Improved device for preparing polymer drug-loaded particles by supercritical antisolvent method

Abstract

The invention discloses an improved device for preparing polymer drug-loaded particles by a supercritical antisolvent method, wherein the device includes a supercritical fluid supply branch, a solution supply branch, a supercritical fluid impregnation branch, a pressure control system and a granulation system. According to the device, for drugs insoluble in supercritical fluid, a solution containing a polymer and a drug and the supercritical fluid are used for preparing polymer drug-loaded particles in a granulating tank by the supercritical antisolvent method; for drugs soluble in the supercritical fluid, the polymer particles are prepared by an antisolvent method, and the polymer drug-loaded particles are prepared by a supercritical impregnation technology. The device realizes the coupling of a supercritical solution impregnation system and a supercritical anti-solvent system, and enables drugs with various solubility properties in the supercritical fluid to achieve high-efficiency loading in the polymer particles.

Description

technical field [0001] The invention relates to the technical field of preparing polymer drug-carrying particles by supercritical fluid anti-solvent method, in particular to an improved device for preparing polymer drug-carrying particles by supercritical anti-solvent method. Background technique [0002] In the field of food and pharmaceutical preparations, supercritical fluids, especially supercritical carbon dioxide, have great practical advantages due to their lower critical temperature and critical pressure. Corrosion, no residue and other characteristics make it a green alternative to traditional organic solvents, and has received extensive attention. Researchers have developed a variety of formulation technologies based on supercritical fluids. [0003] Supercritical fluid anti-solvent technology (Supercritical Fluid Anti-solvent, SAS) is a commonly used formulation technology, which firstly dissolves the compound or polymer of the desired formulation in a solvent tha...

AI Technical Summary

Problems solved by technology

[0005] In order to overcome the problem that the existing supercritical anti-solvent method for preparing polymer drug-loaded particles cannot achieve efficient encapsulation of substances easily soluble in supercritical fluids, the present invention provides an improved supercritical anti-solvent method for preparing polymer drug-loaded particles. , the device is coupled with supercritical fluid anti-solvent technology and supercritical fluid impregnation technology, and can efficiently load substances with different solubility properties in supercritical fluid into polymer particles. To achieve this purpose, the present invention provides an improved A polymer drug-loaded particle device prepared by a supercritical antisolvent method, including a supercritical fluid supply branch, a solution supply branch, a supercritical fluid impregnation branch, a pressure control system and a granulation system, the supercritical fluid supply branch is The supercritical fluid storage tank, the third valve, the cooling tank, the fourth valve, the second high-pressure delivery pump and the second flow control meter are connected in sequence through pipelines, and the granulation system is a granulation tank connected in sequence through pipelines, the first Eight valves, a solvent recovery tank, an eleventh valve and a third flow control meter, the second flow control meter of the supercritical fluid supply branch is connected with the granulation tank of the granulation system through the sixth valve, and the solution supply The branch is connected in turn by the solution storage tank, the first valve, the first high-pressure delivery pump, the first flow control meter and the second valve, and then connected to the granulation tank through pipelines; Connect the seventh valve, the medicine tank, and the fifth valve to the inlet of the second high-pressure delivery pump; the pressure control system is sequentially connected to the nitrogen storage tank and the twelfth valve and then connected to the second high-pressure delivery pump through pipelines. The drug tank and the granulation tank are connected with a pressure relief valve

Images