31 results about "Sol-Gel Phase Transition" patented technology

The present invention relates to a biodegradable and thermosensitive poly(organophosphazene) with a functional group, a preparation method thereof, and a use thereof for delivery of bioactive substances. According to the present invention, poly(organophosphazene) is a phosphagen-based polymer showing biodegradability, thermosensitivity, and sol-gel phase transition depending on temperature change, whereby when administered into a living body with bioactive substances such as drugs, the poly(organophosphazene) forms a gel-phase at body temperature to be capable of controlled release of the bioactive substances. Further, the poly(organophosphazene) has functional groups to chemically bind with bioactive substances through an ionic bond, covalent bond, or coordinate covalent bond to be capable of a sustained release of the bioactive substances due to its good binding property. Therefore, the poly(organophosphazene) is useful as a delivery material for bioactive substances.

The present invention relates to a thermosensitive phosphazene-based polymer having a degradation controllable ionic group, a use thereof, and a use thereof as a material for delivering bioactive substances. The phosphazene-based polymer according to the present invention has the thermosensitivity of showing the temperature-dependent sol-gel phase transition. Thus, it forms a gel phase at the body temperature when it is injected into the body to make it easy to control the release of bioactive substances such as drugs, and has the functional groups capable of making chemical bonds such as ionic bond, covalent bond, coordinate bond, etc. with drugs and thus is excellent in bearing the drugs. Since it can control the degradation rate depending on the kind of ionic group, it can selectively control the release time depending on the characteristics of drugs. Furthermore, it has an excellent biocompatibility and thus is very useful as a material for delivery of bioactive substances such as drugs, etc.

There is provided in the present invention a composition for inhibiting adhesion comprising polymers that are dissolved in an aqueous solution and have temperature sensitivity showing a sol-gel phase transition dependant upon temperature, wherein the polymer solution in a sol state becomes a gel state by body temperature and is thus stably coated within tissues whereby it functions as a membrane inhibiting adhesion and as time lapses, it is degraded into low molecular weight surfactants and bio-degradable single molecular substances whereby they can be absorbed into body and the degraded products can bring about secondary adhesion inhibiting effects.

The invention provides a stereolithographic resin composition including a photo-curable component, a resin having a function of causing a reversible, quick sol-gel phase transition based on temperature change, and a filler, and a stereolithographic method using the resin composition.

A fuel cell system of the present invention includes: a fuel cell stack (1) composed by stacking a plurality of single cells, each single cell having: a membrane electrode assembly in which electrode catalyst layers (3) and gas diffusion layers (4) are disposed on both surfaces of an electrolyte membrane (2) formed of a gel electrolyte with a sol-gel phase transition temperature; and separators (5) disposed on both sides of the membrane electrode assembly; and a temperature adjusting apparatus (12) which adjusts a temperature of the electrolyte membrane in the single cell. In such a way, a defect such as a pinhole that has occurred in the electrolyte membrane (2) can be solved.

The present invention relates to a tissue-engineered scaffold prepared by using a biocompatible and injectable hydrogel, and particularly to a tissue-engineered scaffold capable of regenerating or recovering an injured spinal nerve for central nervous system after being implanted to connect neurons, prepared by combining an adult stem cell or a nerve cell with a physiologically active material on tissue-engineered carriers comprising biocompatible and temperature-sensitive polyethylene glycol / polyester block copolymer or biocompatible and injectable hydrogel made of small intestinal submucosa tissue powder with sol-gel phase transition behavior.

The present invention provides a temperature sensitive hydrogel composition including a nucleic acid and chitosan. Since the hydrogel has excellent biocompatibility and biostability, and simultaneously has sol-gel phase transition properties depending on temperature changes, the hydrogel is present in a sol state at room temperature and becomes a gel when the hydrogel is injected into the human body or applied on the surface of epithelial skin and the temperature increases. Thus, the temperature-sensitive hydrogel of the present invention can be directly injected into and applied on certain parts requiring treatment and the retention and attaching time of a drug is increased through gelation depending on the temperature so that drug efficacy is sufficiently exhibited. Therefore, it is expected that the temperature-sensitive hydrogel of the present invention can be utilized for various treatments.

An inkjet recording method comprising: shooting to a recording medium an active-light-ray-curable inkjet ink including a photopolymerizable compound, a wax, a photopolymerization initiator, and a coloring material, and that undergoes reversible sol-gel phase transition relative to temperature; and curing the ink by irradiating an active light ray to the ink that has been shot to the recording medium, wherein the ink including a (meta) acrylate compound (B) having a molecular weight of 300-1500 and a C log P value within the range 4.0 to 7.0, the wax content being 1.0-10 percent by mass of the total mass of the ink, and the temperature of the recording medium at active light ray irradiation being set such that the saturation solubility of the wax with respect to the ink constitutes 0.5 percent by mass or less. According to this image-forming method, blooming is suppressed.

