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A kind of preparation method of Jingangteng soft capsule

A technology of soft capsules and diamonds, which is applied in the direction of microcapsules, capsule delivery, and pharmaceutical formulations. It can solve problems such as drying difficulties, achieve good drug quality stability, ensure standard compliance, and increase stability.

Active Publication Date: 2021-05-18
SICHUAN KELUN PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The purpose of the present invention is to overcome the drying difficulties existing in the preparation process of Jingangteng soft capsules in the prior art, as well as the problem of product stability and consistency risk control, and to provide a new preparation method of Jingangteng soft capsules

Method used

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  • A kind of preparation method of Jingangteng soft capsule
  • A kind of preparation method of Jingangteng soft capsule
  • A kind of preparation method of Jingangteng soft capsule

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Preparation of King Kongtaw Extract Extract Powder

[0046] Such as figure 1 As shown in the process flow, take King Kong Fuji original medicinal material, wash, slice, add 10 times the weight of pure water to decoct and extract twice, combine the extracts, and discard the filter residue. The combined decoctions were concentrated under reduced pressure to 1g decoction / 1g raw medicinal materials, added ethanol, precipitated with alcohol, filtered, concentrated under reduced pressure, and then vacuum-dried at 60°C for 4.5 hours to obtain King Kongteng extract powder (about 380mg~ 440mg; under the premise of meeting the preparation process, 1 part of soybean oil can dilute 1.3 parts of vacuum-dried extract powder and 1 part of spray-dried extract powder), and the water content of the extract powder is ≤1.0%. After passing the inspection, it will be stored for later use.

Embodiment 2

[0051] Preparation of Jingangteng Soft Capsules

[0052] Such as figure 2 As shown in the technological process, get 40.0 grams of raw materials of King Kongteng extract powder obtained in Example 1, 38.5 grams of soybean oil, 2.0 grams of beeswax, and 1.0 grams of glycine. After the beeswax is chopped, add about 1 / 3 of soybean oil and mix, heat and dissolve Completely, then add the remaining soybean oil, 40.0 grams of King Kongteng extract powder, 3.5 grams of sorbitol, and 1.0 grams of glycine, and grind for 40 minutes to obtain the soft capsule content raw materials, which are set aside. Take 100.0 grams of gelatin, 40.0 grams of glycerin, 90.0 grams of purified water, 10.0 grams of sorbitol, 1.0 grams of glycine, etc. for soft capsules, mix them, heat to 75°C, dissolve completely, vacuum degas and dehydrate, and obtain uniform soft capsule skin raw materials , kept at 60°C for later use. The soft capsule skin of insulation and soft capsule content raw material are mad...

Embodiment 3

[0054] Preparation of Jingangteng Soft Capsules

[0055] Such as figure 2 As shown in the technical process, get 40 grams of diamond vine extract powder raw materials obtained in Example 1, 38.5 grams of soybean oil, 2 grams of beeswax, 3.5 grams of spray lactose, and 1.0 grams of glycine. After chopping the beeswax, add about 1 / 3 Soybean oil is mixed, heated and dissolved completely, then the remaining soybean oil, King Kongteng extract powder, hydrophilic spray lactose, and glycine are added, and ground for 40 minutes, which is the raw material of the soft capsule content and set aside. Take 100.0 grams of gelatin, 40.0 grams of glycerin, 90.0 grams of purified water, 10.0 grams of sorbitol, 1.0 grams of glycine, etc. for soft capsules, mix them, heat to 75 ° C, complete dissolution, vacuum degassing, and dehydration to obtain a uniform soft capsule skin Raw materials, keep warm at 60°C and set aside for later use. The soft capsule skin raw material of heat preservation...

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Abstract

The invention discloses a preparation method of jingangteng soft capsules, which comprises the following steps: (1) washing the raw medicinal material of jingangteng, extracting it by water extraction and alcohol precipitation, and drying the extract in vacuum to obtain the extract powder of jingangteng. The temperature of the vacuum-dried material is controlled at 0°C to 70°C; (2) Mix the extract powder prepared in step 1 and the soft capsule content raw materials including soybean oil, lactose, and beeswax evenly, and emulsify under high pressure homogeneously to obtain a soft capsule Contents; (3) Mix the soft capsule skin raw materials including gelatin, glycerin, water, and antioxidant, heat up and dissolve, and vacuum degas and dehydrate to obtain the capsule skin glue for preparing soft capsules; 2. Mix the contents of the soft capsule and the above-mentioned soft capsule glue to make a soft capsule, then dry and pack to obtain the finished product. The technical extract of the invention adopts the low-temperature continuous vacuum drying technology; at the same time, the contents of the soft capsule and the capsule skin components are precisely controlled, the medicine is stable, meets the preparation standard, and the clinical medicine is safe and reliable.

Description

technical field [0001] The invention relates to a method for preparing a soft capsule, in particular to a method for preparing a jingangteng soft capsule, which belongs to the technical field of pharmaceutical engineering. Background technique [0002] King Kongteng (also known as Smilax bá葜qiā) has the effects of dispelling wind, promoting blood circulation and detoxification. King Kong Teng Soft Capsule is a soft capsule made of King Kong Teng extract, which has the functions of clearing heat and detoxifying, reducing swelling and dissipating stagnation, anti-inflammatory and analgesic, anti-infection, anti-tumor, and promoting blood circulation. Jingangteng Soft Capsule has a good inhibitory effect on acute and subacute gynecological inflammation, and is the first choice recommended by the Chinese Society of Traditional Chinese Medicine and the Gynecological Branch of the Chinese Medical Association for the diagnosis and treatment of gynecological diseases. [0003] Gyne...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/90A61K36/896A61K9/48A61K47/26A61K47/18A61P15/00
CPCA61K9/4808A61K9/4825A61K9/5015A61K36/896A61K36/90A61K2236/331A61K2236/39A61K2236/51A61K2236/53
Inventor 黎荣袁成刚陈彪江靖刘思川葛均友万阳浴
Owner SICHUAN KELUN PHARMA CO LTD
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