Preparation method for water-soluble natural vitamin E

A natural vitamin, water-soluble technology, applied in the field of preparation of water-soluble natural vitamin E, can solve the problems of inability to prepare high-purity TPGS, large separation loss of separation means, unclean separation of impurities, etc., and achieves easy automatic operation and simplified reaction. Post-processing operations to achieve the effect of automated operations
CN108976407AActive Publication Date: 2018-12-11ZHEJIANG UNIV OF TECH
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
ZHEJIANG UNIV OF TECH
Publication Date
2018-12-11

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Abstract

The invention discloses a preparation method for water-soluble natural vitamin E. the method comprises the steps that chloromethylated polystyrene resin and PEG1000 serve as raw materials, alkali serves as a catalyst, and reaction is carried out in an organic solvent at 45-135 DEG C so as to obtain PEG1000-loaded resin; under the action of the catalyst, 4-dimethylaminopyridine (DMAP) and tetrahydrofuran, water division reflux reaction is carried out on the PEG1000-loaded resin and d-alpha-tocopherol succinate so as to obtain TPGS-loaded resin; and after the TPGS-loaded resin is soaked by usingmethylbenzene, ethanol, palladium carbon and pyridoxal phosphate are added, and under the atmosphere of 0.8-1.5 MPa of hydrogen , stirring is carried out for reaction for 24 hours at the temperatureof 100-110 DEG C so as to obtain d-alpha-tocopherol polyethylene glycol succinate. According to the synthetic method, the yield of TPGS can reach 97.8%, the TPGS monoester content is 98.6%, and the TPGS diester content is 0.
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Description

technical field

[0001] The invention relates to a preparation method of water-soluble natural vitamin E represented by formula VI.

[0002] Background technique

[0003] Water-soluble natural vitamin E, d-α-tocopheryl polyethylene glycol succinate (d-α-TocopherylPolyethylene Glycol Succinate, TPGS), which is composed of d-α-tocopheryl succinate and polyethylene glycol 1000 ( Polymerization degree is 22 to 23) and it is obtained by esterification (VI). It is a white to light brown waxy solid, which is miscible with water and common organic solvents and can exist stably in the air. TPGS contains both the lipophilic group of tocopherol and the hydrophilic group of polyethylene glycol long chain. It is a non-ionic surfactant and an effective tocopherol supplement and absorption enhancer. Various excipients have broad application prospects in the food, pharmaceutical and health care products markets.

[0004] d-α-tocopherol has strong physiological and pharmacological activi...

Claims

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