Scutellaria baicalensis root extract as well as preparation method, application thereof and health care wine

A technology of scutellaria baicalensis extract and health wine, which is applied in the field of extraction of plant components, can solve problems such as difficulty in obtaining scutellaria baicalensis extract, affecting macroporous resin adsorption, loss of baicalin, etc., and achieves short cycle, low production cost, and low baicalin content. high effect

Inactive Publication Date: 2018-11-23
劲牌持正堂药业有限公司
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  • Application Information

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Problems solved by technology

However, the water extraction of Scutellaria baicalensis contains more impurities, and it is difficult to obtain a higher content of Scutellaria baicalensis extract through macroporous resin separation; while the ethanol extract is concentrated to recover ethanol, or prepared into crude baicalin and then dissolved in water, because baicalin is insoluble in water. , will precipitate to form a precipitate, which will block the resin and affect the adsorption of the macroporous resin; if the precipitate is removed by filtration, a large amount of baicalin will be lost, thus limiting the application of the macroporous resin method to the preparation of Scutellaria baicalensis extract

Method used

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  • Scutellaria baicalensis root extract as well as preparation method, application thereof and health care wine

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preparation example Construction

[0029] see figure 1 As shown, the embodiment of the present invention provides a preparation method of Scutellaria baicalensis extract, which is to directly dilute the ethanol extract of Scutellaria baicalensis with water to an alcohol concentration of 10%-20%, and then apply macroporous resin for adsorption and separation and purification, thereby obtaining The extract of high-content baicalin specifically comprises the following steps:

[0030] (1) Dilution of the extract: take the ethanol extract of Scutellaria baicalensis, add water to dilute to an alcohol concentration of 10%-20%, and stir evenly to obtain a diluted extract.

[0031] In the present embodiment, the preparation method of Scutellaria baicalensis ethanol extract is:

[0032] Scutellaria baicalensis medicinal material and food-grade ethanol solution with a volume fraction of 50%-75%, the dosage ratio of scutellaria baicalensis medicinal material and ethanol solution is 1kg: 4-8L, heating and refluxing extract...

Embodiment 1

[0046] This embodiment provides a Scutellaria baicalensis extract, which is extracted by the following preparation method:

[0047] (1) Dilution of the extract: take 120L of Scutellaria baicalensis 50% ethanol extract (Scutellaria baicalensis medical material 10Kg), add 480L of pure water to dilute to an ethanol concentration of 10%, stir evenly to obtain a diluted extract.

[0048] (2) Resin adsorption: apply the diluted extract to LS-305 macroporous resin at a flow rate of 5BV / h, and then let it stand for 2 hours for adsorption after the sample is loaded.

[0049] (3) Resin elution: After the adsorption is completed, first add 8 times the amount of pure water for elution, then add 6 times the amount of 50% ethanol for elution, the elution rate is 3BV / h, and the eluent is obtained.

[0050] (4) Concentration and drying: the eluate was concentrated and dried to obtain 1031 g of Scutellaria baicalensis extract. After testing, the content of baicalin was 91.62%, and the yield w...

Embodiment 2

[0053] This embodiment provides a Scutellaria baicalensis extract, which is extracted by the following preparation method:

[0054] (1) Dilution of extract: take 120L of Scutellaria baicalensis 60% ethanol extract (Scutellaria baicalensis medicinal material 10Kg), add 360L of purified water to dilute to ethanol concentration of 15%, stir well to obtain diluted extract.

[0055] (2) Resin adsorption: apply the diluted extract to LS-306 macroporous resin at a flow rate of 7BV / h, and let it stand for adsorption for 1 hour after the sample loading is completed.

[0056] (3) Resin elution: After the adsorption is completed, first add 10 times the amount of pure water for elution, then add 5 times the amount of 60% ethanol for elution, the elution rate is 4BV / h, and the eluate is obtained.

[0057] (4) Concentration and drying: the eluate was concentrated and dried to obtain 1029 g of Scutellaria baicalensis extract. After testing, the content of baicalin was 91.87%, and the yield ...

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Abstract

The invention relates to a scutellaria baicalensis root extract as well as a preparation method, application thereof and health care wine, and relates to the technical field of extraction of plant components. The preparation method for the scutellaria baicalensis root extract comprises the following steps that a scutellaria baicalensis root ethanol extracting solution is taken and is diluted by adding water until the alcohol concentration is 10-20%, and uniform stirring is carried out so as to obtain a diluted extracting solution; macroporous resin is fed into the diluted extracting solution,and then standing and adsorbing are carried out for 0.3-2 hours after the sample feeding is finished; pure water is added for elution, and then an ethanol solution is added for elution so as to obtaineluant; and the eluent is concentrated and dried so as to obtain the scutellaria baicalensis root extract. The preparation method has the advantages of being environmentally friendly, simple in process, low in production cost, high in efficiency, short in period, easy to popularize and high in yield of baicalin; the content of the baicalin in the prepared scutellaria baicalensis root extract is high; the application of the scutellaria baicalensis root extract is used for preparing the health care wine; and the health-care wine contains a lot of baicalin.

Description

technical field [0001] The invention relates to the technical field of extraction of plant components, and in particular to a scutellaria baicalensis extract, its preparation method, application and health wine. Background technique [0002] Scutellaria baicalensis is the dry root of Scutellaria baicale FisiS Georgi, which has the functions of clearing away heat and dampness, purging fire and detoxifying, stopping bleeding and preventing miscarriage. Diarrhea and hot stranguria, damp-heat jaundice, restless fetal movement, carbuncle sore and other symptoms. The flavonoid compound baicalin (baicalin) is the main component of Scutellaria baicalensis. Studies have shown that baicalin has antibacterial, diuretic, anti-inflammatory, anti-allergic and antispasmodic effects, and has strong physiological effects such as anti-cancer response. At present, the Scutellaria baicalensis traditional Chinese medicine preparations collected by the Pharmacopoeia include Shuanghuanglian Oral ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/539C12G3/04A61P11/00A61P11/14A61P11/04A61P31/04A61P35/00A61K125/00
CPCA61K36/539A61K2236/333A61K2236/55A61P11/00A61P11/04A61P11/14A61P31/04A61P35/00C12G3/04
Inventor 徐浪陈志元袁咏红闪媛媛胡力飞
Owner 劲牌持正堂药业有限公司
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