Electrolyte injection for children

A technology for electrolyte injection and injection, which is applied to medical preparations with non-active ingredients, medical preparations containing active ingredients, metabolic diseases, etc. Effects of hypoglycemia or hyperglycemia, metabolic acidosis avoidance

Inactive Publication Date: 2018-11-30
HUAREN PHARMACEUTICAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The invention provides an electrolyte injection for children and a preparation method thereof, which fills the gap in the electrolyte injection for children's surgery on the market, and solves the

Method used

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  • Electrolyte injection for children
  • Electrolyte injection for children
  • Electrolyte injection for children

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] The preparation formula of electrolyte supplement injection for children is as follows:

[0021]

[0022] The preparation method is as follows

[0023] Dilute preparation: add 40-75℃, 40%-80% volume fresh water for injection into the dilute preparation tank, weigh each raw material of the prescription amount, start stirring, slowly put into the dilute preparation tank, and stir for 5-30 minutes , and then add water for injection to the prescription amount into the dilute preparation tank, continue to stir for 30 minutes, turn on the infusion pump after the dissolution is complete, and let the liquid medicine flow back through the 5um, 0.45um filter element and the return line respectively, and circulate for 10 to 30 minutes. Sampling and testing semi-finished products, after passing the test, start filling.

[0024] Filling: After filtering through 5um, 0.45um, 0.2um, microporous filter elements, adjust the filling volume to pass the filling.

[0025] Sterilization...

Embodiment 2

[0027] The preparation formula of electrolyte supplement injection for children is as follows:

[0028]

[0029] The preparation method is as follows

[0030] Dilute preparation: add 40-75℃, 40%-80% volume fresh water for injection into the dilute preparation tank, weigh each raw material of the prescription amount, start stirring, slowly put into the dilute preparation tank, and stir for 5-30 minutes , and then add water for injection to the prescription amount into the dilute preparation tank, continue to stir for 30 minutes, turn on the infusion pump after the dissolution is complete, and let the liquid medicine flow back through the 5um, 0.45um filter element and the return line respectively, and circulate for 10 to 30 minutes. Sampling and testing semi-finished products. After passing the test, start filling.

[0031] Filling: After filtering through 5um, 0.45um, 0.2um, microporous filter elements, adjust the filling volume to pass the filling.

[0032] Sterilizatio...

Embodiment 3

[0034] The preparation formula of electrolyte supplement injection for children is as follows:

[0035]

[0036] The preparation method is as follows

[0037] Dilute preparation: add 40-75℃, 40%-80% volume fresh water for injection into the dilute preparation tank, weigh each raw material of the prescription amount, start stirring, slowly put into the dilute preparation tank, and stir for 5-30 minutes , and then add water for injection to the prescription amount into the dilute preparation tank, continue to stir for 30 minutes, turn on the infusion pump after the dissolution is complete, and let the liquid medicine flow back through the 5um, 0.45um filter element and the return line respectively, and circulate for 10 to 30 minutes. Sampling and testing semi-finished products. After passing the test, start filling.

[0038] Filling: After filtering through 5um, 0.45um, 0.2um, microporous filter elements, adjust the filling volume to pass the filling.

[0039] Sterilizatio...

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Abstract

The invention provides an electrolyte injection for children and a preparation method thereof, belonging to the technical field of medicine. The electrolyte injection mainly comprises sodium chloridewith a concentration of 5.5-6.5 g/L, potassium chloride with a concentration of 0.1-0.5 g/L, calcium chloride dihydrate with a concentration of 0.1-0.3 g/L, magnesium chloride hexahydrate with a concentration of 0.1-0.4 g/L, sodium acetate trihydrate with a concentration of 2.5-4.5 g/L, dextrose monohydrate with a concentration of 11-27.5 g/L, water for injection and a pH value regulator, whereinthe pH value regulator is hydrochloric acid or sodium hydroxide and has a pH value of about 5.0 to 6.0 and osmotic pressure of about 350-400 mOsm/L. The preparation method comprises the following steps: (1) preparation of a dilute solution: adding 40%-80% by volume of fresh injection water with a temperature of 40-75 DEG C into a dilute-solution preparation tank, weighing each raw material of desired prescription dosage, staring stirring, slowly adding the raw materials into the dilute-solution preparation tank, carrying out stirring, then adding injection water into the dilute-solution preparation tank to a desired prescription dosage, continuing stirring for 30 minutes, starting a transfer pump after complete dissolving, allowing medicinal liquid to pass through a 5-[mu]m filter core anda 0.45-[mu]m filter core separately and to flow back via a return pipeline, cyclically repeating the above filtering and back-flowing for 10 to 30 min, and then sampling a semi-finished product for alaboratory test; (2) filling: carrying out filtering with a 5-[mu]m microporous filter core, a 0.45-[mu]m microporous filter core and a 0.2-[mu]m microporous filter core, and then carrying out filling; and (3) sterilization. The electrolyte injection of the invention can maintain the balance of a main electrolyte in intracellular and extracellular fluids, and avoid insufficient blood sugar or high blood sugar.

Description

technical field [0001] The invention provides an electrolyte injection for children and a preparation method thereof, and relates to the technical field of medicine, in particular to a formula and a preparation method of an electrolyte solution containing sugar and electrolytes for children's perioperative period. Background technique [0002] In a paper published in Eur J Anaesthesiol (European Journal of Anesthesiology) in 2011, it was pointed out that the optimal glucose content of the isotonic infusion used during surgery in children is 1%-2.5%, and children have higher brain size compared to adults Compared with cranial crest, and lower Na-K-ATPase activity, hyponatremia encephalopathy is more likely to occur, and the traditional hypotonic solution containing 5% glucose can easily cause hyponatremia, which can damage the brain of children. In addition, infants are at greater risk of perioperative lipolysis and hypoglycemia because of their higher metabolic rate, and per...

Claims

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Application Information

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IPC IPC(8): A61K33/14A61K9/08A61K47/02A61K47/26A61P3/12A61K33/06A61K31/19A61K31/7004
CPCA61K9/0019A61K9/08A61K31/19A61K31/7004A61K33/06A61K33/14A61K47/02A61K47/26A61P3/12A61K2300/00
Inventor 陆宇冯新光叶芳
Owner HUAREN PHARMACEUTICAL CO LTD
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