A two-component, molecular-recognition gelation strategy that enables cell encapsulation without the need for environmental triggers is provided. The two components, which in one example contain WW and polyproline-rich peptide domains that interact via hydrogen bonds, undergo a sol-gel phase transition upon simple mixing. Hence, physical gelation is induced by the mixing of two components at constant environmental conditions, analogous to the formation of chemically crosslinked epoxies by the mixing of two components. Variations in the molecular-level design of the two components are used to predictably tune the association energy and hydrogel viscoelasticity. These hetero-assembly physical hydrogels encapsulate neural progenitor cells at constant physiological conditions within 10 seconds to create uniform 3D cell suspensions that continue to proliferate, differentiate, and adopt well-spread morphologies.

The present invention provides a temperature sensitive hydrogel composition including a nucleic acid and chitosan. Since the hydrogel has excellent biocompatibility and biostability, and simultaneously has sol-gel phase transition properties depending on temperature changes, the hydrogel is present in a sol state at room temperature and becomes a gel when the hydrogel is injected into the human body or applied on the surface of epithelial skin and the temperature increases. Thus, the temperature-sensitive hydrogel of the present invention can be directly injected into and applied on certain parts requiring treatment and the retention and attaching time of a drug is increased through gelation depending on the temperature so that drug efficacy is sufficiently exhibited. Therefore, it is expected that the temperature-sensitive hydrogel of the present invention can be utilized for various treatments.

The invention discloses a preparation method of a biological 3D printing ink by adjusting gel-sol phase-transition temperature. The method controls the sol-gel phase-transition temperature of a gelatin / sodium alginate 3D printing hydrogel system to control the temperature in a most appropriate temperature range for cell growth, and a cellulosic 3D printing technology is then used to print a high-resolution cartilage scaffold to improve the printability and biocompatibility of the hydrogel material. The inorganic nanoparticles are added to the basic hydrogel system can improve the mechanical properties of the cartilage scaffold, which can solve the technical problem that the printing moulding temperature is not matched with the cell growth temperature and the mechanical properties of the hydrogel material are not good.

The purpose of the present invention is to provide an actinic radiation curable inkjet ink which has less color mixing, which can obtain white ink with fewer surface irregularities and excellent smoothness, which has excellent actinic radiation transmittance and curability, and which enables sol-gel phase transition by temperature change, and to provide an inkjet image forming method, and a recording medium on which an image has been formed using the inkjet ink. This purpose is achieved by an actinic radiation curable inkjet ink that contains a photopolymerizable compound, a photo initiator, a gelling agent, and a white pigment, wherein the white pigment contains titanium oxide, the gelling agent contains at least one type of gelling agent A that contains an alkyl chain comprising a straight chain portion with 12-26 carbon atoms, wherein the content of the gelling agent A is 5-35 mass % of the content of the titanium oxide.

A chiral nematic liquid crystal composition, characterized in that a self-organizing type gelling agent is contained and the phase transition temperature between liquid crystal and isotropic phases is higher than the sol-gel transition temperature, a liquid crystal display device wherein the chiral nematic liquid crystal composition is put and held between a pair of substrates having an electrode, and a method for producing a liquid crystal display device wherein the chiral nematic liquid crystal composition is heated to a temperature of not lower than the phase transition temperature between liquid crystal and isotropic phases and then cooled down to room temperature.

The invention discloses a fat tertiary diurea micromolecule gelling agent and a thixotropic molecular gel thereof. The gelling agent molecules contain fatty tertiary amines and ureido fragment, and can be dissolved into dichloromethane, tetrahydrofuran, acetone, benzene, toluene, paraxylene, ortho-xylene, xylene, styrene, butyl acrylate, silylated agent through heating treatment, and when room temperature cools down, a stable shearing thixotropic molecule gel can be formed; sol-gel phase transition accelerates and sol-gel phase transition is reversible by 100%, and the phase transition can be repeated for at least 15 times. Organic carboxylates are added to the molecular gel, so that the thixotropic molecular gel with higher rheological properties can be obtained. These molecular gels are expected to be used as benign media for preparing flawless crystal of organic or inorganic materials.

A two-component, molecular-recognition gelation strategy that enables cell encapsulation without the need for environmental triggers is provided. The two components, which in one example contain WW and polyproline-rich peptide domains that interact via hydrogen bonds, undergo a sol-gel phase transition upon simple mixing. Hence, physical gelation is induced by the mixing of two components at constant environmental conditions, analogous to the formation of chemically crosslinked epoxies by the mixing of two components. Variations in the molecular-level design of the two components are used to predictably tune the association energy and hydrogel viscoelasticity. These hetero-assembly physical hydrogels encapsulate neural progenitor cells at constant physiological conditions within 10 seconds to create uniform 3D cell suspensions that continue to proliferate, differentiate, and adopt well-spread morphologies.

