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Hydrogel transdermal patch containing multiple pure plant extract oil and preparation method thereof

A hydrogel transdermal patch and oil extraction technology, applied in the field of traditional Chinese medicine patches, can solve the problems of low drug content loading, insufficient cross-linking reaction, poor blood-activating effect, etc. Conducive to transdermal absorption and increase the effect of fever and blood circulation

Active Publication Date: 2018-10-16
张文涛
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Most of the existing gel patches in the market use PVPK30 or Carbomer 930 single-molecule low-density material as the cross-linked body of the gel layer molecules. Because of the small molecular weight, the cross-linking reaction is insufficient and the stability is not good. The drug is single and added in a low amount, which may easily cause the finished patch to contain low drug ingredients, poor blood circulation effect, low adhesion, and easy to fall off

Method used

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  • Hydrogel transdermal patch containing multiple pure plant extract oil and preparation method thereof
  • Hydrogel transdermal patch containing multiple pure plant extract oil and preparation method thereof
  • Hydrogel transdermal patch containing multiple pure plant extract oil and preparation method thereof

Examples

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Effect test

Embodiment 1

[0070] A transdermal hydrogel patch containing a variety of pure plant extract oils, including a gel layer and an isolation film on the surface of the gel layer and a backing cloth on the back of the gel layer. The gel layer is prepared from raw materials including the following parts by weight And get: pure plant extract oil: 100g; carbomer 940: 25g; NP800: 25g; glycerol: 225g; aluminum glycolate: 40g; PVPK90: 100g; tartaric acid: 30g; ethanol: 110g; EDTA-2Na: 60g ; Pure water: 475g. The pure plant extract oil includes the following components by weight: white mustard seed extract oil: 22.5g; cinnamon extract oil: 10g; ginger extract oil: 11g; saffron extract oil: 15g; peppermint extract oil: 14g; yellow mustard seed extract Oil: 27.5g.

[0071] The preparation method of the above-mentioned hydrogel transdermal patch containing various pure plant extract oils includes the following steps:

[0072] S1: Take pure water, add tartaric acid and stir evenly, then add PVPK90 for stirri...

Embodiment 2

[0078] A transdermal hydrogel patch containing a variety of pure plant extract oils, including a gel layer and an isolation film on the surface of the gel layer and a backing cloth on the back of the gel layer. The gel layer is prepared from raw materials including the following parts by weight And get: pure plant extract oil: 90g; carbomer 940: 10g; NP800: 25g; glycerol: 160g; aluminum glycolate: 36g; PVPK90: 110g; tartaric acid: 20g; ethanol: 120g; EDTA-2Na: 50g ; Pure water: 400g. The pure plant extract oil includes the following components by weight: white mustard extract oil: 20g; cinnamon extract oil: 10g; ginger extract oil: 10g; saffron extract oil: 15g; peppermint extract oil: 10g; yellow mustard extract oil : 25g.

[0079] The preparation method of the above-mentioned hydrogel transdermal patch containing various pure plant extract oils includes the following steps:

[0080] S1: Take pure water, add tartaric acid and stir evenly, then add PVPK90 for stirring, and stir a...

Embodiment 3

[0086] A transdermal hydrogel patch containing a variety of pure plant extract oils, including a gel layer and an isolation film on the surface of the gel layer and a backing cloth on the back of the gel layer. The gel layer is prepared from raw materials including the following parts by weight And get: pure plant extract oil: 70g; carbomer 940: 10g; NP800: 20g; glycerol: 150g; aluminum glycolate: 20g; PVPK90: 50g; tartaric acid: 10g; ethanol: 100g; EDTA-2Na: 30g ; Pure water: 400g. The pure plant extract oil includes the following components by weight in g: white mustard extract oil: 20g; cinnamon extract oil: 5g; ginger extract oil: 5g; saffron extract oil: 10g; peppermint extract oil: 5g; yellow mustard extract oil : 25g.

[0087] The preparation method of the above-mentioned hydrogel transdermal patch containing various pure plant extract oils includes the following steps:

[0088] S1: Take pure water, add tartaric acid and stir evenly, then add PVPK90 for stirring, and stir ...

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Abstract

The invention provides a hydrogel transdermal patch containing various pure plant extract oil and a preparation method thereof. The hydrogel transdermal patch comprises a gel layer, an isolating membrane and back lining cloth, wherein the isolating membrane is located on the surface of the gel layer, and the back lining cloth is located on the back side of the gel layer; and the gel layer is prepared from the following raw materials in parts by weight: 14-30 parts of the pure plant extract oil, 2-5 parts of carbomer-940, 4-7 parts of NP800, 30-50 parts of glycerol, 4-9 parts of dihydroxyaluminum aminoacetate, 10-30 parts of PVPK90, 2-9 parts of tartaric acid, 20-30 parts of ethanol, 6-16 parts of EDTA-2Na and 80-100 parts of pure water. According to the hydrogel transdermal patch, the adhesion degree of the hydrogel transdermal patch is improved, adhesion is firm, the gel stability is high, the product is finer and smoother, the viscosity of the hydrogel transdermal patch is improved,and meanwhile, the loading capacity of the plant components is improved; and a plurality of plants capable of promoting blood circulation and relieving swelling and pain are added into the raw materials of the gel layer, so that the heating and blood circulation promoting properties of the product are improved, the application effect of the product is improved, and the application time of the product is prolonged.

Description

Technical field [0001] The invention belongs to the field of traditional Chinese medicine patches, and particularly relates to a transdermal hydrogel patch containing various pure plant extract oils and a preparation method thereof. Background technique [0002] Hydrogel patch is a new type of external patch with high technology content, wide application range and convenient use in the world today. In the early 1970s, Japan, Europe and other countries have begun to develop medical hydrogel patches. With the continuous development of the pharmaceutical industry, this new dosage form has developed in my country in recent years. The hydrogel patch matrix has a large drug load, strong moisture retention, good compatibility with the skin, and aging resistance. It can be peeled off repeatedly, and the drug can be terminated at any time. The dosage is accurate, and the blood drug concentration is balanced without peaks and valleys, which can reduce toxicity Side effects, no organic sol...

Claims

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Application Information

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IPC IPC(8): A61K9/70A61K47/32A61K36/9068A61P29/00
CPCA61K9/7023A61K36/31A61K36/534A61K36/54A61K36/88A61K36/9068A61K47/32A61P29/00A61K2300/00
Inventor 张文涛万楠楠
Owner 张文涛
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