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Guided tissue regeneration film and preparation method thereof

A technology for guiding tissue regeneration and products, applied in the field of guiding tissue regeneration film and its preparation, can solve the problems of harsh preparation conditions, long preparation cycle, low efficiency, etc., and achieve the effect of simple and easy preparation method

Active Publication Date: 2021-02-26
苏州迈锐再生医学科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In the prior art, the preparation method of guided tissue regeneration film mainly uses pigskin as raw material and is prepared by freeze-drying method. However, this preparation method has the following disadvantages: the use of toxic organic solvents; harsh preparation conditions, Need to create extremely low temperature, high energy consumption; at the same time, the preparation cycle is long and the efficiency is low

Method used

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  • Guided tissue regeneration film and preparation method thereof
  • Guided tissue regeneration film and preparation method thereof
  • Guided tissue regeneration film and preparation method thereof

Examples

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Effect test

Embodiment 1

[0042] A method for preparing a guided tissue regeneration film, comprising the following steps:

[0043] (1) Polylactide-glycolide copolymer-silica (PLGA-SiO 2 , its GA / LA molar ratio is 70:30, molecular weight is 25, SiO 2 The mass fraction is 25%, the equivalent diameter is 500nm) and polycaprolactone-tricalcium phosphate (PCL-β-TCP, the molecular weight is 80,000, the β-TCP mass fraction is 10%, the equivalent diameter is 200nm) by heat The polylactide glycolide / polycaprolactone composite sheet made by pressing method, the schematic diagram of the composite sheet is as figure 1 As shown (first layer is polylactide-co-glycolide-silica);

[0044] The flakes are then placed in the reactor;

[0045] (2) Put the reaction kettle into a constant temperature water bath at 80°C, and replace the gas in the kettle with carbon dioxide;

[0046] (3) Pressurize the high-pressure vessel to 20MPa. Saturate the flakes in the reactor at 80°C and 20MPa for 1 hour;

[0047] (4) Fast pre...

Embodiment 2

[0050] A method for preparing a guided tissue regeneration film, comprising the following steps:

[0051] (1) Polycaprolactone-biological glass (PCL-BG, molecular weight is 80,000, BG mass fraction is 30%, equivalent diameter is 500nm) and polycaprolactone (PCL, molecular weight is 80,000) by hot pressing Polylactide glycolide / polycaprolactone composite sheet material is prepared by the method, and the schematic diagram of the composite sheet material is as figure 1 shown (the first layer is polycaprolactone-bioglass);

[0052] The flakes are then placed in the reactor;

[0053] (2) Put the reaction kettle into a constant temperature water bath at 60°C, and replace the gas in the kettle with carbon dioxide;

[0054] (3) Pressurize the high-pressure vessel to 15MPa. Under the conditions of 70°C and 15MPa, saturate the flakes in the reactor for 1.5h;

[0055] (4) Fast pressure release, the pressure release rate is 60MPa / s, and the guided tissue regeneration membrane can be o...

Embodiment 3

[0058] A method for preparing a guided tissue regeneration film, comprising the following steps:

[0059] (1) Polycaprolactone-biological glass (PCL-BG, molecular weight is 80,000, BG mass fraction is 6%, equivalent diameter is 500nm) and polycaprolactone (PCL, molecular weight is 80,000) by hot pressing Polylactide glycolide / polycaprolactone composite sheet material is prepared by the method, and the schematic diagram of the composite sheet material is as figure 1 shown (the first layer is polycaprolactone-bioglass);

[0060] The flakes are then placed in the reactor;

[0061] (2) Put the reaction kettle into a constant temperature water bath at 60°C, and replace the gas in the kettle with carbon dioxide;

[0062] (3) Pressurize the high-pressure vessel to 15MPa. Under the conditions of 70°C and 15MPa, saturate the flakes in the reactor for 1.5h;

[0063] (4) Fast pressure release, the pressure release rate is 60MPa / s, and the guided tissue regeneration membrane can be ob...

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Abstract

The invention discloses a method for preparing a membrane for guiding tissue regeneration, which comprises the following steps: (1) selecting at least two kinds of samples, at least one of which is an inorganic polymer composite material, and shaping it by molding technology to obtain at least two layers of laminated The primary product is then placed in a high-pressure container; (2) supercritical fluid is used to replace the gas in the high-pressure container; (3) the high-pressure container is pressurized so that the primary product is produced in a high-temperature and high-pressure supercritical fluid atmosphere Saturation; (4) Quickly release the pressure to obtain a guided tissue regeneration membrane. The present invention uses supercritical fluid as a physical foaming agent, realizes the controllable preparation of membrane materials with multi-level distribution of pore structure by deploying inorganic fillers in the layered distribution structure of medical biodegradable polymers, and prepares large-pore and small-pore layers The distributed medical biodegradable polymer membrane material can well guide the tissue regeneration in the defect area and the multifunctionality of guiding the track and preventing the invasion of other tissues can meet the requirements of guiding regeneration.

Description

technical field [0001] The invention relates to a membrane for guiding tissue regeneration and a preparation method thereof. Background technique [0002] Guided Tissue Regeneration (Guided Tissue Regeneration, GTR) is a surgical method to place a physical barrier to selectively separate different periodontal tissues, prevent gingival epithelium and gingival connective tissue from growing to the root surface, create space, and induce periodontal tissue. Periodontal ligament cells with tissue regeneration potential move coronally, grow and differentiate, realize regeneration of periodontal ligament, alveolar bone, and cementum, and form new periodontal attachments. Since Nyman S applied the principle of guided tissue regeneration (Guided tissue regeneration GTR) to the physiological regeneration of new periodontal attachments, more and more scholars have devoted themselves to applying the principle of GTR to clinical practice. However, due to the differences in the selection...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L31/12A61L31/14
CPCA61L31/127A61L31/128A61L31/146A61L31/148C08L67/04
Inventor 奚桢浩赵玲宋超波陆尔奕崔立宇岑莲张嘉鹏张洪波李双韩宇晴
Owner 苏州迈锐再生医学科技有限公司