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Lipidosome microbubble metal-loaded-ICG self-assembly composite system

A self-assembly, liposome technology, applied in the field of biomedical materials and nanomedicine, can solve the problems of short metabolic cycle, limited application, limited ROS production, etc., and achieve the effect of effective transportation and improved acoustic power effect.

Active Publication Date: 2018-09-28
XIAMEN UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, the short metabolic cycle of ICG itself and the limited production of ROS under ultrasonic irradiation also limit its application in SDT.

Method used

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  • Lipidosome microbubble metal-loaded-ICG self-assembly composite system
  • Lipidosome microbubble metal-loaded-ICG self-assembly composite system
  • Lipidosome microbubble metal-loaded-ICG self-assembly composite system

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Embodiment 1

[0043] This embodiment is a preparation example, and it selects metal ion Fe 3+ For the preparation example.

[0044] (1) Use Isothermal titration calorimetry (ITC) to detect the best Fe 3+ : ICG molar ratio: first prepare the buffer solution. Add 70.5mL CH to 167mL Hepes buffer (10mM, pH=6.8) 3 OH,11.5mLCHCl 3 and 1mL n-hexane and let it stand for 24h; the Fe 3+ (Ferric chloride) and ICG are prepared as 0.05mM and 1mM solutions respectively with the buffers prepared above; drop ICG into the metal ion solution at 20°C, and finally know that the ratio of metal ions to ICG is 2 ICG molecules with 1 Fe 3+ Matching.

[0045] (2) Find the best dispersing solvent: configure different volume ratios of methanol: water solvents (such as 10:1, 5:1, 3:1, 2:1, 1:1, 1:2, 1:3, 1 :5,1:10); Dissolve 1mg ICG in 5ml of different methanol:water solvents, and drop Fe in the optimal ratio obtained in 1) 3+ The molar amount is mixed with the same kind of methanol: the metal ion solution (5m...

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Abstract

The invention discloses a lipidosome microbubble metal-loaded-ICG self-assembly composite system which has a multimode imaging / sonodynamic therapy (SDT) function. The system shows sonodynamic performance better than pure ICG molecules and has sonodynamic therapeutic effects of fixed-point explosion of lipidosome microbubbles, drug fixed-point release and increase of animal disease models of tumor,infection and atherosis. The invention further relates to sonodynamic therapy guided by metal ion / ICG@Microbubbless ultrasonic imaging, fluorescent imaging and photoacoustic imaging. The system is simple to prepare, cheap in price and remarkable in therapeutic effect.

Description

technical field [0001] The present invention relates to a liposome microbubble-loaded metal ion-ICG self-assembly system, and also relates to its preparation method and the liposome microbubble used in subcutaneous tumors, in situ tumors, atherosclerosis and other animal disease models. The application of diagnosis and treatment integration in dynamic therapy belongs to the field of biomedical materials and nanomedicine. Background technique [0002] Malignant tumors and cardiovascular diseases are one of the biggest killers threatening human life and health in the world in the 21st century. Effective diagnosis and treatment of them are major challenges in the current biomedical research field. Clinically, traditional treatment methods mainly include surgery, radiotherapy and chemotherapy. However, traditional therapy has high risks, lack of specificity, will destroy the immune system, and the emergence of chemotherapy drug resistance has greatly limited its application. P...

Claims

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Application Information

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IPC IPC(8): A61K41/00A61K9/127A61K47/28A61K49/00A61K49/22A61P35/00
CPCA61K9/1271A61K41/0033A61K47/28A61K49/0002A61K49/0034A61K49/0084A61K49/223A61K49/227A61P35/00
Inventor 刘刚林惠荣楚成超李霜庞鑫
Owner XIAMEN UNIV
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