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Guided tissue regeneration membrane and preparation method thereof

A technology for guiding tissue regeneration and products, applied in the field of guiding tissue regeneration membrane and its preparation, can solve the problems of harsh preparation conditions, long preparation period and high energy consumption, and achieve the effect of simple and easy preparation method

Active Publication Date: 2018-08-31
苏州迈锐再生医学科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In the prior art, the preparation method of guided tissue regeneration film mainly uses pigskin as raw material and is prepared by freeze-drying method. However, this preparation method has the following disadvantages: the use of toxic organic solvents; harsh preparation conditions, Need to create extremely low temperature, high energy consumption; at the same time, the preparation cycle is long and the efficiency is low

Method used

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  • Guided tissue regeneration membrane and preparation method thereof
  • Guided tissue regeneration membrane and preparation method thereof
  • Guided tissue regeneration membrane and preparation method thereof

Examples

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Effect test

Embodiment 1

[0042] A method for preparing a guided tissue regeneration film, comprising the following steps:

[0043] (1) Polylactide-glycolide copolymer-silica (PLGA-SiO 2 , its GA / LA molar ratio is 70:30, molecular weight is 25, SiO 2 The mass fraction is 25%, the equivalent diameter is 500nm) and polycaprolactone-tricalcium phosphate (PCL-β-TCP, the molecular weight is 80,000, the β-TCP mass fraction is 10%, the equivalent diameter is 200nm) by heat The polylactide glycolide / polycaprolactone composite sheet made by pressing method, the schematic diagram of the composite sheet is as figure 1 As shown (first layer is polylactide-co-glycolide-silica);

[0044] The flakes are then placed in the reactor;

[0045] (2) Put the reaction kettle into a constant temperature water bath at 80°C, and replace the gas in the kettle with carbon dioxide;

[0046] (3) Pressurize the high-pressure vessel to 20MPa. Saturate the flakes in the reactor at 80°C and 20MPa for 1 hour;

[0047] (4) Fast pre...

Embodiment 2

[0050] A method for preparing a guided tissue regeneration film, comprising the following steps:

[0051] (1) Polycaprolactone-biological glass (PCL-BG, molecular weight is 80,000, BG mass fraction is 30%, equivalent diameter is 500nm) and polycaprolactone (PCL, molecular weight is 80,000) by hot pressing Polylactide glycolide / polycaprolactone composite sheet material is prepared by the method, and the schematic diagram of the composite sheet material is as figure 1 shown (the first layer is polycaprolactone-bioglass);

[0052] The flakes are then placed in the reactor;

[0053] (2) Put the reaction kettle into a constant temperature water bath at 60°C, and replace the gas in the kettle with carbon dioxide;

[0054] (3) Pressurize the high-pressure vessel to 15MPa. Under the conditions of 70°C and 15MPa, saturate the flakes in the reactor for 1.5h;

[0055] (4) Fast pressure release, the pressure release rate is 60MPa / s, and the guided tissue regeneration membrane can be o...

Embodiment 3

[0058] A method for preparing a guided tissue regeneration film, comprising the following steps:

[0059] (1) Polycaprolactone-biological glass (PCL-BG, molecular weight is 80,000, BG mass fraction is 6%, equivalent diameter is 500nm) and polycaprolactone (PCL, molecular weight is 80,000) by hot pressing Polylactide glycolide / polycaprolactone composite sheet material is prepared by the method, and the schematic diagram of the composite sheet material is as figure 1 shown (the first layer is polycaprolactone-bioglass);

[0060] The flakes are then placed in the reactor;

[0061] (2) Put the reaction kettle into a constant temperature water bath at 60°C, and replace the gas in the kettle with carbon dioxide;

[0062] (3) Pressurize the high-pressure vessel to 15MPa. Under the conditions of 70°C and 15MPa, saturate the flakes in the reactor for 1.5h;

[0063] (4) Fast pressure release, the pressure release rate is 60MPa / s, and the guided tissue regeneration membrane can be ob...

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Abstract

The invention discloses a preparation method of a guided tissue regeneration membrane, wherein the method comprises the following steps: (1) selecting at least two samples, wherein at least one of thesamples is an inorganic polymer composite material; forming by a forming technology, obtaining a primary product stacked with at least two layers, and then placing the primary product in a high pressure vessel; (2) replacing gas in the high pressure vessel with supercritical fluid; (3) pressurizing the high pressure vessel, and making the primary product saturated in a high-temperature and high-pressure supercritical fluid atmosphere; and (4) rapidly relieving the pressure, and thus obtaining the guided tissue regeneration membrane. A supercritical fluid is used as a physical foaming agent, amembrane material with a multi-layer distributed pore structure is controllably prepared by adjusting a layered distribution structure of inorganic fillers in medical biodegradable polymers, and themedical biodegradable polymer membrane material with layered distribution of macropores and small pores is obtained, has the multifunctionality of well guiding tissue regeneration and rail guiding ofa defect area and preventing invasion of other tissues and can meet the requirements of guided regeneration.

Description

technical field [0001] The invention relates to a membrane for guiding tissue regeneration and a preparation method thereof. Background technique [0002] Guided Tissue Regeneration (Guided Tissue Regeneration, GTR) is a surgical method to place a physical barrier to selectively separate different periodontal tissues, prevent gingival epithelium and gingival connective tissue from growing to the root surface, create space, and induce periodontal tissue. Periodontal ligament cells with tissue regeneration potential move coronally, grow and differentiate, realize regeneration of periodontal ligament, alveolar bone, and cementum, and form new periodontal attachments. Since Nyman S applied the principle of guided tissue regeneration (Guided tissue regeneration GTR) to the physiological regeneration of new periodontal attachments, more and more scholars have devoted themselves to applying the principle of GTR to clinical practice. However, due to the differences in the selection...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/12A61L31/14
CPCA61L31/127A61L31/128A61L31/146A61L31/148C08L67/04
Inventor 奚桢浩赵玲宋超波陆尔奕崔立宇岑莲张嘉鹏张洪波李双韩宇晴
Owner 苏州迈锐再生医学科技有限公司