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Method for detecting impurity 5-methoxytryptamine in melatonin bulk drug by means of thin layer chromatography

A methoxytryptamine and thin-layer chromatography technology, which is applied in the field of thin-layer chromatography analysis and detection of impurity 5-methoxytryptamine, can solve the problem of unsatisfactory analysis results of thin-layer chromatography, inaccurate analysis methods, obsolete, etc. problem, to achieve the effect of easy color development, low cost and convenient operation

Active Publication Date: 2018-09-14
罗田县新普生药业有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

For a long time, due to the unsatisfactory analysis results of thin-layer chromatography, many people think that it is an old, outdated and inaccurate analysis method, which should be replaced by more accurate and reliable other chromatography methods, such as high performance liquid chromatography. Phase / Gas Chromatography

Method used

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  • Method for detecting impurity 5-methoxytryptamine in melatonin bulk drug by means of thin layer chromatography
  • Method for detecting impurity 5-methoxytryptamine in melatonin bulk drug by means of thin layer chromatography
  • Method for detecting impurity 5-methoxytryptamine in melatonin bulk drug by means of thin layer chromatography

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Embodiment

[0023] (1) Preparation of different concentration gradient melatonin sample solutions

[0024] Melatonin raw materials were from Hubei Jinsai Pharmaceutical Co., Ltd. Utilize this melatonin crude drug sample and methylene chloride to prepare standard solution A with a concentration of 10 g / L, take an appropriate amount of standard solution A, and dilute it 100 times and 1000 times respectively to obtain sample solution B and sample solution C in sequence.

[0025] (2) Preparation of different concentration gradient impurity control solutions

[0026] Utilize 5-methoxytryptamine standard substance and dichloromethane to prepare 10g / L impurity control solution I. Take an appropriate amount of impurity control solution I and dilute it 100 times and 1000 times respectively to obtain impurity control solution II and impurity control solution III in sequence.

[0027] (3) Take the thin-layer plate, draw a straight line about 1 cm from the bottom of the thin-layer plate, and then t...

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Abstract

The invention relates to a method for detecting impurity 5-methoxytryptamine in melatonin bulk drug by means of thin layer chromatography. The method can be used for simply and rapidly determining whether the concentration of the related impurity in the melatonin bulk drug extends the standard or not. The method has the advantages of being time-saving, low in detection cost, convenient to operate,simple in equipment, easy in developing, visual and reliable in result, and the like.

Description

technical field [0001] The invention relates to the technical field of pharmacy, in particular to a thin-layer chromatographic analysis and detection method for impurity 5-methoxytryptamine in melatonin bulk medicine. Background technique [0002] Melatonin, also known as Melatonin, melatonin, pineal gland, is a white or off-white crystalline powder, slightly soluble in water, soluble in acetone, ethyl acetate and methanol. Since the scientist Lerner discovered and obtained Melatonin from the pineal gland of the bovine brain in 1959, there have been more and more studies on melatonin in recent years. Through continuous exploration, people have gradually discovered that melatonin has various functions such as regulating circadian rhythm, improving sleep quality, anti-oxidation, anti-inflammation, inhibiting the growth of tumor cells, enhancing human immune function, improving memory and delaying aging. Although the research on this aspect has just started, the progress is ve...

Claims

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Application Information

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IPC IPC(8): G01N30/90G01N30/94
CPCG01N30/90G01N30/94
Inventor 祝宏李丽王雯洁李洁潘晓涵
Owner 罗田县新普生药业有限公司
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