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Extraction method of guava phyllospheric microganism genome DNA (Deoxyribonucleic Acid)

A guava leaf and extraction method technology, applied in the field of bioengineering, can solve the problems of backward plant phyllosphere microorganisms and little understanding of the characteristics of non-pathogenic phyllosphere microorganisms, and achieve high extraction rate, broad market prospects, and simple operation steps Effect

Active Publication Date: 2018-11-23
THE SECOND XIANGYA HOSPITAL OF CENT SOUTH UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, research on plant phyllosphere microbes lags far behind plant rhizosphere microbes, and little is known about the characteristics of uncultured microbes and non-pathogenic phyllosphere microbes

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] A method for extracting guava phyllosphere microbial genome DNA, comprising the following steps:

[0033] (1) Add 2 g of guava leaves to 4 mL of phosphate buffer solution, add 0.3 g of quartz sand and 0.2 g of 1mm glass beads, shake on an adjustable vortex mixer for 20 min, and then perform ultrasonic (20 min, 300 W) treatment after high-intensity vortex shaking, and centrifuge Obtain the mixed liquor containing phyllosphere microorganisms after removing guava leaves;

[0034](2) Add 150uL TENP solution to the mixture containing phyllosphere microorganisms, -20°C, 18min, 45°C for 5min, freeze-thaw 3 times, then add 5uL 100mg / mL lysozyme and proteinase K, at 37°C Water bath for 40 minutes, invert the centrifuge tube up and down 4 times, then add 0.5mL SDS buffer, bath in 68°C water for 40 minutes, invert the centrifuge tube up and down 4 times, centrifuge at 15°C, 1000rpm for 10min to obtain precipitate a and supernatant a; a replace the mixed solution containing phyllo...

Embodiment 2

[0040] A method for extracting guava phyllosphere microbial genome DNA, comprising the following steps:

[0041] (1) is identical with embodiment 1 step (1);

[0042] (2) Add 150uL TENP solution to the mixture containing phyllosphere microorganisms, -20°C, 18min, 45°C for 5min, freeze-thaw 3 times, then add 5uL 100mg / mL lysozyme and proteinase K, at 37°C Water bath for 40 minutes, invert the centrifuge tube up and down 4 times, then add 0.5mL SDS buffer, bath in 68°C water for 40 minutes, invert the centrifuge tube up and down 4 times, centrifuge at 15°C, 1000rpm for 10min to obtain precipitate a and supernatant a; a replace the mixed solution containing phyllosphere microorganisms and repeat the above steps twice; wherein, the composition of the TENP solution includes: 50mM Tris, 20mM EDTA, 100mM NaCl, 0.01g / mLPVP, the pH of the TENP solution is 10; the composition of the SDS buffer Including: 100mmoL / LTris, 100mmoL / L EDTA-2Na, 200mmoL / L NaCl, volume fraction of 2% PVP, volu...

Embodiment 3

[0048] A method for extracting guava phyllosphere microbial genome DNA, comprising the following steps:

[0049] (1) is identical with embodiment 1 step (1);

[0050] (2) Add 150uL TENP solution to the mixture containing phyllosphere microorganisms, freeze and thaw repeatedly 4 times at -20°C for 18min and 45°C for 5min, then add 5uL of 100mg / mL lysozyme and proteinase K at 37°C Water bath for 40 minutes, invert the centrifuge tube up and down 4 times, then add 0.5mL SDS buffer, bath in 68°C water for 40 minutes, invert the centrifuge tube up and down 4 times, centrifuge at 15°C, 1000rpm for 10min to obtain precipitate a and supernatant a; a replace the mixed solution containing phyllosphere microorganisms and repeat the above steps once; wherein, the components of the TENP solution include: 50mM Tris, 20mM EDTA, 100mM NaCl, 0.01g / mLPVP, the pH of the TENP solution is 10; the components of the SDS buffer include : 100mmoL / LTris, 100mmoL / L EDTA-2Na, 200mmoL / L NaCl, the volume ...

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Abstract

The invention relates to an extraction method of guava phyllospheric microganism genome DNA (Deoxyribonucleic Acid). The method comprises the following steps of (1) adding guava leaves stored in liquid nitrogen into a phosphate buffer solution, then adding sterile quartz sand and glass beads, carrying out ultrasonic treatment after vibration, and centrifuging to obtain a mixed solution containinga phyllospheric microganism; (2) adding a TENP solution into the mixed solution containing the phyllospheric microganis, after carrying out multigelation treatment, adding lysozyme and proteinase K, carrying out water bath, then adding an SDS buffer solution, carrying out water bath, and centrifuging to obtain a precipitate a and a supernatant liquor a; (3) adding chloroform and isoamylol into thesupernatant liquor a, and centrifuging to obtain a precipitate b and a supernatant liquor b; (4) adding a PEG8000 precipitator into the supernatant liquor b, and after cryopreserving, centrifuging toobtain a precipitate c and a supernatant liquor c; (5) washing the precipitate c through ethyl alcohol, and after centrifugally freeze drying, obtaining the guava phyllospheric microganism genome DNA. The method provided by the invention is simple, high in extraction rate, and wide in market application prospect.

Description

technical field [0001] The invention belongs to the technical field of bioengineering, in particular to a method for extracting genome DNA of plant phyllosphere microorganisms. Background technique [0002] As an independent microenvironment, the aboveground parts of plants (including leaves, stems, flowers, fruits, etc.) usually inhabit a large number of various types of microorganisms on the surface and inside. The aboveground part of the plant is called the phyllosphere, and the microbial groups that live on the phyllosphere and can colonize and proliferate are called epiphytes. For a long time, the research on plant phyllosphere microorganisms has mainly focused on the behavior and control of plant pathogenic microorganisms. Many plant pathogenic bacteria have been purely cultured, and many obligate parasitic pathogens have been preserved on living plants. However, the research on plant phyllosphere microbes is far behind that of plant rhizosphere microbes, and little i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12N15/10
CPCC12N15/1006C12Q2521/537
Inventor 申丽谢志国曾伟民周智广吴学玲李交昆余润兰刘元东胡芳王俊俊邱冠周
Owner THE SECOND XIANGYA HOSPITAL OF CENT SOUTH UNIV