Electrolyte injection for children

Abstract

The invention provides an electrolyte injection for children and a preparation method thereof, belonging to the technical field of medicine. The electrolyte injection mainly comprises sodium chloridewith a concentration of 5.5-6.5 g / L, potassium chloride with a concentration of 0.1-0.5 g / L, calcium chloride dihydrate with a concentration of 0.1-0.3 g / L, magnesium chloride hexahydrate with a concentration of 0.1-0.4 g / L, sodium acetate trihydrate with a concentration of 2.5-4.5 g / L, dextrose monohydrate with a concentration of 11-27.5 g / L, water for injection and a pH value regulator, whereinthe pH value regulator is hydrochloric acid or sodium hydroxide and has a pH value of about 5.0 to 6.0 and osmotic pressure of about 350-400 mOsm / L. The preparation method comprises the following steps: (1) preparation of a dilute solution: adding 40%-80% by volume of fresh injection water with a temperature of 40-75 DEG C into a dilute-solution preparation tank, weighing each raw material of desired prescription dosage, staring stirring, slowly adding the raw materials into the dilute-solution preparation tank, carrying out stirring, then adding injection water into the dilute-solution preparation tank to a desired prescription dosage, continuing stirring for 30 minutes, starting a transfer pump after complete dissolving, allowing medicinal liquid to pass through a 5-[mu]m filter core anda 0.45-[mu]m filter core separately and to flow back via a return pipeline, cyclically repeating the above filtering and back-flowing for 10 to 30 min, and then sampling a semi-finished product for alaboratory test; (2) filling: carrying out filtering with a 5-[mu]m microporous filter core, a 0.45-[mu]m microporous filter core and a 0.2-[mu]m microporous filter core, and then carrying out filling; and (3) sterilization. The electrolyte injection of the invention can maintain the balance of a main electrolyte in intracellular and extracellular fluids, and avoid insufficient blood sugar or high blood sugar.

Description

technical field [0001] The invention provides an electrolyte injection for children and a preparation method thereof, and relates to the technical field of medicine, in particular to a formula and a preparation method of an electrolyte solution containing sugar and electrolytes for children's perioperative period. Background technique [0002] In a paper published in Eur J Anaesthesiol (European Journal of Anesthesiology) in 2011, it was pointed out that the optimal glucose content of the isotonic infusion used during surgery in children is 1%-2.5%, and children have higher brain size compared to adults Compared with cranial crest, and lower Na-K-ATPase activity, hyponatremia encephalopathy is more likely to occur, and the traditional hypotonic solution containing 5% glucose can easily cause hyponatremia, which can damage the brain of children. In addition, infants are at greater risk of perioperative lipolysis and hypoglycemia because of their higher metabolic rate, and per...

AI Technical Summary

Problems solved by technology

[0004] The invention provides an electrolyte injection for children and a preparation method thereof, which fills the gap in the electrolyte injection for children's surgery on the market, and solves the problem of hyperglycemia caused by giving high-concentration glucose during the perioperative period in the prior art, which is not suitable for children's forehead. Injection and other technical issues

Images