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406 results about "Venous thromboembolic disease" patented technology
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When a blood clot breaks loose and travels in the blood, this is called a venous thromboembolism (VTE). The abbreviation DVT/PE refers to a VTE where a deep vein thrombosis (DVT) has moved to the lungs (PE or pulmonary embolism).
Amidino derivatives and drugs containing the same as the active ingredient
InactiveUS6358960B1BiocideGroup 5/15 element organic compoundsExtracorporeal circulationDisseminated coagulopathy
The novel amidino derivatives of the formula (I):wherein all the symbols are as in specification defined;have an inhibitory activity of a blood coagulation factor VIIa and are useful for treatment and / or prevention of several angiopathy caused by enhancing a coagulation activity, such as disseminated intravascular coagulation, coronary thrombosis, cerebral infarction, cerebral embolism, transient ischemic attack, cerebrovascular disorders, pulmonary vascular diseases, deep venous thrombosis, peripheral arterial obstruction, thrombosis after artificial vascular transplantation and artificial valve transplantation, post-operative thrombosis, reobstruction and restenosis after coronary artery bypass operation, reobstruction and restenosis after PTCA or PTCR, thrombosis by extracorporeal circulation and procoagulative diseases such as glomerlonephriitis.
Owner:ONO PHARMA CO LTD
Method and apparatus for treating wound using negative pressure therapy
InactiveUS7896823B2Easy to returnReduce edemaBlood stagnation preventionPneumatic massageVacuum assistedThrombus
Devices that employ external compression stocking-type garments in the treatment of edema, chronic wounds, deep venous thrombosis prevention or claudication all share a number of significant limitations. These include the frequent need for custom fitting to assure an appropriate fit, vigilant maintenance to assure a continued “good fit,” limited compliance with proper use by patients and difficulty of application. There is a large body of evidence demonstrating that patients often decline to wear the compressive stockings as prescribed or in the form that would be most beneficial because they find these devices to be difficult to put on and take off.Building on the limitations of existing therapies, and distilled lessons learned from the field of prosthetics and wound healing, the present invention employs vacuum-assisted negative pressure to provide compression and help pump fluid from the tissues of affected limbs. The device is embodied in the form of a flexible stocking-like garment that will utilize a pumping mechanism to generate negative pressure around the limb and thus create vacuum compression that will mobilize fluid in a limb and increase venous return to the heart. Through the use of a circumferential wrap, the present invention provides a major advance in both the distribution of vacuum and the securing of the device over the limb.
Owner:THERANOVA LLC
Methods and compositions for the diagnosis of venous thromboembolic disease
InactiveUS20070269836A1Improve discriminationMicrobiological testing/measurementDisease diagnosisDiseaseVein
The present invention relates to methods and compositions for symptom-based differential diagnosis, prognosis, and determination of treatment regimens in subjects. In particular, the invention relates to methods and compositions selected to rule in or out venous thromboembolic disease, pulmonary embolism, and / or deep vein thrombosis, and for risk stratification in such conditions.
Owner:BIOSITE INC
Diamine derivatives
A compound represented by the general formula (1):Q1-Q2-T0-N(R1)-Q3-N(R2)-T1-Q4 (1)wherein R1 and R2 are hydrogen atoms or the like; Q1 is a saturated or unsaturated, 5- or 6-membered cyclic hydrocarbon group which may be substituted, or the like; Q2 is a single bond or the like; Q3 is a groupin which Q5 is an alkylene group having 1 to 8 carbon atoms, or the like; and T0 and T1 are carbonyl groups or the like; a salt thereof, a solvate thereof, or an N-oxide thereof.The compound is useful as an agent for preventing and / or treating cerebral infarction, cerebral embolism, myocardial infarction, angina pectoris, pulmonary infarction, pulmonary embolism, Buerger's disease, deep venous thrombosis, disseminated intravascular coagulation syndrome, thrombus formation after valve or joint replacement, thrombus formation and reocclusion after angioplasty, systemic inflammatory response syndrome (SIRS), multiple organ dysfunction syndrome (MODS), thrombus formation during extracorporeal circulation, or blood clotting upon blood drawing.
