Eureka AIR delivers breakthrough ideas for toughest innovation challenges, trusted by R&D personnel around the world.

Medicinal composition and application thereof

A composition and drug technology, applied in the field of medicine, can solve problems such as complex efficacy

Active Publication Date: 2018-11-16
JILIN UNIV +1
View PDF2 Cites 3 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It can participate in multiple metabolic pathways, so its efficacy is also complex

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Medicinal composition and application thereof
  • Medicinal composition and application thereof
  • Medicinal composition and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] The preparation of embodiment 1 composition of the present invention

[0032] Each component was weighed according to the weight percentage in Table 1 below, and mixed uniformly to obtain compositions 1, 2 and 3, respectively.

[0033] Composition of Table 1 Compositions 1 to 3

[0034]

[0035] Among them, the preparation method of the total ginseng saponins extract is as follows: take red ginseng as raw material, add 75% ethanol solution for reflux extraction after crushing, the mass volume ratio of red ginseng to ethanol is 1:20g / mL, combine the extracts, concentrate ; The concentrated solution is purified by D101 macroporous resin to obtain total ginsenoside extract.

[0036] The composition of the total ginseng saponins extract obtained is analyzed, and the results are as follows in Table 2:

[0037] The composition of table 2 ginseng total saponins extract

[0038]

Embodiment 2

[0039] The safety evaluation of embodiment 2 compositions of the present invention

[0040] The research of the nonclinical safety evaluation of composition of the present invention is as follows:

[0041] 1. Oral acute toxicity test in mice

[0042] Under the conditions of maximum administration concentration and maximum administration capacity, mice were orally administered compositions 1 to 3 of the present invention, observed continuously for 14 days, and then the maximum tolerated doses of compositions 1 to 3 of the present invention were all 10 mg. / kg.

[0043] 2. Beagle dog oral acute toxicity test

[0044] Under the conditions of maximum dosage concentration and maximum dosage volume, Beagle dogs were orally administered compositions 1-3 of the present invention, and then the maximum tolerated dose of the composition of the present invention was all 10 mg / kg.

[0045] 3. Long-term toxicity of intragastric administration in rats

[0046] Compositions 1 to 3 of the ...

Embodiment 3

[0053] Embodiment 3 Pharmacodynamics

[0054] Ginsenoside monomer alleviates the development of oral ulcers in Hamster mice

[0055] Materials: Hamster mouse, 5'fluorouracil (Sigma), ginsenoside Rk1, ginsenoside Rg5, ginsenoside C-K, ginsenoside Rg3, ginsenoside Rh4, composition 1-3 obtained in Example 1, total ginsenoside extract . 5'fluorouracil was prepared with physiological saline to prepare a solution with a final concentration of 10 mg / mL, and the five kinds of saponin monomers, ginseng total saponin extracts, and compositions 1-3 were respectively prepared with physiological saline with a final concentration of 5 mg / mL.

[0056] Grouping of mice: Divide the mice into 10 groups, 10 in each group, half male and half male, respectively: ginsenoside Rk1 group, ginsenoside Rg5 group, ginsenoside C-K group, ginsenoside Rg3 group, ginsenoside Rh4 group, combination Group 1, group 2, group 3, group ginsenosides extract, and control group.

[0057] Methods: Seven-week-old Ha...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Maximum tolerated doseaaaaaaaaaa
Login to View More

Abstract

The invention relates to a medicinal composition which is prepared from ginsenoside Rk1, ginsenoside Rg5, ginsenoside Rg3, ginsenoside Rh4, ginsenoside C-K and extract of total ginsenoside. The medicinal composition can further comprise a pharmaceutically acceptable carrier. The invention further relates to application of the medicinal composition to preparation of a drug for treating and / or preventing the oral ulcer. The medicinal composition is obvious in medical effect of treating the oral ulcer, has no side effects and enables the disease not to relapse.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a pharmaceutical composition. The present invention also relates to the use of the pharmaceutical composition in the preparation of medicines for treating and / or preventing oral ulcers. Background technique [0002] Oral ulcer, commonly known as "oral sore", is a common ulcerative injury disease that occurs in the oral mucosa. It is more common in the inner lip, tongue, tongue belly, buccal mucosa, vestibular groove, soft palate and other parts. The mucosa in these parts lacks stratum corneum. or poor keratosis. Tongue ulcers refer to oral ulcers that occur on the tongue and the abdomen of the tongue. When oral ulcers attack, the pain is severe, and the local burning pain is obvious. In severe cases, it will also affect eating and speaking, causing great inconvenience to daily life; Symptoms such as swollen lymph nodes. [0003] The occurrence of oral ulcers is the result of a combina...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K36/258A61P1/02A61P29/00A61P37/02A61P35/00A61K31/704
CPCA61K31/704A61K36/258A61P1/02A61P29/00A61P35/00A61P37/02A61K2300/00
Inventor 金英花王宇石李旭明李杨李赫
Owner JILIN UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com