Anti-infective, safe and efficient hemostatic aerogel and preparation method thereof

An airgel and anti-infection technology, which is applied in the fields of pharmaceutical formulation, application, and medical science, can solve the problems of easy access to blood vessel thrombus, no obvious anti-infection effect, poor effect, etc., and achieve simple production process and good swelling performance , less risk of thrombosis

Active Publication Date: 2018-08-21
GUANGDONG OCEAN UNIVERSITY +1
View PDF4 Cites 9 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among these hemostatic materials, zeolite is an inorganic hemostatic material. Due to its porous structure, it can well absorb wound exudate and promote blood coagulation. Blood vessels cause thrombus; dressings such as fibrin dressings, medical gelatin sponges, chitosan bandages, and calcium alginate fiber pads are hemostatic materials with a single raw material, which have no obvious anti-infection effect, and are especially effective for bleeding on wounds, especially deep wounds or ruptured arteries. bad

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Anti-infective, safe and efficient hemostatic aerogel and preparation method thereof
  • Anti-infective, safe and efficient hemostatic aerogel and preparation method thereof
  • Anti-infective, safe and efficient hemostatic aerogel and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Under infrared light, chitosan hydrochloride powder (molecular weight 60 kDa, degree of deacetylation 90%) and 8-O-acetylshanzhiside methyl ester were mixed at a mass ratio of 6:1, and ground for 25 min to obtain 8- Chitosan grafted with O-acetylshanzhiside methyl ester (DS=46.4%); heated with purified water to dissolve gellan gum (0.8‰, W / V), and added sodium alginate (3%, W / V ) to make gellan gum-sodium alginate mixed hot solution; chitosan powder grafted with 8-O-acetylshanzhiside methyl ester (calculated as chitosanate, 2%, W / V) was evenly Disperse in gellan gum-sodium alginate mixed hot solution, let stand to cool, and form hydrogel in situ; put the hydrogel in an autoclave, CO 2 Supercritical drying to produce airgel.

Embodiment 2

[0042] Under infrared light, chitosan acetate powder (molecular weight 50 kDa, degree of deacetylation 100%) and 8-O-acetylshanzhiside methyl ester were mixed at a mass ratio of 7:1, and ground for 20 min to obtain 8- Chitosan grafted with O-acetylshanzhiside methyl ester (DS=53.7%); heated with purified water to dissolve gellan gum (1.0‰, W / V), and added sodium alginate (5%, W / V ) to make gellan gum-sodium alginate mixed hot solution; chitosan powder grafted with 8-O-acetylshanzhiside methyl ester (calculated as chitosanate, 2.5%, W / V) was evenly Disperse in gellan gum-sodium alginate mixed hot solution, let stand to cool, and form hydrogel in situ; put the hydrogel in an autoclave, CO 2 Supercritical drying to produce airgel.

Embodiment 3

[0044] Under infrared light, chitosan lactate powder (molecular weight 80 kDa, degree of deacetylation 95%) and 8-O-acetylshanzhiside methyl ester were mixed at a mass ratio of 5:1, and ground for 30 min to obtain 8- Chitosan grafted with O-acetylshanzhiside methyl ester (DS=41.2%); heated with purified water to dissolve gellan gum (1.2‰, W / V), and added sodium alginate (4%, W / V ) to make gellan gum-sodium alginate mixed hot solution; chitosan powder grafted with 8-O-acetylshanzhiside methyl ester (calculated as chitosanate, 3%, W / V) was evenly Disperse in gellan gum-sodium alginate mixed hot solution, let stand to cool, and form hydrogel in situ; put the hydrogel in an autoclave, CO2 Supercritical drying to produce airgel.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
molecular weightaaaaaaaaaa
molecular weightaaaaaaaaaa
Login to view more

Abstract

The invention discloses anti-infective, safe and efficient hemostatic aerogel which is prepared by supercritical drying after hydrogel is prepared from 8-O-acetyl saponin methyl ester-grafted chitosan, sodium alginate, gellan gum and water; the 8-O-acetyl saponin methyl ester-grafted chitosan is prepared by grinding for 20-30 minutes under infrared light after chitosan salt is mixed with 8-O-acetyl shanzhiside methyl ester according to the mass ratio of (5-8):l; the molecular weight of the chitosan salt is 50-100 kDa, and the degree of deacetylation is 90-100 percent; the chitosan salt is at least one of hydrochloride, acetate and lactate. The 8-O-acetyl saponin methyl ester is grafted to the chitosan, the hydrogel is prepared by the coordination of the sodium alginate, the water and the gellan gum, and the aerogel is obtained by supercritical drying; the prepared hemostatic aerogel is good in swelling property, strong in adhesiveness and quick in hemostasis, difficultly enters blood to cause the thrombosis risk, has an anti-infective effect and is particularly suitable for quick hemostasis of severe bleeding such as deep acute trauma and arterial rupture.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, more specifically, to an anti-infection, safe and efficient hemostatic airgel and a preparation method thereof. Background technique [0002] Hemorrhage is the main factor leading to death in wars, natural disasters, and traffic accidents. Efficient hemostasis can effectively reduce mortality, and hemostasis is the first step in wound healing. [0003] At present, the hemostatic materials on the market are mainly zeolite powder, fibrin dressing, medical gelatin sponge, chitosan bandage, calcium alginate fiber pad, etc. Among these hemostatic materials, zeolite is an inorganic hemostatic material. Due to its porous structure, it can well absorb wound exudate and promote blood coagulation. Blood vessels cause thrombus; dressings such as fibrin dressings, pharmaceutical gelatin sponges, chitosan bandages, and calcium alginate fiber pads are hemostatic materials with a single raw mater...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/08A61L24/00
CPCA61L24/0015A61L24/0031A61L24/08A61L2300/232A61L2300/404A61L2300/418A61L2400/04C08L5/04C08L5/08
Inventor 胡章李思东钟庆坤孔松芝程瑜廖铭能黄娜陈日志罗荣琼
Owner GUANGDONG OCEAN UNIVERSITY
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap