAI NINTH PEOPLES HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Combining three-dimensional printed polycaprolactone scaffolds with anti-inflammatory treated nucleus pulposus waste, and then replanting them in situ will certainly have better clinical application potential in the treatment of intervertebral disc degeneration, and there is no relevant report yet

Method used

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  • Method of preparing nucleus pulposus replantation body in combination with three-dimensional printing technology
  • Method of preparing nucleus pulposus replantation body in combination with three-dimensional printing technology
  • Method of preparing nucleus pulposus replantation body in combination with three-dimensional printing technology

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Experimental program
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Effect test

preparation example Construction

[0034] S1. Preparation of elastomeric scaffold:

[0035] 1. Selection of materials: Measure an appropriate amount of polycaprolactone material and wait for the next step;

[0036] 2. Establishment of 3D model: Use 3D printing software to build a 3D model, then export the 3D model, save it, and wait for the next step;

[0037] 3. Printing of the 3D model: Add the polycaprolactone material measured in step 1 into the barrel of the 3D printing device, and then heat the polycaprolactone material in the barrel until the polycaprolactone material is completely After melting, start the printing program, and print the polycaprolactone material according to the three-dimensional model established in step 2 through the three-dimensional printing equipment, and wait until the printing is completed to obtain the polycaprolactone elastomer support, wherein the elastic support has a certain pore structure , waiting for the next step;

[0038] 4. Treatment of the elastomer support: use cob...

Embodiment 1

[0054] Using 3D printing software to construct a 3D model, the shape is cylindrical, with a diameter of 3 mm and a height of 5 mm. Export the stl format file and save it. Add polycaprolactone into the three-dimensional printing barrel, heat it to 100-150°C, and after it is completely melted, start the printing program to print and form. The diameter of the print head is 150 μm, the air pressure of the barrel during printing is 800KPa, and the layer height is 150 μm. The print path angle is 0 / 60. The printed polycaprolactone elastomer scaffold was sterilized by cobalt-60 radiation and stored in a dry, low-temperature sterile environment.

[0055] The nucleus pulposus waste removed during the operation was rinsed, shredded, and treated with anti-inflammation. In the washing step, the waste of the nucleus pulposus of the intervertebral disc is washed away with normal saline, and repeated several times. In the shredding step, the nucleus pulposus waste is shredded sufficiently...

Embodiment 2

[0059] The radial mechanical performance test was carried out on the three-dimensionally printed elastomeric stent printed in Example 1. The test used a universal mechanical tester to cyclically compress the stent in the radial direction. During the test, the maximum deformation was 60%, and the compression rate was 10cm / min. A total of 100 cycles were performed. The stress-strain cycle curve is as figure 2 As shown, after up to 100 compression cycles, the scaffold still maintains good mechanical properties.

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Abstract

The invention relates to the field of three-dimensional printing preparation of nucleus pulposus replantation bodies, in particular to a method of preparing a nucleus pulposus replantation body in combination with a three-dimensional printing technology. According to the method of preparing the nucleus pulposus replantation body in combination with the three-dimensional printing technology, a polycaprolactone elastomer support is prepared by three-dimensional printing to serve as a mechanical support material of a nucleus pulposus implant; nucleus pulposus waste is treated to form a compositesupport with a polycaprolactone elastomer; and the support is good in mechanical property and biocompatibility, and contains a nucleus pulposus extracellular matrix and nucleus pulposus cells. The method of preparing the nucleus pulposus replantation body through the three-dimensional printing to treating degeneration of the lumbar intervertebral disc can obtain a series of polycaprolactone elastomer support products with different specifications via printing; the products are dry solids, and are easy to store and long in storage life; and at the same time, the nucleus pulposus replantation body can be replanted after immediate treatment intraoperatively by a replantation method after compositing of the nucleus pulposus waste and the polycaprolactone elastomer support.

Description

technical field [0001] The invention relates to the field of preparation of nucleus pulposus implants by three-dimensional printing, in particular to a method for preparing nucleus pulposus implants combined with three-dimensional printing technology. Background technique [0002] With the aging of the population and changes in people's work and lifestyle, there are more and more degenerative disc diseases, especially neck and shoulder pain, low back and leg pain caused by disc herniation are very common, and severe cases often require surgical treatment. Resection is the most commonly used surgical method in spine surgery, but there has been no ideal repair and reconstruction method after disc resection. With the rapid development of tissue engineering technology, intervertebral disc tissue engineering has brought the possibility of permanent repair of intervertebral disc defects after surgery. For this reason, artificial intervertebral disc repair materials are the direct...

Claims

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Application Information

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IPC IPC(8): A61L27/18A61L27/36A61L27/50B33Y10/00B33Y50/02B33Y70/00B33Y80/00
CPCA61L27/18A61L27/3604A61L27/3658A61L27/3687A61L27/50B33Y10/00B33Y50/02B33Y70/00B33Y80/00A61L2430/38C08L67/04
Inventor 乔之光孙彬彬戴尅戎刘永佳赵杰郝永强
Owner SHANGHAI NINTH PEOPLES HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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