A kind of preparation method of modified starch hemostatic microsphere

A starch and modified technology, applied in pharmaceutical formulations, surgery, drug delivery, etc., can solve the problems of virus infection, poor batch stability, poor repeatability, etc. rate effect

Active Publication Date: 2021-03-02
NINGBO BAOTING BIOTECHNOLOGY CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Chitosan is extracted from the shells of marine organisms such as crabs and shrimps. Its quality varies greatly depending on factors such as the location of marine organisms, growth time, and marine species. Its stability between batches is poor, resulting in Hemostatic products prepared mainly from polysaccharides have disadvantages such as unstable properties and poor reproducibility
At the same time, animal-derived materials have potential risks such as immune activation, microbial and viral infection

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Embodiment one: a kind of preparation method of modified starch hemostatic microspheres, comprises the following specific steps:

[0014] (1) Dissolve starch in distilled water, control the mass concentration to 2%, then adjust the acidity and alkalinity with sodium hydroxide solution to make the pH value 8, heat while stirring, and make it paste at a temperature of 80°C Then add succinic anhydride, control the mass ratio of succinic anhydride and starch to be 1:2, and continue to stir for 2 hours, then wash 3 times with distilled water, wash 3 times with absolute ethanol, preliminarily dry after suction filtration, and then It was moved into a vacuum drying oven and dried at a temperature of 30° C. for 20 hours to obtain the solid particles of the first step;

[0015] (2) Dissolve the solid particles in the first step in distilled water, control the mass concentration to 20%, and adjust the pH value to 12, stir at 60°C for 60 minutes to obtain a uniformly mixed solutio...

Embodiment 2

[0018] Embodiment 2: A preparation method of modified starch hemostatic microspheres, comprising the following specific steps:

[0019] (1) Dissolve starch in distilled water, control the mass concentration to 20%, then adjust the acidity and alkalinity with sodium hydroxide solution to make the pH value 12, heat while stirring, and make it paste at a temperature of 50°C Then add succinic anhydride, control the mass ratio of succinic anhydride and starch to 1:20, and continue to stir for 10 hours, then wash 5 times with distilled water, wash 4 times with absolute ethanol, preliminarily dry after suction filtration, and then It was moved into a vacuum drying oven and dried at a temperature of 40° C. for 15 hours to obtain the solid particles of the first step;

[0020] (2) Dissolve the solid particles in the first step in distilled water, control the mass concentration to 10%, adjust the pH value to 10, stir at 45°C for 100 minutes to obtain a uniformly mixed solution, and then...

Embodiment 3

[0023] Embodiment three: a preparation method of modified starch hemostatic microspheres, comprising the following specific steps:

[0024] (1) Dissolve starch in distilled water, control the mass concentration to 10%, then adjust the acidity and alkalinity with sodium hydroxide solution to make the pH value 11, heat while stirring, and make it paste at a temperature of 65°C Then add succinic anhydride, control the mass ratio of succinic anhydride and starch to be 1:12, and continue to stir for 7 hours, then wash 4 times with distilled water, wash 5 times with absolute ethanol, preliminarily dry after suction filtration, and then It is moved into a vacuum drying oven and dried at a temperature of 50° C. for 10 hours to obtain the solid particles of the first step;

[0025] (2) Dissolve the solid particles in the first step in distilled water, control the mass concentration to 3%, adjust the pH value to 8, stir at 30°C for 120 minutes to obtain a uniformly mixed solution, and t...

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PUM

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Abstract

The invention discloses a method for preparing modified starch hemostatic microspheres. The method is characterized in that with starch as a medium material, succinic anhydride modification and chemical crosslinking are conducted on the starch, and the starch is prepared into the microspheres, so that the surface contact area is greatly increased, the method facilitates increasing the liquid absorption rate and speed of the starch, and the stability of the hemostatic microspheres prepared by the method is high; moreover, by utilizing the characteristic that the hemostatic microspheres quicklyabsorb blood and rapidly swell, the blood vessels are quickly and centralizedly blocked, and the effect of quick hemostasis is achieved; since the hemostasis effect of the modified starch hemostatic microspheres is physical, no chemical or pharmaceutical reagent is used in the function process, the modified starch hemostatic microspheres are safe and reliable and have no side effects on the livingbodies, and the modified starch hemostatic microspheres are not only suitable for hemostasis during in-vivo or body-surface bleeding but also suitable for effective hemostasis for severe traumas caused by sudden disasters or life-threatening major bleeding caused by clinically large surgery.

Description

technical field [0001] The invention relates to the preparation of medical hemostatic products, in particular to a preparation method of modified starch hemostatic microspheres. Background technique [0002] Polysaccharide hemostatic products are often used for hemostasis in clinical operations, civilian use, and large-scale trauma caused by wars and natural disasters. The currently marketed polysaccharide hemostatic products are represented by chitosan and related materials. Chitosan is extracted from the shells of marine organisms such as crabs and shrimps. Its quality varies greatly depending on factors such as the location of marine organisms, growth time, and marine species. Its stability between batches is poor, resulting in Polysaccharide-based hemostatic products have some disadvantages such as unstable properties and poor reproducibility. At the same time, animal-derived materials have potential risks such as immune activation, microbial and viral infections. Con...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L24/08A61L24/00
CPCA61L24/001A61L24/08A61L2400/04C08L3/02
Inventor 竺亚斌李赛何斌
Owner NINGBO BAOTING BIOTECHNOLOGY CO LTD
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