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A preparation method of slow-release antibacterial phase-change medical dressing based on double-walled microcapsules

A technology of microcapsules and phase change materials, which is applied in the direction of microcapsules, capsule delivery, and pharmaceutical formulations, and can solve the problems of poor compatibility between phase change materials and spinning solutions, affecting the effect of heat preservation and temperature adjustment, and poor adhesion High-level problems, to achieve the effect of improving storage reliability, improving durability, and low bulk density

Active Publication Date: 2021-04-06
海南中生制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Known from above-mentioned prior art, can prepare the non-woven fabric material with phase-change function by adding phase change material in the spinning solution through spinning process, this non-woven fabric is used as medical dressing, promotes the healing of wound, but Directly add the phase change material into the spinning solution, the compatibility between the phase change material and the spinning solution is not good, the adhesion is not high, and it is easy to leak out during use, which affects the effect of heat preservation and temperature regulation

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] (1) Add 1 g of expanded perlite with a particle size of less than 0.3 mm into 20 mL of 0.5% sodium dodecylbenzenesulfonate solution, stir, filter and dry to obtain pretreated expanded perlite.

[0028] (2) Add the pretreated expanded perlite to the neopentyl glycol liquid phase change material, vacuum filter at 0.01 Pa for 10 min, and stir at 50 r / min for 5 min to obtain the phase change composite core material.

[0029] (3) According to the mass ratio of nano-silver particles, phase-change composite core material and chitosan is 0.3:1:3, nano-silver particles and phase-change composite core material are added to the chitosan solution, after mixing evenly, Add sodium alginate binder and glutaraldehyde cross-linking agent while stirring, continue to stir and react, suction filter, wash, cool and dry, and obtain phase-change microcapsules containing antibacterial inner walls, wherein the content of phase-change materials in phase-change composite core materials 55%.

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Embodiment 2

[0033] (1) Add 1 g of expanded perlite with a particle size of less than 0.3 mm into 30 mL of 2% sodium dodecylbenzenesulfonate solution, stir, filter and dry to obtain pretreated expanded perlite.

[0034] (2) Add the pretreated expanded perlite to the paraffin liquid phase change material, vacuum filter for 30 minutes at a vacuum degree of 0.01-0.5 Pa, and stir at a speed of 150 r / min for 10 minutes to obtain a phase change composite core material.

[0035](3) According to the mass ratio of nano-silver particles, phase-change composite core material and chitosan as 0.5:1:6, nano-silver particles and phase-change composite core material are added to the chitosan solution, after mixing evenly, Add sodium alginate binder and glutaraldehyde cross-linking agent while stirring, continue to stir and react, suction filter, wash, cool and dry, and obtain phase-change microcapsules containing antibacterial inner walls, wherein the content of phase-change materials in phase-change compo...

Embodiment 3

[0039] (1) Add 1 g of expanded perlite with a particle size of less than 0.3 mm into 20 mL of 2% sodium dodecylbenzenesulfonate solution, stir, filter and dry to obtain pretreated expanded perlite.

[0040] (2) Add the pretreated expanded perlite to the polyethylene glycol liquid phase change material, vacuum filter for 30 minutes at a vacuum degree of 0.01 Pa, and stir at a speed of 50 r / min for 10 minutes to obtain a phase change composite core material.

[0041] (3) According to the mass ratio of nano-silver particles, phase-change composite core material and chitosan is 0.3:1:6, nano-silver particles and phase-change composite core material are added to the chitosan solution, after mixing evenly, Add sodium alginate binder and glutaraldehyde cross-linking agent while stirring, continue to stir and react, suction filter, wash, cool and dry, and obtain phase-change microcapsules containing antibacterial inner walls, wherein the content of phase-change materials in phase-chang...

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Abstract

The invention provides a preparation method of a slow-release antibacterial phase-change medical dressing based on double-walled microcapsules, comprising the following steps: adding expanded perlite to a surfactant solution for pretreatment, adding it to a liquid phase-change material, and vacuuming Filtrate and stir to obtain the phase-change composite core material; the nano-silver particles and the phase-change composite core material are added to the chitosan solution, after mixing evenly, add the binder and cross-linking agent while stirring, continue the stirring reaction, pump Filter, wash, cool and dry to obtain phase-change microcapsules containing antibacterial inner walls; add the phase-change microcapsules containing antibacterial inner walls to sodium alginate solution, mix well, add calcium chloride solution dropwise, and adjust the pH of the system to 3-4 , slowly stirred for 5-10min, left standing, filtered and washed, and vacuum-dried to obtain double-wall slow-release antibacterial phase-change microcapsules; add double-wall slow-release antibacterial phase-change microcapsules to the spinning solution, and heat while adding the cross-linking agent dropwise Agitated and spun to obtain a slow-release antibacterial phase-change medical dressing based on double-walled microcapsules.

Description

technical field [0001] The invention belongs to the technical field of medical dressing materials, and in particular relates to a preparation method of a slow-release antibacterial phase-change medical dressing based on double-walled microcapsules. Background technique [0002] Medical dressing is an extremely important class of medical textiles. Its main function is to control the exudate of the wound and protect the wound from contamination by bacteria and dust particles, and to provide a warm and comfortable environment for the wound, which can speed up the healing of the wound. , but the temperature and humidity of the external environment have a great influence on the body temperature of patients with burns and trauma, so how to maintain a constant body temperature at the wound is a very important issue. [0003] A phase change material is a kind of internal molecular form that will change between the crystalline region and the amorphous region within a specific tempera...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L26/00
CPCA61L26/0004A61L26/0023A61L26/0061A61L26/0066A61L2300/104A61L2300/404A61L2300/622C08L5/08C08L5/04
Inventor 徐亚维
Owner 海南中生制药有限公司