Barium meal with pneumatosis shadow radiography function and preparation method thereof

An imaging and functional technology, applied in the field of medical materials, can solve the problems of cumbersome steps, physical and psychological burden of patients, and inconvenient use, and achieve the effects of improving imaging quality, promoting gastrointestinal motility, and preventing moisture failure.

Inactive Publication Date: 2018-09-18

CHANGSHU INTEREST SHARING INFORMATION TECH CO LTD

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AI-Extracted Technical Summary

Problems solved by technology

[0005] However, in this invention, the stomach needs to be dilated before eating the barium meal, and the barium meal can only be swallowed after the stomach expands to a certain extent. There are many types of medicines,...

Abstract

The invention relates to the technical field of medical materials and in particular to a barium meal with a pneumatosis shadow radiography function and a preparation method thereof. A formula of a medical cleaning agent comprises the following raw materials in parts by weight: aerogenesis powder, agar, a chelator, sodium alginate, gelatin, starch, barium sulfate, absolute ethyl alcohol, and a suitable amount of deionized water. The prepared barium meal adopts a layered particle design. Usual barium meal fluid is converted to the solid barium meal, and a sugar coating on the outermost layer canprevent the barium meal from being affected with damp so as to lose efficacy; the secondary outer layer is prepared from the aerogenesis powder, the agar and the gelatin, after the barium meal is swallowed, a lot of CO2 can be generated in a stomach, so that the stomach is swelled; the next layer is a barium meal layer, the barium sulfate forms a radiography layer in the stomach, and the residualaerogenesis powder also provides the pneumatosis shadow radiography, so the radiography quality is improved; and the final layer is a core of the chelator, the chelator containing a lot of cellulosecan promote gastrointestinal motility, and the barium meal is accelerated to be excreted to the outside of a body.

Application Domain

X-ray constrast preparations

Technology Topic

MotilityChemistry +17

Examples

Experimental program(4)

Example Embodiment

[0021] Example 1:

[0022] A barium meal with air contrast imaging function. The medical cleaning agent is formulated with the following raw materials in weight fraction: 30 parts of gas generating powder, 40 parts of agar, 15 parts of excretion promoter, 4 parts of sodium alginate, 5 parts of gelatin, starch 4 parts, 40 parts barium sulfate, 6 parts anhydrous ethanol, and an appropriate amount of deionized water.

[0023] Preferably, the excretion promoting agent includes 8 parts of cellulose, 1 part of maltodextrin, 2 parts of citrus fiber, and 1 part of oat fiber.

[0024] Preferably, the preparation method of the medical cleaning agent includes the following steps:

[0025] a. Weigh each component of appropriate quality as required, and put each solid raw material into a ball mill for ball milling;

[0026] b. Pour the excretion accelerator, 1/3 of the agar, sodium alginate and absolute ethanol into deionized water 3 times the solid component, continue to stir, heat in a water bath at 50°C, and concentrate, and the resulting component is cooled Then it forms a solid sol-like component, denoted as component a;

[0027] c. Pour 1/2 gas generating powder, barium sulfate, 1/3 agar and starch into deionized water, keep stirring, heat in a water bath at 60℃, and concentrate, and when the liquid becomes a viscous solution, Coated on the outside of component a, wait for it to cool and coat it on its surface again, until all coating is completed, the obtained component is recorded as component b;

[0028] d. Pour 1/2 gas-producing powder, 1/3 agar and gelatin into deionized water at 85°C for stirring and concentration. When the liquid becomes a viscous solution, coat it on the outside of component b, and let it cool Then, syrup is used to coat the outside with sugar coating to obtain the finished barium meal.

[0029] Preferably, the particle size of the powder obtained in step a after ball milling is 400 mesh.

[0030] Preferably, the mass of the deionized water in the steps b, c, d is 5 times that of the solid components.

[0031] Preferably, the original liquid components in steps b, c, d are concentrated to 15% of the original volume.

Example Embodiment

[0032] Example 2:

[0033] A barium meal with air contrast imaging function. The medical cleaning agent is formulated with the following raw materials in weight fraction: 40 parts of gas generating powder, 50 parts of agar, 12 parts of excretion accelerator, 2 parts of sodium alginate, 10 parts of gelatin, starch 2 parts, 50 parts of barium sulfate, 4 parts of anhydrous ethanol, proper amount of deionized water.