Owner:DAIICHI SANKYO CO LTD
Locally-plugged thrombus scaler
The invention provides a locally-plugged thrombus scaler, which comprises a core tube, a sleeve, a first saccule, a second saccule and a thrombus scraping skein, wherein the sleeve is sleeved outside the core tube in a movable way; the first saccule is connected to the head end of the core tube; the second saccule is sleeved outside an inner tube of the sleeve; and the thrombus scraping skein is sleeved outside the core tube in a movable way and is arranged in front of the sleeve. By the locally-plugged thrombus scaler, two saccules are expanded simultaneously to plug thrombus deposition positions on veins and form a section of closed space, and thrombus is crushed and scraped by rotating the thrombus scraping skein in the closed space. The locally-plugged thrombus scaler can scrape thrombus completely, prevent vein inner membranes from being injured, discharge the thrombus from human bodies completely and prevent crushed small thrombus blocks from remaining in the human bodies, is suitable for scraping venous thrombosis of limbs of the human bodies and is particularly suitable for scraping the thrombus at the deep positions of femoral veins of the human bodies by using a percutaneous microtrauma surgical technology.
Owner:UNIV OF SHANGHAI FOR SCI & TECH
Use of a mast cell activation or degranulation blocking agent in the manufacture of a medicament for the treatment of cerebral ischemia
InactiveUS20060276455A1Influence permeabilityIncrease the number ofBiocideAnimal repellantsCardiorespiratory arrestSubarachnoid hemorrhage
The invention concerns the use of a mast cell activation- or degranulation-blocking agent in the manufacture of a medicament for the treatment of cerebral ischemia. The invention also relates to treatment of patients suffering from acute ischemic stroke, acute hemorrhagic stroke, subarachnoid hemorrhage, cerebral venous thrombosis or global cerebral ischemia associated with cardiac arrest. Further, the invention provides compositions of contrast media or similar exogenous media, which are intended for use in diagnostic or therapeutic applications for introduction into the intravascular, intrathecal or the intracranial space, comprising a mast cell degranulation-blocking and / or mast cell activation-blocking agent.
Owner:LICENTIA OY
Diamine derivatives
InactiveUS20050245565A1Preventing and treating thrombosisBiocideNervous disorderExtracorporeal circulationDisease
A compound represented by the general formula (1): Q1-Q2-T0-N(R1)-Q3-N(R2) -T1-Q4 (1) wherein R1 and R2 are hydrogen atoms or the like; Q1 is a saturated or unsaturated, 5- or 6-membered cyclic hydrocarbon group which may be substituted, or the like; Q2 is a single bond or the like; Q3 is a group in which Q5 is an alkylene group having 1 to 8 carbon atoms, or the like; and T0 and T1 are carbonyl groups or the like; a salt thereof, a solvate thereof, or an N-oxide thereof. The compound is useful as an agent for preventing and / or treating cerebral infarction, cerebral embolism, myocardial infarction, angina pectoris, pulmonary infarction, pulmonary embolism, Buerger's disease, deep venous thrombosis, disseminated intravascular coagulation syndrome, thrombus formation after valve or joint replacement, thrombus formation and reocclusion after angioplasty, systemic inflammatory response syndrome (SIRS), multiple organ dysfunction syndrome (MODS), thrombus formation during extracorporeal circulation, or blood clotting upon blood drawing.
Owner:DAIICHI SANKYO CO LTD
Genetic polymorphisms associated with venous thrombosis, methods of detection and uses thereof
ActiveUS8071291B2Reduce riskIncreased riskOrganic active ingredientsPeptide/protein ingredientsThrombusReagent
Owner:CELERA CORPORATION
Diamine derivatives
ActiveUS7576135B2Enhanced inhibitory effectPreventing and treating thrombosisBiocideOrganic chemistryExtracorporeal circulationDisease
A compound represented by formula (1):Q1-Q2-T0-N(R1)-Q3-N(R2)-T1-Q4 (1)[wherein R1 and R2 are hydrogen atoms or the like; Q1 is a saturated or unsaturated, 5- or 6-membered cyclic hydrocarbon group which may be substituted, or the like; Q2 is a single bond or the like; Q3 represents the following group:(wherein Q5 is an alkylene group having 1 to 8 carbon atoms, or the like); and T0 and T1 are carbonyl groups or the like], a salt thereof, a solvate thereof, or an N-oxide thereof.The compound is useful as an agent for preventing and / or treating cerebral infarction, cerebral embolism, myocardial infarction, angina pectoris, pulmonary infarction, pulmonary embolism, Buerger's disease, deep venous thrombosis, disseminated intravascular coagulation syndrome, thrombus formation after artificial valve or joint replacement, thrombus formation and reocclusion after angioplasty, systemic inflammatory response syndrome (SIRS), multiple organ dysfunction syndrome (MODS), thrombus formation during extracorporeal circulation, or blood clotting upon blood drawing.
