Temperature sensitive hydrogel composition including nucleic acid and chitosan

A temperature-sensitive hydrogel and composition technology, which is applied in the directions of medical preparations containing active ingredients, drug delivery, organic active ingredients, etc., can solve problems such as composition differences, and achieve the effect of improving retention and adhesion time.
CN108697805AActive Publication Date: 2018-10-23PHARMARES PROD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
PHARMARES PROD
Publication Date
2018-10-23

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Abstract

The present invention provides a temperature sensitive hydrogel composition including a nucleic acid and chitosan. Since the hydrogel has excellent biocompatibility and biostability, and simultaneously has sol-gel phase transition properties depending on temperature changes, the hydrogel is present in a sol state at room temperature and becomes a gel when the hydrogel is injected into the human body or applied on the surface of epithelial skin and the temperature increases. Thus, the temperature-sensitive hydrogel of the present invention can be directly injected into and applied on certain parts requiring treatment and the retention and attaching time of a drug is increased through gelation depending on the temperature so that drug efficacy is sufficiently exhibited. Therefore, it is expected that the temperature-sensitive hydrogel of the present invention can be utilized for various treatments.
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Description

technical field

[0001] The invention relates to a thermosensitive hydrogel composition comprising nucleic acid and chitosan. Background technique

[0002] Hydrogel refers to a polymer structure with a three-dimensional network structure containing an aqueous phase (Rohindra D.R. et al., 2004), through the formation of covalent bonds or non-covalent bonds between hydrophilic polymers. valence bonds to form (HwangJunseok et al., 2008). Since hydrogels composed of various hydrophilic polymers have high water content and excellent biocompatibility, many researches have been conducted on their application as biomaterials. Hydrogels that are particularly sensitive to stimuli such as pH, temperature, electric field, magnetic field, light, ultrasound, etc., can be used in drug delivery systems with controlled release depending on the presence or absence of stimuli (Hoffman A.S., 2002).

[0003] Among them, as far as thermosensitive hydrogels are concerned, they are most widely stu...

Claims

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