Method for preparing high-purity N-acetyl-D glucosamine

A glucosamine, high-purity technology, applied in the preparation of amino sugars, sugar derivatives, chemical instruments and methods, etc., can solve the problems of inability to achieve low-cost, high-yield and high-purity products, large sewage discharge, and complicated processes. , to achieve the effect of low cost, low production cost and simple process

Inactive Publication Date: 2018-08-10
DAZIRAN BIOLOGICAL GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] N-acetyl-D-glucosamine, English name: N-Acetyl-D-Glucosamine, molecular formula: C 8 h 15 NO 6 , Molecular weight: 221.21, N-acetylglucosamine is a new type of biochemical drug, and it is a unit of various polysaccharides in the body. It can improve digestion and absorption, reduce fat and cholesterol intake, lower blood pressure, regulate blood lipids, and promote ulcer healing. Enhance immunity, improve insulin utilization rate, be beneficial to the prevention and treatment of diabetes, etc. At the same time, it can improve human immunity and liver protection and detoxification. The traditional method of producing N-acetyl-D glucosamine usually uses chitin as the starting material. Hydrolysis reaction to obtain D-glucosamine hydro

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] The preparation method of high-purity N-acetyl-D glucosamine includes the following steps,

[0027] a) Ultrafiltration: Dissolve N-acetyl-D glucosamine in water, configure it as an aqueous solution, and perform ultrafiltration with a ceramic membrane to obtain filtrate and residue; the ceramic membrane is set in the raw material tank, and the pore size of the ceramic membrane It is 50nm, the operating pressure is 0.3MPa, the flow rate of the membrane surface is 1.5m / s, and the permeate flow rate is 30L / h;

[0028] b). Decolorization: Add an appropriate amount of activated carbon to the filtrate prepared in step a), react for 0.4h, and filter through a closed filter to obtain a decolorizing solution and wet activated carbon, and the wet activated carbon is recycled;

[0029] c) Desalination: the decolorizing solution in step b) is desalinated by electrodialysis with an electrodialysis membrane at an operating pressure of 0.3 MPa and an operating time of 20 minutes to obtain a d...

Embodiment 2

[0036] The preparation method of high-purity N-acetyl-D glucosamine includes the following steps,

[0037] a) Ultrafiltration: Dissolve N-acetyl-D glucosamine in water, configure it as an aqueous solution, and perform ultrafiltration with a ceramic membrane to obtain filtrate and residue; the ceramic membrane is set in the raw material tank, and the pore size of the ceramic membrane It is 50nm, the operating pressure is 0.4MPa, the flow rate of the membrane surface is 3m / s, and the permeate flow rate is 30L / h;

[0038] b). Decolorization: Add an appropriate amount of activated carbon to the filtrate prepared in step a), react for 0.5h, and filter through a closed filter to obtain a decolorizing solution and wet activated carbon, and the wet activated carbon is recycled;

[0039] c) Desalination: Desalination of the decolorizing solution described in step b) by electrodialysis with an electrodialysis membrane, with an operating pressure of 0.35 MPa and an operating time of 30 minutes,...

Embodiment 3

[0046] The preparation method of high-purity N-acetyl-D glucosamine includes the following steps,

[0047] a) Ultrafiltration: Dissolve N-acetyl-D glucosamine in water, configure it as an aqueous solution, and perform ultrafiltration with a ceramic membrane to obtain filtrate and residue; the ceramic membrane is set in the raw material tank, and the pore size of the ceramic membrane It is 50nm, the operating pressure is 0.45MPa, the flow rate of the membrane surface is 5m / s, and the permeate flow rate is 30L / h;

[0048] b). Decolorization: Add an appropriate amount of activated carbon to the filtrate prepared in step a), react for 0.6h, and filter through a closed filter to obtain a decolorizing solution and wet activated carbon, and the wet activated carbon is recycled;

[0049] c) Desalination: the decolorizing solution described in step b) is desalinated by electrodialysis with an electrodialysis membrane at an operating pressure of 0.4 MPa and an operating time of 40 minutes to o...

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Abstract

The invention discloses a method for preparing high-purity N-acetyl-D glucosamine. The method comprises the following steps: preparing a solution from N-acetyl-D glucosamine, performing ultrafiltration with a ceramic membrane so as to obtain filtrate, putting a proper amount of activated carbon into the filtrate, filtering by using a sealed filtering machine so as to obtain a decolored liquid, performing electrodialysis desalting on the decolored liquid with an electrodialysis membrane so as to obtain a desalted liquid of which the conductivity is 5-50mu s/cm; performing evaporation concentration on the desalted liquid by using an evaporator so as to obtain a high-purity concentrated liquid; putting the high-purity concentrated liquid into a crystal cylinder, adding an organic solvent, andseparating a crystal so as to obtain N-acetyl-D glucosamine crystal slurry; pouring the crystal slurry into a centrifugal machine, performing solid-liquid separation so as to obtain a high-purity N-acetyl-D glucosamine wet crystal, and drying the wet crystal in a vacuum drying machine, so as to obtain the high-purity N-acetyl-D glucosamine of which the content is greater than or equal to 99.50%.Compared with the prior art, the method is low in cost, high in yield, short in process cycle and high in product purity.

Description

Technical field [0001] The invention relates to the technical field of biomedicine processing, in particular to a method for preparing high-purity N-acetyl-D glucosamine. Background technique [0002] N-acetyl-D glucosamine, English name: N-Acetyl-D-Glucosamine, molecular formula: C 8 h 15 NO 6 , Molecular weight: 221.21, N-acetylglucosamine is a new type of biochemical drug, and it is the unit of a variety of polysaccharides in the organism. It can improve digestion and absorption, reduce the intake of fat and cholesterol, lower blood pressure, regulate blood lipids, and promote ulcer healing. Enhance immunity, improve insulin utilization rate, help the prevention and treatment of diabetes, etc., at the same time, it can improve human immunity and protect liver and detoxify. The traditional method of producing N-acetyl-D glucosamine usually uses chitin as the starting material. The hydrolysis reaction produces D-glucosamine hydrochloride, that is, the β-1.4 glycosidic bond is co...

Claims

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Application Information

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IPC IPC(8): C07H5/06C07H1/06
CPCC07H1/06C07H5/06
Inventor 徐恒德朱安伟张西进朱玉钦刘家印
Owner DAZIRAN BIOLOGICAL GRP CO LTD
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