Owner:DAIICHI SANKYO CO LTD
Exercise instrument for preventing deep venous thrombosis of lower limbs
InactiveCN110051514AImprove applicabilitySpeed up the flowDevices for pressing relfex pointsSuction-kneading massageDrive wheelThrombus
The invention discloses an exercise instrument for preventing deep venous thrombosis of lower limbs. The exercise instrument for preventing deep venous thrombosis of lower limbs comprises a casing, the upper end of the casing is provided with two sliding grooves with corresponding positions, a measuring side wall of the casing is respectively provided with a first device chamber and a sliding plugchamber, the side wall of the casing is fixedly connected to a driving motor, one end of an output shaft of the driving motor located in the first device chamber is fixedly connected to a first bevelgear, the inner wall of the first device chamber is rotatably connected to a driving wheel, the side wall of the driving wheel is coaxially fixedly connected to a second bevel gear meshed with the first bevel gear, the upper end of the casing is provided with a first groove communicated with the first device chamber, and the inner walls of the two sliding grooves are rotatably connected to parallelly-arranged first reciprocating lead screws. The exercise instrument for preventing deep venous thrombosis of lower limbs can massage the foot sole and instep to achieve a function of stimulating limb nerves, an ankle joint is protected from stiffness deformation, the foot drop is effectively prevented, and the rehabilitation of a patient is promoted.
Owner:黄伟
Stockings for prevention and treatment of deep venous thrombosis incorporating ultrasound
A device which combines pneumatic compression therapy and ultrasound based therapy for the prevention and treatment of thrombosis. Ultrasound transducers (11) are placed in specially designed pockets (12) in stockings (23) or leggings (25). This allows for convenient use of ultrasound therapy. Pneumatic compression is also carried out by air bladders (14) which are placed in leggings. The overall result is an easy to use device which should produce significantly better results in the prevention and treatment of thrombosis, ultimately reducing patient morbidity and mortality.
Owner:ALEXANDER ROMAN OSHMYANSKY
Positive pressure chamber for extremities
InactiveUS20100042027A1Eliminate needObserve intuitivelyPneumatic massageVibration massageVeinExtremity swelling
The present invention provides a positive pressure chamber for treating extremities, which is used for treating extremity swelling or edema, rehabilitation, prophylaxis for deep venous thrombosis, relieving extremity pain, improvement of extremity skin, and the like.
Owner:NAGOYA UNIVERSITY
Synthesis, activity and application for 1, 1-dihydroxymethyl-tetrahydro-beta-carboline-3-formyl-GRGDV
ActiveCN109134606AInhibitory activityPeptide/protein ingredientsPeptide preparation methodsP-selectinMedicine
The invention discloses a (3S) -1, 1-Dihydroxymethyl-Tetrahydro-Beta-Carboline-3-Formyl-Gly-Arg-Gly-Asp-Val, discloses a preparation method thereof, discloses the anti-arterial thrombosis activity, discloses the anti-venous thrombosis activity, discloses the activity of inhibiting the GPIIb / IIIa expression, and discloses the activity of inhibiting the P-selectin expressionin vivo. Therefore, the invention discloses the application in preparing anti-arterial thrombosis medicine, the application in preparing the anti-venous thrombosis medicine, the application in preparing the GPIIb / IIIa antagonist and the application in preparing P-selectin antagonist. The formulas are shown in the decription.
