Diene open-loop process control system and application system thereof

A process control and metering tank technology, applied in the direction of steroids, organic chemistry, etc., can solve the problems of unstable side reactions and low diene yields, and achieve the effects of safe reactions, complete reactions, and reduced human errors

Active Publication Date: 2018-11-23
湖北民生生物医药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The invention provides a diene ring-opening process control system, which solves the problem in the prior art that the side reaction degree of the ring-opening reaction is unstable due to insufficient control of temperature and pressure, which ultimately leads to a low yield of diene

Method used

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  • Diene open-loop process control system and application system thereof
  • Diene open-loop process control system and application system thereof
  • Diene open-loop process control system and application system thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0056] Such as Figure 1~4 , the present embodiment proposes a diene ring-opening process control system, including a first raw material tank (not shown) and a second raw material tank (not shown), the first raw material tank is stored with acid anhydride, and the second raw material tank stored in glacial acetic acid,

[0057] It also includes two open-loop tanks 1, and each open-loop tank 1 is provided with a first connecting pipe 2, a second connecting pipe 3, a third connecting pipe 4 and a fourth connecting pipe 5, wherein the two first connecting pipes 2 are respectively connected with meters 6, The two second connecting pipes 3 are jointly connected to a buffer tank 7, the two third connecting pipes 4 are connected to a metering tank 8 after converging, and the two fourth connecting pipes are connected to an oxidation tank 9 after converging, and the oxidation tank 9 is used for oxidation and hydrolysis reactions ;

[0058] The metering tank 8 is provided with the fif...

Embodiment 2

[0089] The present embodiment except the following content, all the other parts are identical with embodiment 1; The difference is:

[0090] A method for using a diene ring-opening process control system, comprising the following steps:

[0091] S1 Add diosgenin to the two open-loop tanks 1, adjust the pressure of the metering tank 8 to -0.06Mpa, connect the metering tank 8 and the first raw material tank, and disconnect the metering tank 8 and the first raw material tank when the liquid level of the metering tank 8 shows 80%. Raw material tank;

[0092] S2 adjust the pressure of any open-loop tank 1 to -0.08Mpa, connect the open-loop tank 1 and the metering tank 8, when the liquid level of the metering tank 8 shows 2%, disconnect the open-loop tank 1 and the metering tank 8;

[0093] S3 adjusts the pressure of the metering tank 8 to -0.06Mpa, connects the metering tank 8 and the second raw material tank, and when the liquid level of the metering tank 8 shows 30%, disconnects...

Embodiment 3

[0102] The present embodiment except the following content, all the other parts are identical with embodiment 1; The difference is:

[0103] A method for using a diene ring-opening process control system, comprising the following steps:

[0104] Add diosgenin into two open-loop tanks 1 of S1, adjust the pressure of the metering tank 8 to -0.05Mpa, connect the metering tank 8 and the first raw material tank, and when the liquid level of the metering tank 8 shows 85%, disconnect the metering tank 8 and the first raw material tank. Raw material tank;

[0105] S2 adjusts the pressure of any open-loop tank 1 to -0.07Mpa, connects the open-loop tank 1 and the metering tank 8, and disconnects the open-loop tank 1 and the metering tank 8 when the liquid level of the metering tank 8 shows 5%;

[0106] S3 adjusts the pressure of the metering tank 8 to -0.05Mpa, connects the metering tank 8 and the second raw material tank, and when the liquid level of the metering tank 8 shows 35%, dis...

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PUM

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Abstract

The invention provides a diene open-loop process control system and an application method thereof. The diene open-loop process control system comprises a first raw material tank, a second raw materialtank, two open-loop tanks, two buffering tanks, a measuring tank and an oxidizing tank; and also comprises a valve assembly for controlling the connection and disconnection of the two raw material tanks, the two open-loop tanks, the two buffering tanks, the measuring tank and the oxidizing tank; and also comprises heaters arranged in each open-loop tank and used for heating the open-loop tank, atemperature sensor for detecting the temperature and a pressure sensor for detecting the pressure, and the temperature sensor and the pressure sensor are respectively electrically connected with a metering gauge. The diene open-loop process control system has the beneficial effects that the open-loop reaction temperature and pressure can be conveniently controlled, and by designing the pressure inthe measuring tank and the open-loop tank, raw materials can be conveniently loaded; by adding the measuring tank, the amount of each reaction raw material can be better controlled, and by adding thebuffering tanks, the reverse filling of reactants in the open-loop tank can be prevented; and by controlling the pressure and temperature in the open-loop reaction process, the diene yield is effectively improved.

Description

technical field [0001] The invention relates to the field of chemical equipment, in particular to a diene ring-opening process control system and a use method thereof. Background technique [0002] Pregnancy dienolone acetate (diene for short) is an important intermediate in the synthesis of steroid hormone drugs, and about 70% of steroid hormone drugs use dienes as raw materials. At present, the production process of domestic diene uses diosgenin as raw material, and it is prepared through three steps of ring opening, oxidation and hydrolysis. The specific process route is as follows: [0003] [0004] Among them, the first step reaction is a ring-opening reaction. After adding diosgenin, solid mother liquor, acetic anhydride and acetic acid into the ring-opening tank, the temperature starts to rise. When the internal temperature reaches about 60°C, turn on the vacuum and pump for 5 minutes. When the pressure reaches above -0.08MPa, close the vacuum valve. When the int...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07J13/00
CPCC07J13/005
Inventor 邓海锋陈孝华
Owner 湖北民生生物医药有限公司
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