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Double-layer guided tissue regeneration membrane material and preparation method thereof

A technology that guides tissue regeneration and membrane materials. It is used in pharmaceutical formulations, medical science, surgery, etc. It can solve the problems of GTR treatment failure, fast degradation, and poor mechanical properties, achieve excellent histocompatibility, and avoid inflammation. The effect of high reaction and product stability

Active Publication Date: 2021-08-27
EAST CHINA UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the collagen membrane also has disadvantages such as poor mechanical properties and too fast degradation, which may cause early epithelial cells to subside and cause the risk of GTR treatment failure.
Collagen membrane is the most widely used clinically Mainly rely on imports, expensive

Method used

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  • Double-layer guided tissue regeneration membrane material and preparation method thereof
  • Double-layer guided tissue regeneration membrane material and preparation method thereof
  • Double-layer guided tissue regeneration membrane material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] A method for preparing a double-layer guided tissue regeneration membrane material, comprising the steps of:

[0054] (1) Preparation of loose layer

[0055] Polycaprolactone (PCL) with a molecular weight of 200kDa is molded by hot-pressing technology, and the hot-pressed PCL is put into a height-limited mold, and then put into a polytetrafluoroethylene chamber of a foaming kettle to obtain a primary product;

[0056] placing the primary product in a high-pressure vessel and displacing the gas in said high-pressure vessel with a supercritical fluid;

[0057] The high-pressure container is placed in a constant temperature tank, and the temperature is raised to a set foaming temperature of 50° C. to keep the primary product in the high-pressure container for 10 minutes;

[0058] Pressurize the high-pressure container, increase the pressure of the foaming system to the set foaming pressure of 15 MPa, and saturate the sample for 2 hours under this condition to ensure that ...

Embodiment 2

[0067] A method for preparing a double-layer guided tissue regeneration membrane material, comprising the steps of:

[0068] (1) Preparation of loose layer

[0069] Polyglycolide (PGA) with a molecular weight of 200kDa is molded by hot-pressing technology, the hot-pressed PGA is put into a height-limited mold, and then put into a polytetrafluoroethylene chamber of a foaming kettle to obtain a primary product ;

[0070] placing the primary product in a high-pressure vessel and displacing the gas in said high-pressure vessel with a supercritical fluid;

[0071] The high-pressure container is placed in a constant temperature tank, and the temperature is raised to a set foaming temperature of 50° C. to keep the primary product in the high-pressure container for 10 minutes;

[0072] Pressurize the high-pressure container, increase the pressure of the foaming system to the set foaming pressure of 15 MPa, and saturate the sample for 2 hours under this condition to ensure that the C...

Embodiment 3

[0081] A method for preparing a double-layer guided tissue regeneration membrane material, comprising the steps of:

[0082] (1) Preparation of loose layer

[0083] The PCL pellets with a molecular weight of 10kDa are formed by hot-pressing technology, and the hot-pressed PCL is put into a height-limited mold, and then put into a polytetrafluoroethylene chamber of a foaming kettle to obtain a primary product;

[0084] placing the primary product in a high-pressure vessel and displacing the gas in said high-pressure vessel with a supercritical fluid;

[0085] The high-pressure container is placed in a constant temperature tank, and the temperature is raised to a set foaming temperature of 50° C. to keep the primary product in the high-pressure container for 10 minutes;

[0086] Pressurize the high-pressure container, increase the pressure of the foaming system to the set foaming pressure of 15 MPa, and saturate the sample for 2 hours under this condition to ensure that the CO ...

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Abstract

The invention discloses a double-layer guided tissue regeneration membrane material and a preparation method thereof. The double-layer guided tissue regeneration membrane material comprises a compact layer facing periosteum and a loose layer facing a bone defect area. The preparation method comprises the following steps that the compact layer is composed of I-type collagen; the loose layer is prepared from polyester through supercritical CO2 foaming, a polyester foaming material is evenly coated with a collagen solution, then drying treatment is conducted, and the double-layer guided tissue regeneration membrane is obtained. By uniformly arranging the compact layer on the loose layer, the guided tissue regeneration membrane with excellent tissue compatibility and good mechanical performance is prepared, and the guided tissue regeneration membrane has relatively high inductivity to fibroblasts, has a hemostatic function, has a more appropriate degradation rate, is high in product stability and can effectively avoid inflammatory response; and further clinical popularization and application of the regeneration operation can be guided, and the success rate of the periodontal operation is improved.

Description

technical field [0001] The invention relates to the technical field of medical materials, in particular to a double-layer guiding tissue regeneration membrane material and a preparation method thereof. Background technique [0002] In the field of stomatology, periodontal disease, root apex lesions, trauma and other reasons will cause periodontal tissue defects, and insufficient bone mass in implant denture restoration will cause defects in tooth support. Guided tissue regeneration (Guided TIssueRegeneratIon, GTR) has the advantages of less trauma, convenient operation, and good bone augmentation effect. It is currently recognized as a dental implant repair technique. The core of guided tissue regeneration is to use the membrane material as a barrier in periodontal surgery to prevent soft tissue from growing into the bone defect area; at the same time, the membrane material can also selectively guide the periodontal ligament cells with regenerative potential to proliferate p...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/12A61L31/06A61L31/04A61L31/14A61L31/16
CPCA61L31/06A61L31/044A61L31/14A61L31/146A61L31/148A61L31/16A61L2400/04C08L67/04
Inventor 何湘奚桢浩赵玲王杰罗蕴涵韩宇晴张冰雁吴鑫
Owner EAST CHINA UNIV OF SCI & TECH