Rectification and purification method of abamectin

A technology of abamectin and purification method, applied in chemical instruments and methods, preparation of sugar derivatives, sugar derivatives, etc., can solve problems such as large steam consumption, high energy consumption, long concentration time, etc., and meet production cycle requirements. effect used

Inactive Publication Date: 2018-08-24
QILU PHARMA INNER MONGOLIA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But there are some problems in this process: 1. A refining and purification process takes about 11-13 hours of working hours. In the process of concentrated crystallization, it takes about 6-8 hours to heat up and concentrate the solution in the crystallization tank, accounting for the total time. about 50% of
2. Due to the long concentration time, the amount of steam used in the concentration process is relatively large, and the energy consumption is high

Method used

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  • Rectification and purification method of abamectin
  • Rectification and purification method of abamectin
  • Rectification and purification method of abamectin

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] A method for refining and purifying abamectin, the refining and purifying of the first batch of abamectin is carried out according to the existing conventional method, and the refining and purifying of each batch is carried out in the form of applying mechanically the mother liquor afterwards, comprising steps as follows:

[0031] (1) During the refining and purification of the second batch of avermectins, add the second methanol mother liquor in the first batch of avermectin refining and purification to the crude product of avermectin, and the addition amount of the second batch of methanol mother liquor is avermectin 6.9 times of the weight of the crude product of mycin, then heat up to 70°C for insulation, filter after all the abamectin is dissolved, cool down to 25°C for crystallization of the filtered crystallization solution, and then press filter for 4 hours to carry out the first pass of refining to obtain For the first pass of refined products, the mother liquor...

Embodiment 2

[0038] A kind of refining purification method of Abamectin, with embodiment 1, difference is:

[0039] Step (1) The amount of methanol mother liquor added twice is 7.1 times the weight of the crude product of abamectin, and then the temperature is raised to 72°C for insulation, and the avermectin is completely dissolved and then filtered, and the filtered crystal solution is cooled to 27°C Carry out crystallization, then press filter 6h to carry out the first round of refining,

[0040] Step (2) adds three times of methanol mother liquor in the first batch of abamectin refining and purification to the first batch of fine products and heats up to keep 72°C for insulation, and the addition amount of three times of methanol mother liquor is the weight of abamectin crude product 8.3 times of 8.3 times, after the first time the refined product is dissolved, the temperature is lowered to 27°C for crystallization;

[0041] Step (3) adds new methanol to the second time fine product a...

Embodiment 3

[0045] A kind of refining purification method of Abamectin, with embodiment 1, difference is:

[0046] Step (1) The amount of methanol mother liquor added twice is 7.5 times the weight of the crude product of abamectin, and then the temperature is raised to 75°C for insulation, and the avermectin is completely dissolved and then filtered, and the filtered crystal solution is cooled to 30°C Carry out crystallization, then press filter 4h to carry out the first round of refining,

[0047] Step (2) adds three times of methanol mother liquor in the first batch of abamectin refining and purification to the first batch of fine products and heats up to keep 75°C for insulation, and the addition amount of three times of methanol mother liquor is the weight of abamectin crude product 8.5 times of 8.5 times, the first time after the refined product is dissolved, the temperature is lowered to 30°C for crystallization;

[0048] Step (3) adds new methanol to the second time fine product a...

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Abstract

The invention relates to a rectification and purification method of abamectin. According to the method, mother liquid heating concentration is eliminated in a production process, but mother liquid cyclic use is adopted; by the adoption of mother liquid use, the saturation degree of crystallization can be met without the heating concentration, so that the time for conventional one rectification isshortened by about 5 hours; and furthermore, the use amount of steam consumed by concentration is reduced. In addition, the content of a rectified product is not reduced; and the aims of shortening the working time, saving energy and reducing the consumption are fulfilled.

Description

Technical field: [0001] The invention relates to a method for refining and purifying abamectin, and belongs to the technical field of biological pesticide refining. Background technique: [0002] Abamectin is a low-toxic, high-efficiency, high-selection, green, environmental-friendly, bio-sourced insecticide. It completely solves the problem of environmental pollution caused by traditional pesticides. , "Ninth Five-Year Plan" and "Eleventh Five-Year Plan" key research projects. With the popularity and promotion of Abamectin and its downstream products in recent years, it has not only driven the vigorous development of my country's agriculture and animal husbandry, but also promoted the transformation of agricultural and animal husbandry production to a green and harmless direction. Abamectin, one of the most effective insecticides in the world, has a domestic consumption of about 2,500 tons and has become a leading product among pesticides and insecticides. [0003] In the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H17/08C07H1/06
CPCC07H1/06C07H17/08
Inventor 王敏秋王翔居亚东
Owner QILU PHARMA INNER MONGOLIA
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