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A kind of double-layer guided tissue regeneration membrane material and its preparation method

A technology for guiding tissue regeneration and membrane material, which can be used in pharmaceutical formulations, surgery, drug delivery, etc. It can solve the problems of GTR treatment failure, poor mechanical properties, and excessive degradation speed, and achieve excellent tissue compatibility and product stability. The effect of high sex and avoiding inflammatory reaction

Active Publication Date: 2022-06-14
EAST CHINA UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the collagen membrane also has disadvantages such as poor mechanical properties and too fast degradation, which may cause early epithelial cells to subside and cause the risk of GTR treatment failure.
Collagen membrane is the most widely used clinically Mainly rely on imports, expensive

Method used

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  • A kind of double-layer guided tissue regeneration membrane material and its preparation method
  • A kind of double-layer guided tissue regeneration membrane material and its preparation method
  • A kind of double-layer guided tissue regeneration membrane material and its preparation method

Examples

Experimental program
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Effect test

Embodiment 1

[0053] A preparation method of a double-layer guided tissue regeneration membrane material, comprising the following steps:

[0054] (1) Preparation of loose layer

[0055] The polycaprolactone (PCL) with a molecular weight of 200kDa is formed by hot pressing technology, the PCL after hot pressing is placed in a height-limiting mold, and then placed in the polytetrafluoroethylene cell of the foaming kettle to obtain the primary product;

[0056] placing the primary product in a high pressure vessel and replacing the gas in the high pressure vessel with a supercritical fluid;

[0057] The high-pressure container is placed in a constant temperature tank, and the temperature is raised to a set foaming temperature of 50°C, and the primary product in the high-pressure container is kept warm for 10 minutes;

[0058] Pressurize the high-pressure vessel, increase the pressure of the foaming system to the set foaming pressure of 15MPa, and saturate the sample under this condition for ...

Embodiment 2

[0067] A preparation method of a double-layer guided tissue regeneration membrane material, comprising the following steps:

[0068] (1) Preparation of loose layer

[0069] The polyglycolide (PGA) with a molecular weight of 200kDa is formed by hot pressing technology, the PGA after hot pressing is placed in a height-limiting mold, and then placed in the polytetrafluoroethylene cell of the foaming kettle to obtain a primary product ;

[0070] placing the primary product in a high pressure vessel and replacing the gas in the high pressure vessel with a supercritical fluid;

[0071] The high-pressure container is placed in a constant temperature tank, and the temperature is raised to a set foaming temperature of 50°C, and the primary product in the high-pressure container is kept warm for 10 minutes;

[0072] Pressurize the high-pressure vessel, increase the pressure of the foaming system to the set foaming pressure of 15MPa, and saturate the sample under this condition for 2h ...

Embodiment 3

[0081] A preparation method of a double-layer guided tissue regeneration membrane material, comprising the following steps:

[0082] (1) Preparation of loose layer

[0083] The PCL pellets with a molecular weight of 10kDa are formed by hot pressing technology, and the hot pressed PCL is placed in a height-limiting mold, and then placed in the PTFE cell of the foaming kettle to obtain a primary product;

[0084] placing the primary product in a high pressure vessel and replacing the gas in the high pressure vessel with a supercritical fluid;

[0085] The high-pressure container is placed in a constant temperature tank, and the temperature is raised to a set foaming temperature of 50°C, and the primary product in the high-pressure container is kept warm for 10 minutes;

[0086] Pressurize the high-pressure vessel, increase the pressure of the foaming system to the set foaming pressure of 15MPa, and saturate the sample under this condition for 2h to ensure that CO 2 fully satur...

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Abstract

The invention discloses a double-layer guided tissue regeneration membrane material and a preparation method thereof. The double-layer regeneration membrane includes a dense layer facing the periosteum and a loose layer facing the bone defect area; the preparation method is as follows: the dense layer is composed of type I collagen; the loose layer The layer is made of polyester foamed by supercritical CO2, and the collagen solution is evenly coated on the polyester foam material, and then dried to obtain a double-layer guided tissue regeneration film; the present invention evenly arranges the dense layer On the loose layer, prepare a guided tissue regeneration membrane with excellent tissue compatibility and good mechanical properties, which has a high induction to fibroblasts, has hemostatic function, and has a more suitable degradation rate, and the product is stable It is highly resistant and can effectively avoid inflammatory reactions; it is helpful to guide the further clinical application of regenerative surgery and improve the success rate of periodontal surgery.

Description

technical field [0001] The invention relates to the technical field of medical materials, in particular to a double-layer guided tissue regeneration membrane material and a preparation method thereof. Background technique [0002] In the field of stomatology, periodontal disease, root apical disease, trauma and other reasons can cause periodontal tissue defects, and reasons such as insufficient bone mass in implant denture restoration can cause defects that prevent tooth support. Guided tissue regeneration (GuIded TIssueRegeneratIon, GTR) has the advantages of less trauma, convenient operation, and good bone augmentation effect. The core of guided tissue regeneration is to use the membrane material as a barrier in periodontal surgery to prevent soft tissue from growing into the bone defect area; at the same time, the membrane material can also selectively guide the periodontal ligament cells with regeneration potential to preferentially proliferate to the root surface. This...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L31/12A61L31/06A61L31/04A61L31/14A61L31/16
CPCA61L31/06A61L31/044A61L31/14A61L31/146A61L31/148A61L31/16A61L2400/04C08L67/04
Inventor 何湘奚桢浩赵玲王杰罗蕴涵韩宇晴张冰雁吴鑫
Owner EAST CHINA UNIV OF SCI & TECH