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Compound for treating open injuries, and preparation method and application thereof

A complex and open technology, applied in the field of medicine, can solve the problems of low effective concentration, large gradient of disinfectant concentration, and complex ingredients of traditional Chinese medicine, and achieve the effect of safe concentration, no allergic reaction, and extensive bactericidal effect

Pending Publication Date: 2018-12-07
张津育
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since the disinfectant and other components are only physically mixed, it will occur in the early stage of hemostasis, the concentration gradient of the disinfectant is the largest, and the release speed is too fast. After a large amount of disinfectant is released, the concentration will decrease in the later stage
Therefore, there is a risk of excessive absorption of poisoning at the wound site or low effective concentration
The traditional Chinese medicine ingredients in the formula are complex, containing carbohydrates, proteins, lipids and other nutrients, which provide nutrients for microorganisms and are not conducive to maintaining a sterile environment for wounds

Method used

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  • Compound for treating open injuries, and preparation method and application thereof
  • Compound for treating open injuries, and preparation method and application thereof
  • Compound for treating open injuries, and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] 95% medicinal ethanol is added with an appropriate amount of purified water to prepare an ethanol solution with a concentration of 65%-90%. Chlorhexidine is added at normal temperature and stirred until the chlorhexidine is completely dissolved to prepare a chlorhexidine ethanol solution with a concentration of 0.1%-0.5%. Take 300 liters of the above solution and add it to the reaction kettle. Weigh 8-15 kg of sodium carboxymethyl cellulose, and slowly add it to the reaction kettle at room temperature, stirring or ultrasonic vibration to ensure that the addition is completely completed within 30-60 minutes. Since the reaction is a heterogeneous system, sufficient stirring or ultrasonic vibration is required to ensure the completion of the reaction. This reaction is an exothermic reaction, and no heating is required during the reaction. After the reaction was continued for 2-3 hours, 100 liters of ethanol solutions with a concentration of 65%-90% were added in three ti...

Embodiment 2

[0039] 95% medicinal ethanol is added with an appropriate amount of purified water to prepare an ethanol solution with a concentration of 65%-90%. Add 20% polyhexamethylene guanidine at normal temperature, stir until the polyhexamethylene guanidine is completely dissolved, and prepare a polyhexamethylene guanidine ethanol solution with a concentration of 0.1%-0.5%. Take 300 liters of the above solution and add it to the reaction kettle. Weigh 10-16 kg of sodium carboxymethyl cellulose, and slowly add it to the reaction kettle at room temperature, stirring or ultrasonic vibration to ensure complete addition within 30-60 minutes. Since the reaction is a heterogeneous system, sufficient stirring or ultrasonic vibration is required to ensure the completion of the reaction. This reaction is an exothermic reaction, and no heating is required during the reaction. After the reaction was continued for 2-3 hours, 100 liters of ethanol solutions with a concentration of 65%-90% were add...

Embodiment 3

[0041] 95% medicinal ethanol is added with an appropriate amount of purified water to prepare an ethanol solution with a concentration of 65%-90%. Add benzalkonium bromide at normal temperature, stir until the benzalkonium bromide is completely dissolved, and prepare a benzalkonium bromide ethanol solution with a concentration of 0.1%-0.5%. Take 300 liters of the above solution and add it to the reaction kettle. Weigh 12-20 kg of sodium carboxymethyl cellulose, and slowly add it to the reaction kettle at room temperature, stirring or ultrasonic vibration to ensure that it is completely added within 30-60 minutes. Since the reaction is a heterogeneous system, sufficient stirring or ultrasonic vibration is required to ensure the completion of the reaction. This reaction is an exothermic reaction, and no heating is required during the reaction. After the reaction was continued for 1-2 hours, 100 liters of ethanol solutions with a concentration of 65%-90% were added in three tim...

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PUM

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Abstract

The invention belongs to the technical field of medicines, and concretely relates to a compound for treating open injuries, and a preparation method and an application thereof. The compound for treating open injuries is prepared form a guanidine disinfectant and / or a quaternary ammonium salt disinfectant, and water-soluble anionic cellulose and a derivative thereof. The compound for treating openinjuries can minimize the exposure time of wounds and minimize the amount of bacteria and bacterial endotoxins in various emergency situations. The compound for treating open injuries is convenient tostore, carry and use, and has a broad application prospect in the field of focused open injury treatment.

Description

technical field [0001] The invention belongs to the technical field of medicine, and particularly relates to a compound for treating open injury, a preparation method and application thereof, and the compound for treating open injury can be used for treating open injury. Background technique [0002] An open injury, as opposed to a closed injury, as the name suggests, is an injury in which the internal tissues (such as muscles, bones, etc.) of the injured part communicate with the outside world; in short, it is a wound in which blood can flow out, or a muscle or bone leaks out. Such as abrasions, lacerations, cuts, stab wounds, etc. Closed injuries are generally wounds that do not see blood, such as muscle strains. Open wounds are more common in peacetime or wartime. Because wounds are often contaminated, if they are not handled in time or improperly, they are prone to infection, which affects healing and functional recovery. In severe cases, it can cause disability or even...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/155A61K31/785A61K31/14A61K31/717A61L15/28A61L15/46A61P31/04A61P31/10A61P17/02
CPCA61K31/14A61K31/155A61K31/717A61K31/785A61L15/28A61L15/46A61L2300/404A61L2300/232A61L2300/208A61L2300/206C08L1/286A61P17/02A61P31/04A61P31/10A61K2300/00A61K47/38
Inventor 张津育王锋
Owner 张津育