[0034] Preferably, the excretion promoting agent includes 7 parts of cellulose, 2 parts of maltodextrin, 1 part of citrus fiber, and 2 parts of oat fiber.

[0035] Preferably, the preparation method of the medical cleaning agent includes the following steps:

[0036] a. Weigh each component of appropriate quality as required, and put each solid raw material into a ball mill for ball milling;

[0037] b. Pour the excretion accelerator, 1/3 of agar, sodium alginate and absolute ethanol into deionized water 5 times the solid component, continue to stir, heat in a water bath at 40°C, and concentrate, and the resulting component is cooled Then it forms a solid sol-like component, denoted as component a;

[0038] c. Pour 1/2 gas-producing powder, barium sulfate, 1/3 agar and starch into deionized water, continue to stir, heat in a water bath at 70℃, and concentrate, and when the liquid becomes a viscous solution, Coated on the outside of component a, wait for it to cool and coat it on its surface again, until all coating is completed, the obtained component is recorded as component b;

[0039] d. Pour 1/2 gas-producing powder, 1/3 agar and gelatin into deionized water at 80°C for stirring and concentrating. When the liquid becomes a viscous solution, coat it on the outside of component b, and let it cool Then, syrup is used to coat the outside with sugar coating to obtain the finished barium meal.

[0040] Preferably, the particle size of the powder obtained in step a after ball milling is 450 mesh.

[0041] Preferably, the mass of the deionized water in the steps b, c, d is 7 times that of the solid components.

[0042] Preferably, the original liquid components in steps b, c, d are concentrated to 25% of the original volume.

Example Embodiment

[0043] Example 3:

[0044] A barium meal with air contrast imaging function. The medical cleaning agent is formulated with the following raw materials in weight fraction: 50 parts of gas generating powder, 20 parts of agar, 13 parts of excretion promoter, 3 parts of sodium alginate, 6 parts of gelatin, starch 6 parts, 30 parts of barium sulfate, 4 parts of absolute ethanol, and appropriate amount of deionized water.

[0045] Preferably, the excretion promoting agent includes 10 parts of cellulose, 1 part of maltodextrin, 2 parts of citrus fiber, and 2 parts of oat fiber.

[0046] Preferably, the preparation method of the medical cleaning agent includes the following steps:

[0047] a. Weigh each component of appropriate quality as required, and put each solid raw material into a ball mill for ball milling;

[0048] b. Pour the excretion accelerator, 1/3 of agar, sodium alginate and absolute ethanol into deionized water 7 times the solid component, continue to stir, heat in a water bath at 70°C, and concentrate, and the resulting component is cooled Then it forms a solid sol-like component, denoted as component a;

[0049] c. Pour 1/2 gas generating powder, barium sulfate, 1/3 agar and starch into deionized water, continue to stir, heat in a water bath at 50℃, and concentrate, when the liquid becomes a viscous solution Coated on the outside of component a, wait for it to cool and coat it on its surface again, until all coating is completed, the obtained component is recorded as component b;

[0050] d. Pour 1/2 gas-producing powder, 1/3 agar and gelatin into deionized water at 90°C for agitation and concentration. When the liquid becomes a viscous solution, coat it on the outside of component b and let it cool Then, syrup is used to coat the outside with sugar coating to obtain the finished barium meal.

[0051] Preferably, the particle size of the powder obtained in step a after ball milling is 500 mesh.

[0052] Preferably, the mass of the deionized water in the steps b, c, d is 10 times that of the solid components.

[0053] Preferably, the original liquid components in steps b, c, d are concentrated to 30% of the original volume.

PUM

Property	Measurement	Unit
Particle size	350.0 ~ 500.0	mesh

Description & Claims & Application Information

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Barium meal with pneumatosis shadow radiography function and preparation method thereof

AI-Extracted Technical Summary

Problems solved by technology

Abstract

Examples

Example Embodiment

Example Embodiment

Example Embodiment

PUM

Description & Claims & Application Information

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