Owner:CAPITAL UNIVERSITY OF MEDICAL SCIENCES
Traditional Chinese medicinal composition for promoting blood circulation and removing obstructions in channels
The invention relates to a traditional Chinese medicinal composition for promoting the blood circulation and removing obstructions in channels. The traditional Chinese medicinal composition is prepared from the following raw materials, by weight, 15 parts of salvia miltiorrhiza, 12 parts of leech, 9 parts of Ligusticum wallichii, 9 parts of lumbricus, 10 parts of Radix Paeoniae Rubra, 5 parts of centipede, 6 parts of safflower, 4 parts of scorpion, 3 parts of Millettia dielsiana, 5 parts of Malayan pangolin, 8 parts of Chinese angelica, 6 parts of Radix Astragali, 5 parts of Achyranthes bidentata, 5 parts of rhizome of Whiteback Greenbrier, 4 parts of haw, and 6 parts of dandelion. The traditional Chinese medicinal composition of the invention is clinically applied to one hundred and twenty cases of venous thrombosis, and results show that: the traditional Chinese medicinal composition allows one-hundred and fourteen cases to be cured, is effective to five cases and is ineffective to zero case, so the cure rate is 95%, the effective rate is 4%, and the total effective rate is 100%. The traditional Chinese medicinal composition of the invention, which has the advantages of simple preparation, simultaneous treatment of principal and subordinate symptoms, no side effect and low price, has a wide application prospect.
Owner:江苏华鑫源医药有限公司
Synthesis, activity and application for 1, 1 dimethylol-tetrahydro-beta-carboline-3-formyl-GYISGK
ActiveCN109134605AInhibitory activityPeptide/protein ingredientsPeptide preparation methodsP-selectinMedicine
The invention discloses a (3S) -1, 1-Dihydroxymethyl-Tetrahydro-Beta-Carboline-3-Formyl-Gly-Tyr-Ile-Gly-Ser-Lys, discloses a preparation method thereof, discloses the anti-arterial thrombosis activity, discloses the anti-venous thrombosis activity, discloses the activity of inhibiting the GPIIb / IIIa expression, and discloses the activity of inhibiting the P-selectin expression in vivo. Therefore,the invention discloses the application in preparing anti-arterial thrombosis medicine, the application in preparing the anti-venous thrombosis medicine, the application in preparing the GPIIb / IIIa antagonist and the application in preparing P-selectin antagonist. The formulas are shown in the decription.
Owner:CAPITAL UNIVERSITY OF MEDICAL SCIENCES
Vibrational therapy assembly for treating and preventing the onset of deep venous thrombosis
Owner:AMERICAN MEDICAL INNOVATIONS LLC
Growth arrest specific gene 6 peptides, antibodies, compositions, methods and uses
The present invention provides novel proteins and peptides from the receptor binding region of human Growth Arrest Specific Gene 6 (Gas6) and antibodies, including specified portions or variants, specific for at least one such Gas6 peptide or fragment thereof. The aforesaid peptides can be used to generate human, primate, rodent, mammalian, chimeric, humanized and / or CDR-grafted anti-Gas6 antibodies. The invention also provides for the nucleic acids encoding such peptides and anti-Gas6 antibodies, complementary nucleic acids, vectors, host cells, and methods of making and using thereof, including therapeutic formulations, administration and devices. Fifteen novel peptide sequences from the Gas6 G domain that are implicated in Gas6 interactions with its receptors are identified, isolated, and synthesized so as to allow generation of anti-Gas6 antibodies. The peptide sequences include three ESTs that encompass regions predicted to contribute to receptor binding or that can raise anti-Gas6 antibodies. This invention provides for such antibodies to be used in modulating or treating at least one Gas6-related disease in a cell, tissue, organ, animal, or patient. Such diseases may include, but are not limited to, thromboembolic disease, ischemic disease, venous thromboembolism, arterial or venous thrombosis, pulmonary embolism, restenosis, diabetic angiopathy and allograft atherosclerosis.
Owner:CENTOCOR ORTHO BIOTECH
A lower limb deep venous thrombosis thrombolysis curative effect prediction method and system based on machine learning
InactiveCN109598266AThrombolytic efficacy evaluation results are accurateImprove efficiencyMedical referencesRecognition of medical/anatomical patternsPredictive methodsThrombus
The invention discloses a lower limb deep venous thrombosis thrombolysis curative effect prediction method and system based on machine learning. The method comprises the steps: obtaining an area of interest of lower limb deep venous thrombosis from an MRI image; Performing image omics feature extraction on the region of interest of the lower limb deep venous thrombosis; And predicting the curative effect of lower limb deep venous thrombosis thrombolysis by adopting a machine learning method according to an image omics feature extraction result. The invention discloses a lower limb deep venousthrombosis thrombolysis curative effect prediction method and system based on machine learning. lower limb deep venous thrombolysis curative effect prediction is performed through image omics featureextraction and a machine learning method; The MRI imaging omics method and the machine learning technology are combined to predict the thrombolysis curative effect of the deep venous thrombosis of the lower limbs, the curative effect evaluation work can be completed through prediction before thrombolysis treatment, the method does not depend on experience of doctors any more, and the thrombolysiscurative effect prediction result is more accurate and higher in efficiency. The method can be widely applied to the field of medical image processing.
