A kind of flexible nerve electrode and the implantation method of flexible nerve electrode

Abstract

The invention discloses a flexible nerve electrode and an implantation method of the flexible nerve electrode. The flexible neural electrode includes a flexible substrate, a flexible insulating layer, and a conductive layer and a magnetic material layer between the flexible substrate and the flexible insulating layer; wherein the conductive layer includes at least one conductive wire, and the conductive wire includes interconnecting wires and respectively The recording sites and welding points located at both ends of the interconnection wire; the magnetic material layer includes a plurality of magnetic material parts, and the magnetic material part corresponds to the first part of the interconnection wire; at least one through hole is formed on the flexible insulating layer, and the through hole is connected to the first part of the interconnection wire. The recording sites are in one-to-one correspondence, and the through holes penetrate the flexible insulating layer to expose the corresponding recording sites. In the technical solution provided by the embodiments of the present invention, the flexible nerve electrode is magnetic and can be implanted into the cerebral cortex under the traction of the magnetic field force, so that the implantation of the flexible nerve electrode will not cause major acute damage to the brain tissue.

Description

technical field [0001] The embodiments of the present invention relate to the field of nerve electrodes, in particular to a flexible nerve electrode and a method for implanting the flexible nerve electrode. Background technique [0002] Nerve electrodes are a hot issue in neuroscience research. They are bridges connecting neurons with external electronic devices. Through nerve electrodes, we can measure the electrophysiological signals of the cerebral cortex, including local field potentials and action potentials. This is important for brain science. It is of great significance for the development of brain diseases and the diagnosis of brain diseases, such as epilepsy, Parkinson's and Alzheimer's diseases. A nerve electrode with excellent performance needs to meet the following two conditions: first, the implantation damage is small, and the rejection reaction of the brain tissue to the electrode is reduced; second, it can have a high temporal and spatial resolution for the ...

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Problems solved by technology

[0003] At present, silicon-based rigid nerve electrodes are the most widely used. Silicon-based nerve electrodes have high spatial-temporal resolution and can record the action potential of a single neuron. However, the mechanical properties of silicon-based nerve electrodes have a large Differences, it is easy to produce micro-movement in the brain tissue, causing a large immune response, and a large number of glial cells will be generated around the electrode, causing the electrode to fail

[0004] In response to the above problems, people have developed flexible nerve electrodes, whose mechanical properties are more compatible with the cerebral cortex, which greatly reduces the tissue immune response. However, the current flexible nerve electrodes generally need to be solidified by curing agents or implanted into the cerebral cortex with the aid of rigid objects. Acute damage to brain tissue

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