The invention relates to a side-chain type liquid crystal polymer liquid crystal physical gel material and a preparation method thereof. The material contains the following components in percentages by mass: 90.0-99.0% of a liquid crystal material and 1.0-10.0% of a side-chain type liquid crystal polymer. By taking a small molecular liquid crystal as a working substance and the side-chain type liquid crystal polymer as a supporting material, the prepared liquid crystal physical gel material is high in modulus (the energy storage modulus can reach 104Pa above), good in thermal stability (the sol-gel transition temperature exceeds 190 DEG C) and high in small molecular liquid crystal content, and meanwhile, can adjust the chemical structure of the side-chain type liquid crystal polymer to regulate the sol-gel phase transition temperature of the liquid crystal physical gel so as to meet the using demand of different conditions.

A fuel cell system of the present invention includes: a fuel cell stack (1) composed by stacking a plurality of single cells, each single cell having: a membrane electrode assembly in which electrode catalyst layers (3) and gas diffusion layers (4) are disposed on both surfaces of an electrolyte membrane (2) formed of a gel electrolyte with a sol-gel phase transition temperature; and separators (5) disposed on both sides of the membrane electrode assembly; and a temperature adjusting apparatus (12) which adjusts a temperature of the electrolyte membrane in the single cell. In such a way, a defect such as a pinhole that has occurred in the electrolyte membrane (2) can be solved.

Disclosed is a frequency-selective signal damper including: a viscous polymer exhibiting non-Newtonian fluid behavior; and hydrogel exhibiting sol-gel phase transition. The viscous polymer exhibits shear thinning in a damping region or a noise region, and the hydrogel has a sol phase in the damping region or the noise region. The viscous polymer is gelatin, and the hydrogel is chitosan.

The invention discloses a fat tertiary diurea micromolecule gelling agent and a thixotropic molecular gel thereof. The gelling agent molecules contain fatty tertiary amines and ureido fragment, and can be dissolved into dichloromethane, tetrahydrofuran, acetone, benzene, toluene, paraxylene, ortho-xylene, xylene, styrene, butyl acrylate, silylated agent through heating treatment, and when room temperature cools down, a stable shearing thixotropic molecule gel can be formed; sol-gel phase transition accelerates and sol-gel phase transition is reversible by 100%, and the phase transition can be repeated for at least 15 times. Organic carboxylates are added to the molecular gel, so that the thixotropic molecular gel with higher rheological properties can be obtained. These molecular gels are expected to be used as benign media for preparing flawless crystal of organic or inorganic materials.

There is provided in the present invention a composition for inhibiting adhesion comprising polymers that are dissolved in an aqueous solution and have temperature sensitivity showing a sol-gel phase transition dependant upon temperature, wherein the polymer solution in a sol state becomes a gel state by body temperature and is thus stably coated within tissues whereby it functions as a membrane inhibiting adhesion and as time lapses, it is degraded into low molecular weight surfactants and bio-degradable single molecular substances whereby they can be absorbed into body and the degraded products can bring about secondary adhesion inhibiting effects.

The invention discloses a preparation method of biological 3D printing ink that can regulate the gel-sol phase transition temperature. The invention controls the sol-gel phase transition temperature of the gelatin / sodium alginate 3D printing hydrogel system. In the temperature range most suitable for cell growth. Then, a high-resolution cartilage scaffold was printed using cell 3D printing technology to improve the printability and biocompatibility of the hydrogel material. Adding inorganic nanoparticles to this basic hydrogel system can improve the mechanical properties of the cartilage scaffold, thereby solving the technical problems of the mismatch between the printing temperature and the cell growth temperature and the poor mechanical properties of the hydrogel material.

The invention discloses a cellulose composite microsphere, a preparation method thereof and application. The particle size of the cellulose composite microsphere is 1mum-1200mum, the specific surface area of the cellulose composite microsphere is 100m<2> / g-500m<2> / g, and the aperture of the cellulose composite microsphere is 200nm-900nm. The preparation method comprises the following steps of: preparing a mixture solution of cellulose and a composite material by using the cellulose as a matrix, a polymer material as composite material and a water solution of alkali / urea or alkali / thiourea as a solvent, and obtaining the cellulose composite microsphere through sol-gel phase transition and cross-linking agent cross linkage. The advantages of cellulose microsphere are reserved by the cellulose composite microsphere, and due to the adding of the composite material, new functional groups are simultaneously added for the surface of the microsphere and further decoration and modification are facilitated. An organic solvent used in the preparation method disclosed by the invention can be reused, the whole preparation technology is simple, low in time consuming, undemanding for equipment and convenient for industrial production, and the prepared cellulose composite microsphere has a good flow property and mechanical property and a wide application.