Owner:SHENZHEN UNIV +1
An automatic lower limb deep venous thrombosis segmentation method and system based on deep learning
PendingCN109685807AReduce the burden onImprove consistencyImage enhancementImage analysisAutomatic segmentationVein
The invention discloses an automatic segmentation method and system for lower limb deep venous thrombosis based on deep learning. The method comprises the following steps: using the depth learning method for detecting and positioning a thrombotic focus area of a CE-MRI image to obtain an image containing a thrombotic focus; And carrying out thrombus focus segmentation on the image containing the thrombus focus by adopting a deep learning method. According to the invention, the CE-MRI image and the deep learning technology are combined to be applied to automatic thrombus segmentation of deep vein thrombus, a thrombus focus is automatically segmented through two times of deep learning, manual participation of a doctor is not needed, the burden of the doctor is reduced, efficiency is higher,objectivity and accuracy are better, and the consistency and repeatability of a segmentation result are better. The method can be widely applied to the field of medical image processing.
Owner:广州市番禺区中心医院 +1
Synthesis, activity and application for 1,1 dimethylol-tetrahydro-beta-carboline-3-formyl-GYIGSR
ActiveCN109134603AInhibit expression activityPeptide/protein ingredientsPeptide preparation methodsVenous bloodSelectin
The invention discloses a (3S) -1, 1-Dihydroxymethyl-Tetrahydro-Beta-Carboline-3-Formyl-Gly-Tyr-Ile-Gly-Ser-Arg, discloses a preparation method thereof, discloses the anti-arterial thrombosis activity, discloses the anti-venous thrombosis activity, discloses the activity of inhibiting the GPIIb / IIIa expression, and discloses the activity of inhibiting the P-selectin expression in vivo. Therefore,the invention discloses the application in preparing anti-arterial thrombosis medicine, the application in preparing the anti-venous thrombosis medicine, the application in preparing the GPIIb / IIIa antagonist and the application in preparing P-selectin antagonist. The formulas are shown in the decription.
Owner:CAPITAL UNIVERSITY OF MEDICAL SCIENCES
Knee joint function training device
The invention discloses a knee joint function training device. The device comprises a rack, a supporting device, a driving device, a fixing pressing device and a control device; the supporting devicecomprises a supporting frame slidingly connected with a shell and vertically arranged, a foot fixing sleeve rotatably connected with the supporting frame, a calf placement frame rotatably connected with the upper end of the supporting frame and located at the side close to the upper limb of a patient and a thigh placement frame rotatably connected with the end, away from the foot fixing sleeve, ofthe calf placement frame; the other end of the thigh placement frame is rotatably connected with the end, close to the upper limb of the patient, of the shell; the fixing pressing device comprises afirst airbag belt, a second airbag belt and an intermittent inflation pressure pump; since the lower limb of the patient is subjected to isometric contraction and isotonic contraction which are closerto the physiological movement of the human body simultaneously, the venous blood flow stasis is relieved, the venous thrombosis is prevented, and the recovery of the patient is facilitated; due to the addition of the isometric contraction in the whole isotonic contraction process, part of attention of the patient in the pressurization and pressure relief process is distracted, and the pain brought to the patient is reduced.
Owner:南通市中医院
Synthesis, activity and application for 1, 1-dihydroxymethyl-tetrahydro-beta-carboline-3-formyl-GRGDS
ActiveCN109134607AInhibit expression activityPeptide/protein ingredientsPeptide preparation methodsMedicineSelectin
The invention discloses a (3S) -1, 1-Dihydroxymethyl-Tetrahydro-Beta-Carboline-3-Formyl-Gly-Arg-Gly-Asp-Ser, discloses a preparation method thereof, discloses the anti-arterial thrombosis activity, discloses the anti-venous thrombosis activity, discloses the activity of inhibiting the GPIIb / IIIa expression, and discloses the activity of inhibiting the P- selectin expression in vivo. Therefore, theinvention discloses the application in preparing anti-arterial thrombosis medicine, the application in preparing the anti-venous thrombosis medicine, the application in preparing the GPIIb / IIIa antagonist and the application in preparing P- selectin antagonist. The formulas are shown in the decription.
