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Composition for inhibiting adhesion

A composition and polymer technology, applied in the direction of drug combination, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve the problem of no adhesion inhibitor developed

Active Publication Date: 2013-05-01
SAMYANG HLDG CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0022] Therefore, it can be said that no adhesion inhibitor with ideal conditions and successful effects has been developed so far, and the development of such an ideal and effective adhesion inhibitor is urgently needed

Method used

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  • Composition for inhibiting adhesion
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  • Composition for inhibiting adhesion

Examples

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preparation example 1

[0113] Preparation Example 1. Synthesis of a multi-block copolymer composed of Poloxamer 407 using succinyl chloride

[0114] 10g Poloxamer 407 (Pluronic F-127, BASF, molecular weight: 12,500 Daltons, PEO:PPO=101:56) was poured into a 100-ml single-neck round-bottom flask, and heated in an oil bath heated at 120°C, and then heated for 2 hours It eliminates the water contained in the polymer and reduces pressure at the same time. After the reduced pressure was removed, the reaction temperature was set to 100°C while flowing nitrogen, and then 100 ml of acetonitrile was added to the flask. The reaction flask is equipped with a Dean Stark device and a cooling device.

[0115] After removing 20 ml of acetonitrile by steaming off through the Dean-Stark device to completely remove the water in the reactant, 1 equivalent of succinyl chloride was added to the reservoir of the Dean-Stark device and reacted for 24 hours. After 24 hours, 96ul of succinyl chloride was added to the Dean-Sta...

preparation example 2

[0118] Preparation Example 2. Using adipoyl dichloride to synthesize a multi-block copolymer composed of poloxamer 188

[0119] In addition to using Poloxamer 188 (Pluronic F-68, BASF, molecular weight: 8000 Daltons, PEO:PPO=80:27) as the basic unit of the multi-block copolymer and using adipoyl chloride as the dicarboxylic acid linker, according to the preparation example 1 The same method used in the synthesis of a multi-block copolymer with an average molecular weight of 160,000. By using nuclear magnetic resonance to generate a peak near 4.2 ppm and analysis of the terminal peak due to the introduction of dicarboxylic acid, the prepared multi-block copolymer was identified as a poloxamer linked by dicarboxylic acid.

preparation example 3

[0120] Preparation Example 3. Synthesis of a multi-block copolymer composed of Poloxamer 237 using succinyl chloride

[0121] In addition to using poloxamer 237 (BASF, molecular weight: 7000 Daltons, PEO:PPO=64:37) as the basic unit of the multi-block copolymer, succinyl chloride is used as the dicarboxylic acid linking group, according to the preparation example Using the same method in 1, synthesize a multi-block copolymer with an average molecular weight of 150,000. By using nuclear magnetic resonance to generate a peak near 4.2 ppm and analysis of the terminal peak due to the introduction of dicarboxylic acid, the prepared multi-block copolymer was identified as a poloxamer linked by dicarboxylic acid.

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Abstract

There is provided in the present invention a composition for inhibiting adhesion comprising polymers that are dissolved in an aqueous solution and have temperature sensitivity showing a sol-gel phase transition dependant upon temperature, wherein the polymer solution in a sol state becomes a gel state by body temperature and is thus stably coated within tissues whereby it functions as a membrane inhibiting adhesion and as time lapses, it is degraded into low molecular weight surfactants and bio-degradable single molecular substances whereby they can be absorbed into body and the degraded products can bring about secondary adhesion inhibiting effects.

Description

[0001] Cross reference of related applications [0002] This application claims the priority and rights of Korean patent application 10-2006-0009849 filed on February 1, 2006, which is incorporated herein by reference for all purposes as if it were fully described herein. Background of the invention [0003] (a) Field of invention [0004] The present invention relates to a composition for inhibiting adhesion, which comprises a water-soluble and temperature-sensitive polymer showing a sol-gel phase transition according to temperature, wherein the polymer solution undergoes a phase transition from a sol state to a gel state due to body temperature , And therefore stably smeared in the tissue, so that it acts as a barrier to inhibit adhesion, and over time, it degrades into low-molecular-weight surfactants and biodegradable monomolecular substances, where the degradation products show two Secondary adhesion inhibition effect. [0005] (b) Description of related technology [0006] Adhes...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/765A61P41/00
CPCA61L31/145A61L26/0076A61K31/765A61L26/008A61L31/06A61L26/0019A61P17/02A61P41/00C08L71/02A61K47/00
Inventor 崔仁子徐敏孝金峯五沈明燮
Owner SAMYANG HLDG CORP
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