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Water-soluble fullerene composition for external use

A kind of technology of fullerene and composition, applied in the field of daily chemical

Active Publication Date: 2021-01-29
苏州仁生泽发生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The hydrophobic nature of fullerene itself directly affects its biological activity. In order to better promote absorption, fullerene is made into a solution type that is easy for the skin to absorb quickly and is in a molecular state. Fullerene is compounded with a skin-friendly type components have not been studied

Method used

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  • Water-soluble fullerene composition for external use
  • Water-soluble fullerene composition for external use
  • Water-soluble fullerene composition for external use

Examples

Experimental program
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preparation example Construction

[0043] In one embodiment, the present invention provides a method for preparing a fullerene composition or dispersion system, which is characterized in that it includes the following steps: (1) take fullerene powder and carbohydrate additives, and mix them uniformly; (2) Ball milling and compounding; (3) Dissolving: Fully dissolve the prepared fullerene composite material with deionized water; (4) Centrifugation: Centrifuge the dissolved solution at a high speed of 8500r / min for 5min to remove Undissolved large particles in the solution; (5) Filtration: Use a G4 sand core funnel to filter out the fine precipitates in the solution; (6) Concentration: Use vacuum rotary evaporation or microfiltration membrane to remove the solution from the obtained filtrate (7) drying: use freeze drying or spray drying to remove water to obtain water-soluble fullerene powder.

[0044] In one embodiment, the present invention provides a fullerene composition characterized in that, in addition to ...

Embodiment 1

[0066] Example 1: Compounding of hydroxyethyl cellulose, sodium hyaluronate and glucose with fullerene:

[0067] 1), using hydroxyethyl cellulose to carry out ball milling compounding of fullerene

[0068] A. Sampling at different ball milling times and at different time points, weighed 0.1 g of hydroxyethyl cellulose: fullerene composition, slowly added to 80 ml of deionized water, dissolved and stirred for 30 min.

[0069]

[0070] Summary: In the case of the same feed ratio, with the increase of ball milling time, the UV absorbance A value gradually increases, indicating that the fullerene content in the water-soluble composition gradually increases, and the recombination rate gradually increases, but when the ball mill reaches 12h, the fullerene The content is lower than that of ball milling for 10 hours, indicating that when the ball milling time is too long, the solubility of the water-soluble composition will decrease, and the content of fullerene in the correspondin...

Embodiment 3

[0099] Embodiment 3, dynamic light scattering-detecting the particle size of the material in the aqueous solution

[0100] The raw materials in the table were prepared into 0.1% aqueous solution, and the particle size was tested by dynamic light scattering.

[0101] raw material name DLS average particle size nm Hydroxyethyl Cellulose-Fullerene 740 Sodium Hyaluronate-Fullerene 730 Glucose-Fullerene 670 Hydroxyethyl Cellulose: Sodium Hyaluronate: Glucose-Fullerene 738

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Abstract

The invention discloses a water-soluble fullerene external composition and its preparation method and application. The water-soluble fullerene external composition contains a water-soluble auxiliary agent and fullerene dissolved or dispersed in the water-soluble auxiliary agent. Things have a beauty effect.

Description

technical field [0001] The invention relates to the field of daily chemicals, in particular to an external composition with cosmetic effect. Background technique [0002] In 1985, scientists Kroto, Smalley, Curl and others discovered C60 fullerene when studying carbon elements in deep space. In 1996, they won the Nobel Prize in Chemistry for this. Fullerene, diamond and graphite are allotropes of carbon. C60 is a spherical molecule composed of 60 carbon atoms, consisting of 12 pentagons and 20 hexagons, each carbon atom and adjacent three carbon atoms pass through SP 2 Hybridized into bonds, it is called CITE because it looks like a football. A series of molecules with a cage-like carbon atom cluster structure are collectively referred to as molecules and are collectively referred to as caged Note><Cite><Auene derivatives and heterocyclic fullerenes. Common C60, C70, C76, C84 and other types. [0003] The large π-bonded conjugated system composed of multiple ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/19A61K8/60A61K8/73A61K8/04A61Q19/00A61Q19/02A61Q7/00A61K47/04A61K9/10A61P17/00A61P17/14A61P17/10
CPCA61K47/02A61P17/00A61P17/10A61P17/14A61Q7/00A61Q19/00A61Q19/02A61K8/04A61K8/19A61K8/60A61K8/731A61K8/735A61K9/0014A61K9/10A61K47/38A61K47/26A61K8/044A61K2800/10A61K31/015
Inventor 李慧王春儒许哲
Owner 苏州仁生泽发生物科技有限公司