Owner:CAPITAL UNIVERSITY OF MEDICAL SCIENCES
Portable pneumatic massager capable of resisting deep venous thrombosis of lower limbs
The invention provides a portable pneumatic massager capable of resisting deep venous thrombosis of lower limbs, and relates to the technical field of rehabilitation instruments. The portable pneumatic massager capable of resisting deep venous thrombosis of the lower limbs comprises two sleeve cylinders which are bilaterally symmetrical, wherein a circle is slidably connected with and arranged ineach sleeve cylinder; an air bag is placed in each circle; sliding blocks are slidably connected with and arranged in each circle; an extrusion rod is fixedly connected with and arranged in each sliding block through a first spring; and a rolling ball is connected with and arranged at one side, close to the center of a circle, of each extrusion rod in a rolling mode. The portable pneumatic massager capable of resisting the deep venous thrombosis of the lower limbs has the following advantages: the effect of improving the hysteresis of a venous blood flow is achieved; the formation of the deepvenous thrombosis is prevented; the portable pneumatic massager can be applicable to patients with different leg sizes; the effect of relieving a deep venous blood flow is improved; the production cost of the massager is reduced; meanwhile, the portable pneumatic massager is small in size and light in weight; and the portable pneumatic massager is convenient to carry by adoption of the combined design of the sleeve cylinders and a treading seat.
Owner:JILIN UNIV
Medicament for treating thromboangitis obliterans and preparation method thereof
ActiveCN102600239AUnique healing effectGood treatment effectAnthropod material medical ingredientsCardiovascular disorderCentipedeMyrrh
The invention discloses a medicament for treating thromboangitis obliterans, which is formed by mixing, crushing and grinding the following components in weight parts: astragalus mongholicus, honeysuckle, Chinese angelica, leech, centipede, bombys batryticatus, earthworm, roasted liquorice, roasted frankincense, myrrh, ground beetle, scorpion, radix salviae miltiorrhizae, hemlock parsley, roasted nux vomica and cassia twig. The medicament has the functions of reinforcing qi and nourishing blood, removing cold-dampness, activating blood circulation to remove stasis, regulating meridians, supporting healthy energy, and removing blood stasis to promote tissue regeneration, and is used for treating vital energy and blood circulation obstruction caused by weak, cold and damp spleen and kidney, venation stasis, and vasculitis at tail ends of four limbs or caused by fire heat generation and yin impairment due to damp stagnation. The medicament has remarkable effect to each phase of the vasculitis, has good treatment effect to deep venous thrombosis, phlebophlogosis and other peripheral vascular diseases, and has high cure rate, quick response, stable curative effect and relapse prevention.
Owner:由丽萍
Double-cavity-catheter self-sealing venous indwelling needle
ActiveCN104399145APhysiologicalIn line with medical principlesInfusion needlesVeinSuperficial phlebitis
The invention relates to a double-cavity-catheter self-sealing venous indwelling needle which consists of an indwelling catheter 1, a working liquid bag tube 2, an infusion tube cavity 3, a needle point groove 4, a flexible connecting tube 5, a pressuring block 6, a pressure-resistant liquid bag 7, lock catches 8, a needle seat 9 and a steel needle core 10 with a semicircular section. The double-cavity-catheter self-sealing venous indwelling needle is very simple to operate, tube sealing is finished under the condition that a working liquid is completely sealed, no pollutant enters, the needle can be used continuously without complications such as secondary injuries to veins, liquid leakage, phlebitis, venous thrombosis and the like, and a patient feels comfortable. Disposable syringes and flushers are not consumed, nursing operation steps are reduced, and the nursing efficiency and the nursing quality are improved.
