Sucrose fine particles and preparation method, equipment and application thereof

A fine particle, sucrose technology, applied in lighting and heating equipment, powder suspension granulation, pharmaceutical formulations, etc., can solve the problems of unsmooth feeding, poor mixing, poor fluidity of powdered sugar, etc. Good solubility and good compressibility

Inactive Publication Date: 2018-11-02
沈惠 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Ordinary sucrose and crushed sugar powder cannot be directly compressed in one step in the production of tablets, that is, all raw and auxiliary materials are mixed evenly at one time and then compressed. Exist in the original granules in the tablet, which affects the appearance of the tablet and the performance of dissolution and disintegration; and after the sucrose is crushed into powdered sugar, although the dissolution performance is improved, the fluidity of the powdered sugar is very poor, and the mixing is poor. Unable to smoothly unload during tablet product

Method used

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  • Sucrose fine particles and preparation method, equipment and application thereof
  • Sucrose fine particles and preparation method, equipment and application thereof
  • Sucrose fine particles and preparation method, equipment and application thereof

Examples

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Embodiment 1

[0042] The preparation of embodiment 1 sucrose fine particle

[0043] Commercially available sucrose is pulverized to obtain powdered sugar with a particle size of 20-30 meshes. The obtained powdered sugar is blown up with hot air in the fluidized bed, and water is sprayed at the same time. The ratio of the volume of the fluidized bed to the weight of the material is 10.75L / KG, the pressure of the water jet pump is 3 kg, and the hot air volume is 8000 cubic meters per hour. The prepared sucrose fine particles have a particle size of 60 meshes, an apparent density of 0.53 g / ml, and an angle of repose of 32°.

Embodiment 2

[0044] The preparation of embodiment 2 sucrose fine particles

[0045] Pulverize sucrose to obtain powdered sugar with a particle size of 20-30 meshes, blow up the obtained powdered sugar with hot air in the fluidized bed, and spray water at the same time, the ratio of the volume of the fluidized bed to the weight of the material is 10.75L / KG , the pressure of the water jet pump is 5 kg, and the hot air volume is 8000 cubic meters per hour. The prepared sucrose fine particles have a particle size of 70 meshes, an apparent density of 0.48 g / ml, and an angle of repose of 32°.

Embodiment 3

[0046] The preparation of embodiment 3 sucrose fine particles

[0047] Pulverize sucrose to obtain powdered sugar with a particle size of 20-30 meshes, blow up the obtained powdered sugar with hot air in the fluidized bed, and spray water at the same time, the ratio of the volume of the fluidized bed to the weight of the material is 10.75L / KG , the pressure of the water jet pump is 8 kg, and the hot air volume is 5000 cubic meters per hour. The prepared sucrose fine particles have a particle size of 80 meshes, an apparent density of 0.43 g / ml, and an angle of repose of 32°.

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Abstract

The invention belongs to the field of drug auxiliary materials, and particularly relates to sucrose fine particles and a preparation method, equipment and application thereof. The sucrose fine particles at least comprise 99.5% of sucrose, the grain size is 40-100 meshes, the apparent density is 0.4-0.6 g/ml, the angle of repose is 32-35 degrees, the mobility, the solubleness and the compressibility are good, and the sucrose fine particles can serve as pharmaceutic adjuvants and can be used for being tableted directly; and according to the preparation method, by control over the ratio of the volume of a fluidized bed and the weight of the material and pressure and hot blast rate of a water spraying pump, the sucrose fine particles which can be used for being tableted directly can be prepared.

Description

technical field [0001] The invention belongs to the field of pharmaceutical excipients, and in particular relates to a fine sucrose granule and a preparation method, equipment and application thereof. Background technique [0002] Sucrose is an important excipient in pharmaceutical preparations. It can be used as a sweetener and a filler for solid preparation tablets, and it plays the role of flavor correction and excipient. Sucrose is widely used in pharmaceutical preparations. At present, its application forms at home and abroad are as follows Several: [0003] 1. Crystalline sucrose: sucrose crystals, which are used as sweeteners, flavoring agents, fillers, binders, and coating materials for sugar-coated tablets in preparations. When used in tablets, it generally cannot be directly compressed, but needs to be crushed into powdered sucrose for use; [0004] 2. Sucrose powder: The sucrose powder recorded in USPNF20 is a mixture of sucrose (C12H22O11) and corn starch, cont...

Claims

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Application Information

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IPC IPC(8): A61K47/26A61K9/20B01J2/16F26B3/084
CPCA61K47/26B01J2/16F26B3/084A61K9/2018
Inventor 沈惠母泽波
Owner 沈惠
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