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A prothrombin time detection method and device

A prothrombin time and detection method technology, applied in the field of prothrombin time PT detection, can solve the problems of inaccurate test results, prothrombin time detection accuracy and reliability, and inaccurate measurement results, etc., to achieve a good guarantee , reduce erroneous results, and improve accuracy

Active Publication Date: 2021-02-09
HELIXGEN GUANGZHOU
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Problems solved by technology

However, the detected reaction signal may have noise due to various interferences, which will affect the detection accuracy and reliability of the prothrombin time, resulting in inaccurate test results; in addition, in the above detection process, usually by collecting Detecting a single characteristic point on the current to calculate the prothrombin time, in the case of a single characteristic point may have errors, it will also cause inaccurate measurement results

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  • A prothrombin time detection method and device
  • A prothrombin time detection method and device
  • A prothrombin time detection method and device

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Embodiment 1

[0068] figure 1 It is a schematic flow chart of a prothrombin time PT detection method provided by the embodiment of the present invention, referring to figure 1 As shown, the method includes:

[0069] 101. The blood sample undergoes coagulation reaction under the action of the dry reagent, and the oxidizable substances released thereby are oxidized by the DC voltage applied to the working electrode to generate an oxidation current. The oxidation current detected during this process can be called the original reaction current.

[0070] 102. Smoothing the current-time curve of the oxidation current obtained in step 101 as a function of time, to generate a processed current-time curve;

[0071] Optionally, the smoothing process is as follows:

[0072] The current-time curve is sampled according to a preset time interval to obtain n points; the embodiment of the present invention does not limit the specific preset time interval.

[0073] When processing the jth point on the ...

Embodiment 2

[0095] figure 2 It is a schematic structural diagram of a prothrombin time PT detection device provided in an embodiment of the present invention. refer to figure 2 As shown, the detector includes: a reaction current detection module 21 , a data processing module 22 , a user interface module 23 and a central control module 24 .

[0096] Specifically, the reaction current detection module 21 is used to detect the oxidation current, which is generated when the blood sample undergoes coagulation reaction under the action of the dry reagent, and the released oxidizable substances are oxidized by the DC voltage applied to the working electrode. The specific operation steps are as follows: apply a DC voltage between the working electrode and the reference electrode, and simultaneously detect the oxidation current generated on the working electrode. Here, the DC voltage is provided by a DC voltage source circuit, generally tens of millivolts to hundreds of millivolts, such as 100...

Embodiment 3

[0118] An embodiment of the present invention provides a prothrombin time PT detection device, the detection device includes a memory and a processor connected to the memory, the memory is used to store a set of program codes, and the processor calls the codes stored in the memory to execute the following operate:

[0119] Smoothing the current-time curve of the oxidation current over time to generate the processed current-time curve; wherein, the oxidation current is the coagulation reaction of the blood sample under the action of the dry reagent, and the oxidizable substances released thereby are It is produced by the oxidation of DC voltage applied to the working electrode;

[0120] Obtain multiple feature points on the processed current-time curve;

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Abstract

A prothrombin time (PT) detection method and device. The prothrombin time detection method comprises: a blood sample undergoing a coagulation reaction under the effect of a dry reagent, and generating an oxidation current (step 101); forming a current-time curve of the change in oxidation current against time (step 102); acquiring multiple feature points of a processed current-time curve (step 103); calculating and outputting the prothrombin time according the multiple feature points (step 104). A smoothing process is performed on the detected oxidation current to increase a signal-to-noise ratio of the oxidation current, so as to avoid the influence of current noise on the accuracy and reliability of prothrombin time detection, enhancing the accuracy of test results. Moreover, multiple feature points of a processed current-time curve are acquired, and prothrombin time is calculated based on the multiple feature points, thus further enhancing the accuracy of test results.

Description

technical field [0001] The invention relates to the medical field, in particular to a prothrombin time PT detection method and device. Background technique [0002] Many patients with cardiovascular diseases (such as venous thromboembolic disease, atrial fibrillation thromboembolism, valvular disease, artificial valve replacement and intracardiac thrombosis, etc.) need long-term anticoagulant therapy with warfarin. But too much warfarin can cause protracted bleeding, and too little can interfere with its antithromboembolic effects, which can lead to serious consequences such as a heart attack or stroke. Therefore, the coagulation function of patients taking warfarin must be monitored regularly. The monitoring of the existing anticoagulant therapy is generally realized by detecting the prothrombin time (Prothrombin Time, PT) of the patient. [0003] There are many methods for the detection of PT, including optical method, electrical impedance method, magnetic bead method, e...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N27/26
CPCG01N27/26
Inventor 赵天贤张围张仑曾庆
Owner HELIXGEN GUANGZHOU
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