Owner:西藏多欣健康科技有限公司
Growth arrest specific gene 6 peptides, antibodies, compositions, methods and uses
The present invention provides novel proteins and peptides from the receptor binding region of human Growth Arrest Specific Gene 6 (Gas6) and antibodies, including specified portions or variants, specific for at least one such Gas6 peptide or fragment thereof. The aforesaid peptides can be used to generate human, primate, rodent, mammalian, chimeric, humanized and / or CDR-grafted anti-Gas6 antibodies. The invention also provides for the nucleic acids encoding such peptides and anti-Gas6 antibodies, complementary nucleic acids, vectors, host cells, and methods of making and using thereof, including therapeutic formulations, administration and devices. Fifteen novel peptide sequences from the Gas6 G domain that are implicated in Gas6 interactions with its receptors are identified, isolated, and synthesized so as to allow generation of anti-Gas6 antibodies. The peptide sequences include three ESTs that encompass regions predicted to contribute to receptor binding or that can raise anti-Gas6 antibodies. This invention provides for such antibodies to be used in modulating or treating at least one Gas6-related disease in a cell, tissue, organ, animal, or patient. Such diseases may include, but are not limited to, thromboembolic disease, ischemic disease, venous thromboembolism, arterial or venous thrombosis, pulmonary embolism, restenosis, diabetic angiopathy and allograft atherosclerosis.
Owner:CENTOCOR ORTHO BIOTECH
Phascolosoma esculenta plasmin and preparation method thereof
InactiveCN102002488ASimple extraction processReduce manufacturing costEnzymesArterial occlusionsThrombus
The invention provides phascolosoma esculenta plasmin, which is extracted from phascolosoma esculenta, and has double activities of directly dissolving fibrin and kinase. The phychemical performance of the plasmin is that: the molecular weight is between 28,000 and 32,000, the isoelectric point is between 4.6 and 6.6, the dissolution activity of fibrin does not change greatly under a temperature range between 30 and 70 DEG C, and the stability range to the pH value is between 5.0 and 9.0. The phascolosoma esculenta plasmin has the direct fibrin and kinase dissolving activities, has simple extracting process, low preparation cost and easily obtained raw materials, can be developed into intravenous injection, contains the plasmin capable of directly dissolving thrombus, and is expected to obtain better effect in treating catheter assisted thrombolysis treating peripheral arterial occlusion and deep venous thrombosis.
Owner:GUANGXI MEDICAL UNIVERSITY
Iliofemoral deep venous thrombosis moniliform eccentric sacculus thrombolysis thrombectomy catheter and using method of same
InactiveCN103212148AAchieve the effect of dissolutionImprove solubilityBalloon catheterSurgeryHydrophilic coatingBalloon catheter
Owner:SHENZHEN PEOPLES HOSPITAL
Drug compositions and methods for preventing and treating thrombosis or embolism
InactiveUS20090281074A1Potent FXa-inhibiting effectExhibit some effectBiocideOrganic chemistryDiseaseExtracorporeal circulation
Drug compositions containing a substituted diamine compound represented by formula (1):Q1-Q2-r-N(R1)-Q3-N(R2) (1)wherein Q3 represents the following groupwherein Q5 represents an alkylene group having 4 carbon atoms, R3 represents a hydrogen atom, and R4 represents a 3-6 membered heterocyclic group which may be substituted; are useful for preventing and / or treating cerebral infarction, cerebral embolism, myocardial infarction, angina pectoris, pulmonary infarction, pulmonary embolism, Buerger's disease, deep venous thrombosis, disseminated intravascular coagulation syndrome, thrombus formation after artificial valve or joint replacement, thrombus formation and reocclusion after angioplasty, systemic inflammatory response syndrome (SIRS), multiple organ dysfunction syndrome (MODS), thrombus formation during extracorporeal circulation, or blood clotting upon blood drawing.
Owner:DAIICHI SANKYO CO LTD
Thrombus prevention apparatus and methods
An apparatus and methods for the prevention or minimization of lower extremity venous thrombosis comprising an impedance component disposed at the proximal end of the lower extremity and a compression component disposed at the distal end of the lower extremity. The proximal impedance component is activated to impede return venous blood flow, preferably on the femoral vein, until blood volume in the lower extremity is maximized. In response to deactivation of the proximal compression component, the distal compression component is activated to assist return venous blood flow. The apparatus and methods enhance blood circulation in the lower extremity by increasing washout of stagnant blood from the lower extremity, particularly from the venous sinuses and valve cusps where thrombosis tends to form.
Owner:MEDSURG DEVICES
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