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A micro-hybrid chip based on chaotic flow

A micro-mixing and chip technology, applied in mixers, laboratory containers, chemical instruments and methods, etc., can solve problems such as integration difficulties and complex microstructures, and achieve the effect of improving integration

Inactive Publication Date: 2020-12-11
SHENYANG POLYTECHNIC UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But "cut-and-stack" operations on fluids require complex microstructures, so it is very difficult to integrate "baker" micromixers on the volume-limited μTAS chip

Method used

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  • A micro-hybrid chip based on chaotic flow
  • A micro-hybrid chip based on chaotic flow
  • A micro-hybrid chip based on chaotic flow

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0084] Preparation method of chaotic flow micro-mixer based on horseshoe transformation:

[0085] 1) Use an engraving machine or a 3D printer to make the first chip liquid inlet 5, the second chip liquid inlet 6, the chip liquid outlet 7, the T-shaped pre-mixing channel 1, and the new U-shaped "bend" on the polymer base material Folding" channel 2-2, new reverse U-shaped "bending and folding" channel 3-2, chip outlet channel 11;

[0086] 2) The substrates with microstructures are sealed by using bonding methods such as organic solvent miscible immersion bonding method or organic solvent fumigation bonding method.

Embodiment

[0088] When a=200μm, according to Figure 2 to Figure 19 The T-shaped pre-mixing channel, micro-mixing unit, and micro-mixer structure are shown, and the microstructures are processed on the polymethyl methacrylate polymer base material using an ultra-precision engraving machine.

[0089] 1) According to the volume ratio V 三氯甲烷 :V 乙醇 = 1:10 prepare 110 ml of anhydrous ethanol and chloroform miscible solution. Wet the two substrates with microstructures in the above-mentioned miscible solution respectively, fix them under a microscope with a quartz glass fixture, and put the fixed chips into a petri dish filled with the miscible solution. Put the petri dish into the drying oven immediately, set the temperature at 40°C, and bond for 10 minutes. The cross-sections of the microchannels on the micromixer chip before and after bonding assembly are as follows: Figure 22 shown.

[0090] 2) Fluorescein Isothiocyanate (FITC) and Rhodamine B (Rhodamine B) with a concentration of 1 ...

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Abstract

The invention relates to a micro-mixing chip based on chaotic flow, which includes a cover sheet and a bottom sheet bonded together. The cover sheet includes a first chip liquid inlet, a second chip liquid inlet, a chip liquid outlet, and a plurality of new reverse U Type "bend and fold" channel and chip liquid outlet channel, the backsheet includes T-shaped pre-mixing channel and multiple new U-shaped "bend and fold" channels, the T-shaped pre-mixing channel is connected with the first chip liquid inlet and The liquid inlet of the second chip is connected, and the lower end of the "T" shape is a pre-mixing channel. The liquid port is connected. The invention imitates the "horseshoe transformation" process, designs a micron-scale chip structure, performs operations such as "squeezing and stretching", "bending and folding" on the fluid, and induces the moving fluid under laminar flow conditions to generate chaotic flow, thereby promoting the improvement of mixing efficiency. promote.

Description

technical field [0001] The invention belongs to the field of micro-electro-mechanical systems (Micro-electro Mechanical Systems, MEMS), and relates to a micro total analysis system (Micro total analysis systems, μTAS) chip and a manufacturing method thereof. Background technique [0002] Except for the injection pressure, the passive micro-mixer does not require other external incentives, and is more suitable for integration on the micro-total analysis system chip, and realizes the rapid detection of trace samples together with other functional modules. However, on the μTAS chip with a structural feature size of 0.1 μm to 1 mm, the fluid generally moves under laminar flow conditions with a low Reynolds number (Re), so it is necessary to operate the fluid with the help of a special microstructure to improve the mixing efficiency. the goal of. T-shape and Y-shape mixers are passive mixers with the simplest structure. They mainly use intermolecular diffusion to achieve mixing....

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01L3/00
CPCB01F33/30
Inventor 张贺揣荣岩李新张冰张英杰
Owner SHENYANG POLYTECHNIC UNIV