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Drug-loaded guided tissue regeneration (GTR) membrane and preparation method thereof

A technique for guiding tissue regeneration and drugs, applied in the field of drug-loaded guided tissue regeneration membranes and its preparation, can solve the problems of membrane material cracking, increased membrane material brittleness, unfavorable bone conduction regeneration, etc., and achieve the effect of simple and easy preparation method

Active Publication Date: 2020-05-22
苏州高哲斯环境新材料有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this method has the following two problems: (1) It must use inorganic fillers to change the polymer matrix in supercritical CO 2 Thermal and rheological behavior in the environment, thereby affecting supercritical CO 2 Diffusion behavior in the melt to obtain a guided tissue regeneration film suitable for tooth restoration, while the introduction of inorganic fillers increases the brittleness of the film material and easily leads to cracking of the film material
(2) The guided tissue regeneration membrane obtained by this preparation method still stays in the state of membrane material, lacks osteoconductivity and osteoinductivity, and is not conducive to guided regeneration of bone

Method used

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  • Drug-loaded guided tissue regeneration (GTR) membrane and preparation method thereof
  • Drug-loaded guided tissue regeneration (GTR) membrane and preparation method thereof
  • Drug-loaded guided tissue regeneration (GTR) membrane and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0044] A method for preparing a drug-loaded guided tissue regeneration membrane, comprising the following steps:

[0045] (1) Polylactide-glycolide copolymer-silicon dioxide (PLGA-SiO 2 , its GA / LA molar ratio is 70:30, molecular weight is 25, SiO 2 The mass fraction is 25%, and the equivalent diameter is 500nm) and BMP-2 loaded polycaprolactone-tricalcium phosphate (MBP-2 / PCL-β-TCP, the PCL molecular weight is 80,000, and the β-TCP mass fraction is 10%, the equivalent diameter is 200nm) to make polylactide glycolide / polycaprolactone composite sheet material by hot pressing method, the schematic diagram of composite sheet material is as figure 1 As shown (the first layer is polylactide-co-glycolide-silica);

[0046] The flakes are then placed in the reactor;

[0047] (2) Put the reaction kettle into a constant temperature water bath at 80°C, and replace the gas in the kettle with carbon dioxide;

[0048] (3) Pressurize the high-pressure vessel to 20MPa. Saturate the flake...

Embodiment 2

[0052] A method for preparing a drug-loaded guided tissue regeneration membrane, comprising the following steps:

[0053] (1) IGF-1-loaded polycaprolactone-biological glass (penicillin / PCL-BG, molecular weight is 80,000, BG mass fraction is 30%, equivalent diameter is 500nm) and polycaprolactone (PCL, molecular weight 80,000) to obtain the polycaprolactone-bioglass / polycaprolactone composite sheet material loaded by IGF-1 by hot pressing, the schematic diagram of the composite sheet material is as figure 1 As shown (the first layer is polycaprolactone-bioglass loaded with IGF-1);

[0054] The flakes are then placed in the reactor;

[0055] (2) Put the reaction kettle into a 60°C constant temperature water bath, and replace the gas in the kettle with carbon dioxide;

[0056] (3) Pressurize the high-pressure vessel to 15MPa. Under the conditions of 80°C and 15MPa, saturate the flakes in the reactor for 1.5h;

[0057] (4) Fast pressure release, the pressure release rate is 60...

Embodiment 3

[0060] A method for preparing a drug-loaded guided tissue regeneration membrane, comprising the following steps:

[0061] (1) Polycaprolactone-biological glass (PCL-BG, molecular weight is 80,000, BG mass fraction is 6%, equivalent diameter is 500nm) and MBP-7 loaded polycaprolactone (BMP-7 / PCL , with a molecular weight of 80,000) to obtain polycaprolactone-bioglass / MBP-7-loaded polycaprolactone composite flakes by hot pressing, the schematic diagram of the composite flakes is as follows figure 1 Shown (the first layer is polycaprolactone-bioglass);

[0062] The flakes are then placed in the reactor;

[0063] (2) Put the reaction kettle into a 60°C constant temperature water bath, and replace the gas in the kettle with carbon dioxide;

[0064] (3) Pressurize the high-pressure vessel to 15MPa. Under the conditions of 80°C and 15MPa, saturate the flakes in the reactor for 1.5h;

[0065] (4) Fast pressure release, the pressure release rate is 60MPa / s, and the guided tissue re...

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Abstract

The invention discloses a preparation method of a drug-loaded guided tissue regeneration (GTR) membrane. The preparation method comprises the following steps: (1) selecting at least two samples, carrying out molding by a molding technology to obtain at least two layers of stacked primary products, and then, placing the primary products in a high-pressure vessel, wherein at least one of the two samples is a compound of a drug-loaded macromolecular polymer and an inorganic material or the drug-loaded macromolecular polymer; (2) replacing gas in the high-pressure vessel with a supercritical fluid; (3) boosting the high-pressure vessel; and (4) rapidly relieving the pressure. By controlling the drug loading types, content and aggregation state of high polymer materials loaded on different layers of the membrane, a medical biodegradable polymeric membrane material with layered distribution of large and small pores is prepared, and the material can have multiple functions of well guiding tissue regeneration of defective areas and stopping invasion of other tissue, and can meet the guided regeneration requirement to achieve the tissue repair purpose.

Description

technical field [0001] The invention relates to a drug-loaded guided tissue regeneration film for tooth restoration and a preparation method thereof. Background technique [0002] Periodontal disease is one of the common oral diseases in humans. In the early stage of the disease, the structure of the periodontal supporting tissue is destroyed. As the disease progresses, the periodontal structure is gradually lost, resulting in tooth loss. For this disease, guided tissue regeneration has emerged. Guided Tissue Regeneration (Guided Tissue Regeneration, GTR) is a surgical method to place a physical barrier to selectively separate different periodontal tissues, preventing the growth of gingival epithelium and gingival connective tissue to the root surface, creating space, and inducing periodontal tissue. Periodontal ligament cells with tissue regeneration potential move coronally, grow and differentiate, realize regeneration of periodontal ligament, alveolar bone, and cementum,...

Claims

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Application Information

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IPC IPC(8): A61L31/12A61L31/14A61L31/16
CPCA61L31/123A61L31/124A61L31/125A61L31/148A61L31/16A61L31/146A61L2300/252A61L2300/414A61L2300/412
Inventor 奚桢浩宋超波韩宇晴张嘉鹏岑莲陆尔奕崔立宇
Owner 苏州高哲斯环境新材料有限公司
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