Sucrose fine particles and preparation method, equipment and application thereof

Abstract

The invention belongs to the field of drug auxiliary materials, and particularly relates to sucrose fine particles and a preparation method, equipment and application thereof. The sucrose fine particles at least comprise 99.5% of sucrose, the grain size is 40-100 meshes, the apparent density is 0.4-0.6 g / ml, the angle of repose is 32-35 degrees, the mobility, the solubleness and the compressibility are good, and the sucrose fine particles can serve as pharmaceutic adjuvants and can be used for being tableted directly; and according to the preparation method, by control over the ratio of the volume of a fluidized bed and the weight of the material and pressure and hot blast rate of a water spraying pump, the sucrose fine particles which can be used for being tableted directly can be prepared.

Description

technical field [0001] The invention belongs to the field of pharmaceutical excipients, and in particular relates to a fine sucrose granule and a preparation method, equipment and application thereof. Background technique [0002] Sucrose is an important excipient in pharmaceutical preparations. It can be used as a sweetener and a filler for solid preparation tablets, and it plays the role of flavor correction and excipient. Sucrose is widely used in pharmaceutical preparations. At present, its application forms at home and abroad are as follows Several: [0003] 1. Crystalline sucrose: sucrose crystals, which are used as sweeteners, flavoring agents, fillers, binders, and coating materials for sugar-coated tablets in preparations. When used in tablets, it generally cannot be directly compressed, but needs to be crushed into powdered sucrose for use; [0004] 2. Sucrose powder: The sucrose powder recorded in USPNF20 is a mixture of sucrose (C12H22O11) and corn starch, cont...

AI Technical Summary

Problems solved by technology

Ordinary sucrose and crushed sugar powder cannot be directly compressed in one step in the production of tablets, that is, all raw and auxiliary materials are mixed evenly at one time and then compressed. Exist in the original granules in the tablet, which affects the appearance of the tablet and the performance of dissolution and disintegration; and after the sucrose is crushed into powdered sugar, although the dissolution performance is improved, the fluidity of the powdered sugar is very poor, and the mixing is poor. Unable to smoothly unload during tablet production, it is also impossible to compress uniform tablets

[0008] On the other hand, the sucrose products currently available for direct compression, such as compressible sucrose and sucrose spherical particles, all contain at least 2% of non-sucrose components, such as starch, dextrin, etc., because these components cannot be dissolved in water , and the quality requirement of the effervescent tablet preparation is to dissolve into a clear liquid in water, so the above-mentioned directly compressed sucrose products cannot be used in the prescription of effervescent tablets

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